Featured Research

from universities, journals, and other organizations

Caveolin-1 is critical regulator of innate immunity

Date:
May 10, 2010
Source:
American Journal of Pathology
Summary:
Researchers have discovered that caveolin-1 modulation of endothelial nitric oxide synthase (eNOS) activity regulates innate immunity and inflammation-induced lung injury.

A group led by Dr. You-Yang Zhou at the University of Illinois College of Medicine, Chicago, IL have discovered that caveolin-1 modulation of endothelial nitric oxide synthase (eNOS) activity regulates innate immunity and inflammation-induced lung injury. They present these findings in the May 2010 issue of The American Journal of Pathology.

The innate immune system defends the body against infection in a non-specific manner. Nitric oxide, an antimicrobial agent, and eNOS, an enzyme that produces nitric oxide, play a key role in innate immunity and inflammation, as does caveolin-1, a protein involved in cell signaling. An interaction between caveolin-1 and eNOS is thought to be involved in this process.

To determine the respective roles of caveolin-1 and eNOS in innate immunity and inflammation, Mirza et al generated mice that lacked expression of both caveolin-1 and eNOS. They show that eNOS activation inhibited the immune system in caveolin-1-deficient mice, resulting in a decrease in the levels of proinflammatory molecules and improved survival when compared with mice deficient in both caveolin-1 and eNOS. In addition, eNOS activation in caveolin-1-deficient mice protected against inflammation-induced lung injury. The interaction between caveolin-1 and eNOS may therefore represent a new therapeutic target for inflammation and lung injury.

Dr. Zhou's group "present the first genetic evidence of the physiological significance of [caveolin-1] modulation of eNOS activity in regulating [innate immune] signaling. …[They] show that [caveolin-1] modulation of eNOS activity is a key regulator of innate immunity and inflammatory lung injury."


Story Source:

The above story is based on materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Mirza MK, Yuan J, Gao X-P, Garrean S, Brovkovych V, Malik AB, Tiruppathi C, Zhao Y-Y. Caveolin-1 Deficiency Dampens Toll-Like Receptor 4 Signaling through eNOS Activation. American Journal Of Pathology, 2010; 176 (5): 2344 DOI: 10.2353/ajpath.2010.091088

Cite This Page:

American Journal of Pathology. "Caveolin-1 is critical regulator of innate immunity." ScienceDaily. ScienceDaily, 10 May 2010. <www.sciencedaily.com/releases/2010/05/100510141315.htm>.
American Journal of Pathology. (2010, May 10). Caveolin-1 is critical regulator of innate immunity. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/2010/05/100510141315.htm
American Journal of Pathology. "Caveolin-1 is critical regulator of innate immunity." ScienceDaily. www.sciencedaily.com/releases/2010/05/100510141315.htm (accessed October 2, 2014).

Share This



More Health & Medicine News

Thursday, October 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pregnancy Spacing Could Have Big Impact On Autism Risks

Pregnancy Spacing Could Have Big Impact On Autism Risks

Newsy (Oct. 1, 2014) A new study says children born less than one year and more than five years after a sibling can have an increased risk for autism. Video provided by Newsy
Powered by NewsLook.com
Robotic Hair Restoration

Robotic Hair Restoration

Ivanhoe (Oct. 1, 2014) A new robotic procedure is changing the way we transplant hair. The ARTAS robot leaves no linear scarring and provides more natural results. Video provided by Ivanhoe
Powered by NewsLook.com
Insertable Cardiac Monitor

Insertable Cardiac Monitor

Ivanhoe (Oct. 1, 2014) A heart monitor the size of a paperclip that can save your life. The “Reveal Linq” allows a doctor to monitor patients with A-Fib on a continuous basis for up to 3 years! Video provided by Ivanhoe
Powered by NewsLook.com
Attacking Superbugs

Attacking Superbugs

Ivanhoe (Oct. 1, 2014) Two weapons hospitals can use to attack superbugs. Scientists in Ireland created a new gel resistant to superbugs, and a robot that can disinfect a room in minutes. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins