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Caveolin-1 is critical regulator of innate immunity

Date:
May 10, 2010
Source:
American Journal of Pathology
Summary:
Researchers have discovered that caveolin-1 modulation of endothelial nitric oxide synthase (eNOS) activity regulates innate immunity and inflammation-induced lung injury.
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A group led by Dr. You-Yang Zhou at the University of Illinois College of Medicine, Chicago, IL have discovered that caveolin-1 modulation of endothelial nitric oxide synthase (eNOS) activity regulates innate immunity and inflammation-induced lung injury. They present these findings in the May 2010 issue of The American Journal of Pathology.

The innate immune system defends the body against infection in a non-specific manner. Nitric oxide, an antimicrobial agent, and eNOS, an enzyme that produces nitric oxide, play a key role in innate immunity and inflammation, as does caveolin-1, a protein involved in cell signaling. An interaction between caveolin-1 and eNOS is thought to be involved in this process.

To determine the respective roles of caveolin-1 and eNOS in innate immunity and inflammation, Mirza et al generated mice that lacked expression of both caveolin-1 and eNOS. They show that eNOS activation inhibited the immune system in caveolin-1-deficient mice, resulting in a decrease in the levels of proinflammatory molecules and improved survival when compared with mice deficient in both caveolin-1 and eNOS. In addition, eNOS activation in caveolin-1-deficient mice protected against inflammation-induced lung injury. The interaction between caveolin-1 and eNOS may therefore represent a new therapeutic target for inflammation and lung injury.

Dr. Zhou's group "present the first genetic evidence of the physiological significance of [caveolin-1] modulation of eNOS activity in regulating [innate immune] signaling. …[They] show that [caveolin-1] modulation of eNOS activity is a key regulator of innate immunity and inflammatory lung injury."


Story Source:

The above post is reprinted from materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Mirza MK, Yuan J, Gao X-P, Garrean S, Brovkovych V, Malik AB, Tiruppathi C, Zhao Y-Y. Caveolin-1 Deficiency Dampens Toll-Like Receptor 4 Signaling through eNOS Activation. American Journal Of Pathology, 2010; 176 (5): 2344 DOI: 10.2353/ajpath.2010.091088

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American Journal of Pathology. "Caveolin-1 is critical regulator of innate immunity." ScienceDaily. ScienceDaily, 10 May 2010. <www.sciencedaily.com/releases/2010/05/100510141315.htm>.
American Journal of Pathology. (2010, May 10). Caveolin-1 is critical regulator of innate immunity. ScienceDaily. Retrieved August 2, 2015 from www.sciencedaily.com/releases/2010/05/100510141315.htm
American Journal of Pathology. "Caveolin-1 is critical regulator of innate immunity." ScienceDaily. www.sciencedaily.com/releases/2010/05/100510141315.htm (accessed August 2, 2015).

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