Featured Research

from universities, journals, and other organizations

Definitive diabetes indicator deceptively high in African-American children

Date:
May 4, 2010
Source:
Louisiana State University Health Sciences Center
Summary:
Researchers have found there is a major difference in the hemoglobin A1c response to blood glucose between African-American and Caucasian children with diabetes. African-Americans test significantly higher than Caucasians who have similar average blood glucose levels, misleading their doctors into believing that glucose levels are higher than they really are. If both tests aren't taken into account, doctors could unintentionally provoke increased episodes of life-threatening hypoglycemia in African-American patients.

Researchers at LSU Health Sciences Center New Orleans and Children's Hospital of New Orleans have found that there is a major difference in the hemoglobin A1c (HbA1c) response to blood glucose between African-American and Caucasian children with diabetes. HbA1c is the main test used to monitor diabetes and guide treatment decisions. African-American children test significantly higher than Caucasians who have similar average blood glucose levels. The research may explain why African Americans are at increased risk of diabetes complications.

Related Articles


The study is published in the May 2010 issue of the journal Diabetes Care.

The study has important implications for clinical practice. "The HbA1c can be deceptive in African American children with diabetes, misleading their doctors into believing that glucose levels are higher than they really are, " notes Stuart A. Chalew, MD, Professor of Pediatrics and Head of the Division of Endocrinology in the Department of Pediatrics at LSU Health Sciences Center New Orleans School of Medicine. "If doctors don't take both HbA1c and self-monitored blood sugar levels into account, they are likely to unintentionally provoke increased episodes of life-threatening hypoglycemia in African-American patients."

The research team, which also included James M. Hempe, PhD, Associate Professor of Pediatrics, and Jodi L. Kamps, PhD, Clinical Assistant of Pediatrics at LSU Health Sciences Center New Orleans, followed 276 children at Children's Hospital of New Orleans with type 1 diabetes over a six-year period. The average age of participants was 12.5 years with an average duration of diabetes of nearly 5 years. The researchers obtained HbA1c levels and mean blood glucose levels -- the average of self-monitored blood glucose measurements downloaded from strip-based glucose meters for periods of at least 30 days. By analyzing a hemoglobin glycation index (HGI) which assesses biological variation in A1c after accounting for the effect of mean blood glucose, the team found that there were significant differences in HGI groups by race but not by gender. About 58% of the African-American children were in the high HGI group compared to only about 24% of the Caucasian participants.

"Besides the risk of over-treating with insulin and provoking hypoglycemia, the data also suggest that there is a need for alternate therapies to reduce diabetes complications other than insulin and other glucose lowering agents," concludes Dr. Chalew.

According to the American Diabetes Association, almost 24 million people, or about 8% of the population of the United States, have diabetes, including about one in every 400-600 children and adolescents. It is the seventh leading cause of death and is the leading cause of kidney failure. Diabetes is associated with an increased risk of heart disease, stroke, high blood pressure, blindness, nervous system damage, and non-traumatic lower-limb amputations.


Story Source:

The above story is based on materials provided by Louisiana State University Health Sciences Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. J. L. Kamps, J. M. Hempe, S. A. Chalew. Racial Disparity in A1C Independent of Mean Blood Glucose in Children With Type 1 Diabetes. Diabetes Care, 2010; 33 (5): 1025 DOI: 10.2337/dc09-1440

Cite This Page:

Louisiana State University Health Sciences Center. "Definitive diabetes indicator deceptively high in African-American children." ScienceDaily. ScienceDaily, 4 May 2010. <www.sciencedaily.com/releases/2010/05/100504113119.htm>.
Louisiana State University Health Sciences Center. (2010, May 4). Definitive diabetes indicator deceptively high in African-American children. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2010/05/100504113119.htm
Louisiana State University Health Sciences Center. "Definitive diabetes indicator deceptively high in African-American children." ScienceDaily. www.sciencedaily.com/releases/2010/05/100504113119.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins