Featured Research

from universities, journals, and other organizations

New source of stem cells form heart muscle cells, repair damage

Date:
May 30, 2010
Source:
American Heart Association
Summary:
A new and noncontroversial source of stem cells can form heart muscle cells and help repair heart damage, according to results of preliminary lab tests.

A new and non-controversial source of stem cells can form heart muscle cells and help repair heart damage, according to results of preliminary lab tests reported in Circulation Research: Journal of the American Heart Association.

Investigators in Japan used the amniotic membrane -- the inner lining of the sac in which an embryo develops -- to obtain stem cells called human amniotic membrane-derived mesenchymal (undifferentiated) cells (hAMCs).

"The amniotic membrane is medical waste that could be collected and used after delivery," said Shunichiro Miyoshi, M.D., Ph.D., co-author of the study and assistant professor in the cardiology department and Institute for Advanced Cardiac Therapeutics at the Keio University School of Medicine in Tokyo.

In laboratory studies, the hAMCs:

  • transformed into heart muscle cells, with 33 percent beating spontaneously.
  • improved function of rat hearts 34 percent to 39 percent when injected two weeks after a heart attack, while untreated hearts continued to decline in function.
  • decreased the scarred area of damaged rat hearts 13 percent to 18 percent when injected after a heart attack.
  • survived for more than four weeks in the rat heart without being rejected by the recipient's immune system, even without immunosuppressive medication.

The ability of hAMCs to convert into heart muscle cells was far greater than that from mesenchymal cells derived from bone marrow or fat, Miyoshi said.

That the implanted cells were not rejected is likely because the amniotic sac is a barrier between a woman and her developing fetus. To help prevent either of their immune systems from attacking the other as foreign tissue, the amniotic membrane between them does not produce the proteins that immune systems use to identify foreign tissue. This means the usual tissue-type matching (HLA typing) needed prior to transplantation would not be needed if hAMCs were used. Drugs to suppress the immune system also might not be needed after transplant.

The findings also suggest that hAMCs can differentiate into cells of various organs.

"If we had to create a cell bank system to cover every HLA type, we would need to store a great amount of cells, many of which would never be used," Miyoshi said. "Because hAMCs do not require such a system, it would be less expensive and usable for all patients."

Much work remains to be done before testing hAMCs in humans, said the researchers, who are repeating their experiments in larger animals and working to boost the number of heart cells generated by the hAMCs.

The investigators "are to be congratulated for their careful work that has brought forward a cell type that may offer the real potential for off-the-shelf cardiac myocyte [muscle cell]-based therapy," Marc S. Penn, M.D., Ph.D., and Maritza E. Mayorga, Ph.D., of the Cleveland Clinic, wrote in an editorial in Circulation Research.

The lead author is Hiroko Tsuji, M.D. Other co-authors are: Yukinori Ikegami, M.D.; Naoko Hida; Hironori Asada, M.D.; Ikuko Togashi, M.D.; Junshi Suzuki, M.D.; Masaki Satake, Ph.D.; Hikaru Nakamizo, M.D.; Mamoru Tanaka, M.D.; Taisuke Mori, M.D., Ph.D.; Kaoru Segawa, Ph.D.; Nabuhiro Nishiyama, M.D.; Junko Inoue; Hatsune Makino, Ph.D.; Kenji Miyado, Ph.D.; Satoshi Ogawa, M.D., Ph.D.; Yasunori Yoshimura, M.D., Ph.D. and Akhiro Umezawa, M.D., Ph.D.

The study was partly funded by Japan's Ministry of Education, Science and Culture.


Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Journal Reference:

  1. H. Tsuji, S. Miyoshi, Y. Ikegami, N. Hida, H. Asada, I. Togashi, J. Suzuki, M. Satake, H. Nakamizo, M. Tanaka, T. Mori, K. Segawa, N. Nishiyama, J. Inoue, H. Makino, K. Miyado, S. Ogawa, Y. Yoshimura, A. Umezawa. Xenografted Human Amniotic Membrane-Derived Mesenchymal Stem Cells Are Immunologically Tolerated and Transdifferentiated Into Cardiomyocytes. Circulation Research, 2010; 106 (10): 1613 DOI: 10.1161/CIRCRESAHA.109.205260

Cite This Page:

American Heart Association. "New source of stem cells form heart muscle cells, repair damage." ScienceDaily. ScienceDaily, 30 May 2010. <www.sciencedaily.com/releases/2010/05/100528210730.htm>.
American Heart Association. (2010, May 30). New source of stem cells form heart muscle cells, repair damage. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2010/05/100528210730.htm
American Heart Association. "New source of stem cells form heart muscle cells, repair damage." ScienceDaily. www.sciencedaily.com/releases/2010/05/100528210730.htm (accessed October 23, 2014).

Share This



More Health & Medicine News

Thursday, October 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins