Featured Research

from universities, journals, and other organizations

New genes involved in human eye color identified

Date:
May 7, 2010
Source:
Public Library of Science
Summary:
Three new genetic loci have been identified with involvement in subtle and quantitative variation of human eye color. Previous studies on the genetics of human eye color used broadly-categorized trait information such as 'blue', 'green', and 'brown'. However, variation in eye color exists in a continuous grading from the lightest blue to the darkest brown.

Human eye color cannot be categorized as simply 'blue', 'green', and 'brown', new research shows. Instead, variation in eye color exists in a continuous grading from the lightest blue to the darkest brown.
Credit: iStockphoto/Hirlesteanu Constantin-Ciprian

Three new genetic loci have been identified with involvement in subtle and quantitative variation of human eye color.

The study, led by Manfred Kayser of the Erasmus University Medical Center Rotterdam, The Netherlands, is published May 6 in the open-access journal PLoS Genetics.

Previous studies on the genetics of human eye color used broadly-categorized trait information such as 'blue', 'green', and 'brown'; however, variation in eye color exists in a continuous grading from the lightest blue to the darkest brown.

In this genome-wide association study, the eye color of about 6000 Dutch Europeans from the Rotterdam Study was digitally quantified using high-resolution full-eye photographs. This quantitative approach, which is cost-effective, portable, and time efficient, revealed that human eye color varies along more dimensions than are represented by the color categories used previously.

The researchers identified three new loci significantly associated with quantitative eye color. One of these, the LYST gene, was previously considered a pigmentation gene in mice and cattle, whereas the other two had no previous association with pigmentation.

These three genes, together with previously identified ones, explained over 50% of eye color variance, representing the highest accuracy achieved so far in genomic prediction of complex and quantitative human traits.

"These findings are also of relevance for future forensic applications," said Kayser, "where appearance prediction from biological material found at crime scenes may provide investigative leads to trace unknown persons."


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Fan Liu, Andreas Wollstein, Pirro G. Hysi, Georgina A. Ankra-Badu, Timothy D. Spector, Daniel Park, Gu Zhu, Mats Larsson, David L. Duffy, Grant W. Montgomery, David A. Mackey, Susan Walsh, Oscar Lao, Albert Hofman, Fernando Rivadeneira, Johannes R. Vingerling, Andrι G. Uitterlinden, Nicholas G. Martin, Christopher J. Hammond, Manfred Kayser. Digital Quantification of Human Eye Color Highlights Genetic Association of Three New Loci. PLoS Genetics, 2010; 6 (5): e1000934 DOI: 10.1371/journal.pgen.1000934

Cite This Page:

Public Library of Science. "New genes involved in human eye color identified." ScienceDaily. ScienceDaily, 7 May 2010. <www.sciencedaily.com/releases/2010/05/100506172731.htm>.
Public Library of Science. (2010, May 7). New genes involved in human eye color identified. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2010/05/100506172731.htm
Public Library of Science. "New genes involved in human eye color identified." ScienceDaily. www.sciencedaily.com/releases/2010/05/100506172731.htm (accessed August 1, 2014).

Share This




More Health & Medicine News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Quintuplets Head Home

Texas Quintuplets Head Home

Reuters - US Online Video (Aug. 1, 2014) — After four months in the hospital, the first quintuplets to be born at Baylor University Medical Center head home. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Patient Coming to U.S. for Treatment

Ebola Patient Coming to U.S. for Treatment

Reuters - US Online Video (Aug. 1, 2014) — A U.S. aid worker infected with Ebola while working in West Africa will be treated in a high security ward at Emory University in Atlanta. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Vaccine Might Be Coming, But Where's It Been?

Ebola Vaccine Might Be Coming, But Where's It Been?

Newsy (Aug. 1, 2014) — Health officials are working to fast-track a vaccine — the West-African Ebola outbreak has killed more than 700. But why didn't we already have one? Video provided by Newsy
Powered by NewsLook.com
Study Links Certain Birth Control Pills To Breast Cancer

Study Links Certain Birth Control Pills To Breast Cancer

Newsy (Aug. 1, 2014) — Previous studies have made the link between birth control and breast cancer, but the latest makes the link to high-estrogen oral contraceptives. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins