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Indeterminate breast lesions found in high-risk patients should be evaluated aggressively to exclude malignancy, study finds

Date:
May 3, 2010
Source:
American College of Radiology / American Roentgen Ray Society
Summary:
Short-term follow-up is often used to evaluate indeterminate breast lesions found on breast magnetic resonance imaging. However, researchers have found that indeterminate lesions (found in women with a high risk of breast cancer) should be evaluated sooner to exclude a possible malignancy, according to a new study.

Short-term follow-up is often used to evaluate indeterminate breast lesions found on breast magnetic resonance imaging (MRI). However, researchers have found that indeterminate lesions (found in women with a high risk of breast cancer) should be evaluated sooner to exclude a possible malignancy, according to a study presented at the American Roentgen Ray Society 2010 Annual Meeting in San Diego, CA.

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Breast lesions that cannot be definitively classified as suspicious for malignancy or benign are considered indeterminate. "A short-term follow-up MRI, ultrasound, and/or mammographic investigation is usually recommended for indeterminate lesions found in high-risk women," said Martin Korzeniowski, MD, lead author of the study. "However, that may not be soon enough," said Korzeniowski. High-risk women include those who have breast cancer, a history of breast cancer, or a genetic predisposition.

The study, performed at McMaster University in Hamilton, Canada, included 59 lesions in 55 patients that were identified on breast MRI as indeterminate. "Of those indeterminate lesions, a significant number (22 percent) were proven positive for malignancy on follow-up and subsequent biopsy," he said.

"In our study, the cancer yield was substantial for indeterminate lesions identified on initial contrast-enhanced breast MRI which suggests that those lesions should be evaluated more aggressively to exclude malignancy and increase one's chances for survival," said Korzeniowski.


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The above story is based on materials provided by American College of Radiology / American Roentgen Ray Society. Note: Materials may be edited for content and length.


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American College of Radiology / American Roentgen Ray Society. "Indeterminate breast lesions found in high-risk patients should be evaluated aggressively to exclude malignancy, study finds." ScienceDaily. ScienceDaily, 3 May 2010. <www.sciencedaily.com/releases/2010/05/100503135422.htm>.
American College of Radiology / American Roentgen Ray Society. (2010, May 3). Indeterminate breast lesions found in high-risk patients should be evaluated aggressively to exclude malignancy, study finds. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2010/05/100503135422.htm
American College of Radiology / American Roentgen Ray Society. "Indeterminate breast lesions found in high-risk patients should be evaluated aggressively to exclude malignancy, study finds." ScienceDaily. www.sciencedaily.com/releases/2010/05/100503135422.htm (accessed November 26, 2014).

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