Featured Research

from universities, journals, and other organizations

New model for investigating tobacco/oral cancer link

Date:
May 13, 2010
Source:
New York University
Summary:
Now, a recently completed study has shown that a powerful carcinogen in tobacco smoke can be used for oral cancer research in experimental animals, thus providing a new, more relevant research model with which to understand the initiation, progression, and, ultimately, the prevention of oral cancer.

Although tobacco use is widely understood to be one of the leading causes of oral cancer, research on the prevention of tobacco-related oral cancer in experimental animals has traditionally been limited to examining the impact of synthetic carcinogens manufactured especially for cancer research, rather than on observing the effects of carcinogens that occur in tobacco smoke.

Related Articles


Now, a recently completed study conducted collaboratively by Dr. Joseph Guttenplan, a Professor of Basic Science & Craniofacial Biology at the NYU College of Dentistry, and Dr. Karam El-Bayoumy, a Professor of Biochemistry and Molecular Biology at Penn State University College of Medicine and Associate Director of Basic Research at the Penn State Cancer Institute, has shown that a powerful carcinogen in tobacco smoke can be used for oral cancer research in experimental animals, thus providing a new, more relevant research model with which to understand the initiation, progression, and, ultimately, the prevention of oral cancer. The two-year study was sponsored by the National Institute of Dental and Craniofacial Research, part of the NIH.

In a presentation on April 19 at the 2010 annual meeting of the American Association for Cancer Research (AACR) in Washington, DC, Dr. Guttenplan said the findings could ultimately facilitate research aimed at identifying new approaches to oral cancer prevention.

Oral cancer is a devastating disease that can severely and permanently compromise one's ability to eat, drink, talk, and even kiss. In the United States, about 100 new cases of oral cancer occur each day, and approximately 7,000 people die annually from the disease. Worldwide, over 640,000 new cases of oral cancer occur annually. In addition to tobacco use, alcohol use and exposure to the HPV-16 virus (human papilloma virus version 16) are the leading causes of oral cancer.

The study described in Dr. Guttenplan's presentation examined the impact of injecting low, medium, and high doses of dibenzo[a,l]pyrene, a powerful carcinogen in tobacco, into the mouths of 104 mice. The researchers examined 24 of the mice for mutagenesis and 80 for carcinogenesis. After 38 weeks, all of the mice in the high-dose mutagenesis group developed excessive numbers of mutations in their oral tissue, and within one year, 31% of the high-dose carcinogenesis group displayed large tumors in their mouths.

"As a result of this study," said Dr. Guttenplan, "we now have a model that is significantly better than past models which relied on synthetic carcinogens. "We plan to use this new model in future studies to examine potential agents for cancer prevention."


Story Source:

The above story is based on materials provided by New York University. Note: Materials may be edited for content and length.


Cite This Page:

New York University. "New model for investigating tobacco/oral cancer link." ScienceDaily. ScienceDaily, 13 May 2010. <www.sciencedaily.com/releases/2010/05/100513143542.htm>.
New York University. (2010, May 13). New model for investigating tobacco/oral cancer link. ScienceDaily. Retrieved November 1, 2014 from www.sciencedaily.com/releases/2010/05/100513143542.htm
New York University. "New model for investigating tobacco/oral cancer link." ScienceDaily. www.sciencedaily.com/releases/2010/05/100513143542.htm (accessed November 1, 2014).

Share This



More Health & Medicine News

Saturday, November 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Melafind: Spotting Melanoma Without a Biopsy

Melafind: Spotting Melanoma Without a Biopsy

Ivanhoe (Oct. 31, 2014) The MelaFind device is a pain-free way to check suspicious moles for melanoma, without the need for a biopsy. Video provided by Ivanhoe
Powered by NewsLook.com
Battling Multiple Myeloma

Battling Multiple Myeloma

Ivanhoe (Oct. 31, 2014) The answer isn’t always found in new drugs – repurposing an ‘old’ drug that could mean better multiple myeloma treatment, and hope. Video provided by Ivanhoe
Powered by NewsLook.com
Chronic Inflammation and Prostate Cancer

Chronic Inflammation and Prostate Cancer

Ivanhoe (Oct. 31, 2014) New information that is linking chronic inflammation in the prostate and prostate cancer, which may help doctors and patients prevent cancer in the future. Video provided by Ivanhoe
Powered by NewsLook.com
Sickle Cell: Stopping Kids’ Silent Strokes

Sickle Cell: Stopping Kids’ Silent Strokes

Ivanhoe (Oct. 31, 2014) Blood transfusions are proving crucial to young sickle cell patients by helping prevent strokes, even when there is no outward sign of brain injury. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins