A human hepatoma multidrug resistant cell line in vitro
- Date:
- May 12, 2010
- Source:
- World Journal of Gastroenterology
- Summary:
- Drug resistance is still a major impediment in the treatment of cancer. A recent study from China describes the establishment of a multidrug resistant (MDR) cell line, SK-Hep-1/CDDP, which can be used as an in vivo model to investigate the molecular mechanisms involved in MDR-related genes of hepatocarcinoma and to explore the targeted approaches for overcoming MDR in tumor cells.
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Hepatocellular carcinoma (HCC) responds poorly to chemotherapy owing to MDR. Recent studies have shown the tumors derived from the colon, kidney, or adrenal cortex, and HCC exhibited overexpression of MDR1/P-gp. This overexpression results in a primary MDR phenotype of these cancers. Tumor derived cell lines are one of the most important tools for investigation of the biological mechanisms directly leading to drug resistance in patients. Today, the experimental search for drug resistant mechanisms that are clinically relevant targets whose circumvention can improve cancer therapy is still ongoing.
A research, lead by Professor Ling and his colleagues in the Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, has recently been published on May 14, 2010 in the World Journal of Gastroenterology, to represent models for investigating MDR in human HCC. Analysis of novel chemotherapy-resistant cell lines may duplicate the treatment conditions used in vivo.
The new MDR cell line, SK-Hep1/CDDP, can be used as an in vitro model to elucidate the biological mechanisms of MDR in hepatoma, from delineating the process of carcinogenesis through to testing new therapeutic agents. SK-Hep1/CDDP cells can also be used to explore targeted approaches for improving MDR cancer therapy.
Story Source:
Materials provided by World Journal of Gastroenterology. Note: Content may be edited for style and length.
Journal Reference:
- Zhou Y, Ling XL, Li SW, Li XQ, Yan B. Establishment of a human hepatoma multidrug resistant cell line in vitro. World Journal of Gastroenterology, 2010; 16 (18): 2291 DOI: 10.3748/wjg.v16.i18.2291
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