Featured Research

from universities, journals, and other organizations

Bisphenol A and other endocrine-disrupting chemicals pose cancer risk, study suggests

Date:
May 26, 2010
Source:
Tufts University, Health Sciences
Summary:
A review article describes the carcinogenic effects of endocrine-disrupting chemicals, including bisphenol A. Researchers express the need for more complex strategies for studying how these chemicals affect health but report that ample evidence supports changing public health and environmental policies to protect the public, particularly the developing fetus and women of reproductive age.

Longtime environmental health researchers at Tufts University School of Medicine describe the carcinogenic effects of endocrine-disrupting chemicals (EDCs), ubiquitous chemicals that have hormone-like effects in the body. In a review article published online May 25 in Nature Reviews Endocrinology, the researchers express the need for more complex strategies for studying how these chemicals affect health but report that ample evidence already supports changing public health and environmental policies to protect the public from exposure to EDCs.

"The strength and breadth of existing research on the negative effects of EDCs, including bisphenol A, warrants immediate action to reduce EDC exposure, particularly among the developing fetus and women of reproductive age," said author Carlos Sonnenschein, MD, professor in the department of anatomy and cellular biology at Tufts University School of Medicine (TUSM).

"Developing embryos 'read' environmental cues as a forecast of the outside world. These cues can affect the way certain genes are expressed and in this way alter the structure and function of organs. Studies in rodents show that EDCs can cause harm at much lower levels if exposure happens during organ formation as opposed to exposures during adulthood," said author Ana Soto, MD, professor in the department of anatomy and cellular biology at TUSM.

"The evidence indicates that exposure to BPA and other EDCs may contribute to diseases that manifest during adult life, such as increased cancer rates in the industrialized world. These chemicals have also been linked to obesity, altered behavior, and infertility," continued Soto.

The researchers drew several key points from the body of observational, epidemiological, and animal research examining EDCs, emphasizing that embryos display an increased sensitivity to the chemicals. In particular, Soto and Sonnenschein focused on bisphenol A (BPA), a chemical they have spent 15 years investigating. BPA, which is found in plastic bottles, reusable food containers, and food cans, is ubiquitous in industrialized nations and is linked to cancer.

"EDCs act additively and their effects are dependent upon exposure and context, making them inherently complex to study. New mathematical modeling tools and computer simulations will provide a more precise understanding of how these chemicals interact with each other and within the body at different stages of life. That said, we already have ample evidence supporting policies that reduce exposure to EDCs, and we recommend rapid action to diminish these harmful environmental exposures," said Sonnenschein.

In previous animal studies, Soto and Sonnenschein observed that exposure to even trace levels of BPA can increase cancer risk in adulthood. The pair also collaborated in proposing the tissue organization field theory of carcinogenesis and metastasis as an alternative to the currently-held somatic mutation theory, arguing that cancer is a tissue-based disease rather than a cell-based disease as proposed by the somatic mutation theory of carcinogenesis. Both authors are also members of the cell, molecular and developmental biology program faculty at the Sackler School of Graduate Biomedical Sciences at Tufts.

This work was supported by grants from The Parsemus Foundation and the National Institute of Environmental Health Sciences, part of the National Institutes of Health.


Story Source:

The above story is based on materials provided by Tufts University, Health Sciences. Note: Materials may be edited for content and length.


Journal Reference:

  1. Soto AM, Sonnenschein C. Environmental causes of cancer: endocrine disruptors as carcinogens. Nature Reviews Endocrinology, May 25, 2010 DOI: 10.1038/nrendo.2010.87

Cite This Page:

Tufts University, Health Sciences. "Bisphenol A and other endocrine-disrupting chemicals pose cancer risk, study suggests." ScienceDaily. ScienceDaily, 26 May 2010. <www.sciencedaily.com/releases/2010/05/100525103937.htm>.
Tufts University, Health Sciences. (2010, May 26). Bisphenol A and other endocrine-disrupting chemicals pose cancer risk, study suggests. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2010/05/100525103937.htm
Tufts University, Health Sciences. "Bisphenol A and other endocrine-disrupting chemicals pose cancer risk, study suggests." ScienceDaily. www.sciencedaily.com/releases/2010/05/100525103937.htm (accessed August 1, 2014).

Share This




More Health & Medicine News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins