Featured Research

from universities, journals, and other organizations

Researchers develop test to identify 'best' sperm

Date:
May 31, 2010
Source:
Yale University
Summary:
Researchers have discovered a method to select sperm with the highest DNA integrity in a bid to improve male fertility. The method is comparable to that of the egg's natural selection abilities, according to their study.

A circle of hyaluronic acid selects all the good sperm with high DNA integrity and fertilizing potential.
Credit: Image courtesy of Yale University

Researchers at Yale School of Medicine have discovered a method to select sperm with the highest DNA integrity in a bid to improve male fertility. The method is comparable to that of the egg's natural selection abilities, according to the study published in the June/July issue of the Journal of Andrology.

Related Articles


"Our results could help address the fact that approximately 40 percent of infertility cases can be traced to male infertility," said the senior author of the study, Gabor Huszar, M.D., director of the Sperm Physiology Lab and senior research scientist in the Department of Obstetrics, Gynecology & Reproductive Sciences at Yale.

Huszar said that past semen analysis focused on sperm concentration and motility. It was assumed that if a man had a high sperm count and active sperm, that he was fertile. But there was no information on the sperm's fertility or its ability to attach to its mark, the female gamete. In an ideal case, the egg naturally selects the optimal sperm, but during in-vitro fertilization treatment of men who had only a few sperm, clinicians did not know whether they were injecting the correct sperm into the egg for fertilization. "We have now found a biochemical marker of sperm fertility so that we can select sperm with high genetic integrity," Huszar said.

Huszar and his colleagues tested the idea that binding sperm to hyaluronic acid selects sperm with high DNA integrity. They studied semen samples from 50 men, and a part of the sperm in the semen was allowed to bind to hyaluronic acid. These sperm were isolated, and the DNA chain integrity was compared to the original sperm in semen. The team used a reagent that stained sperm with high DNA integrity green, whereas sperm with fragmented DNA, and diminished DNA integrity were stained red.

"The sperm with fragmented DNA work like scratched CDs," Huszar said. "They seem to be operational, but when you play them, some of the information is missing. These damaged sperm may also carry chromosomal aberrations that could be related to genetic diseases." Huszar and his colleagues identified the nuclear and cytoplasmic attributes of various sperm. They also identified a key relationship between the ability of sperm to bind to hyaluronic acid and between high sperm genetic integrity, which enhances the sperm's contribution to normal embryo development.

"When sperm is selected with hyaluronic acid binding, they are of comparable, if not better, overall quality than sperm chosen by the oocyte in the natural fertilization process," said Huszar.


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Artay Yagci, William Murk, Jill Stronk, and Gabor Huszar. Spermatozoa Bound to Solid State Hyaluronic Acid Show Chromatin Structure with High DNA Chain Integrity: An Acridine Orange Fluorescence Study. Journal of Andrology, 2010; DOI: 10.2164/jandrol.109.008912

Cite This Page:

Yale University. "Researchers develop test to identify 'best' sperm." ScienceDaily. ScienceDaily, 31 May 2010. <www.sciencedaily.com/releases/2010/05/100528211202.htm>.
Yale University. (2010, May 31). Researchers develop test to identify 'best' sperm. ScienceDaily. Retrieved March 29, 2015 from www.sciencedaily.com/releases/2010/05/100528211202.htm
Yale University. "Researchers develop test to identify 'best' sperm." ScienceDaily. www.sciencedaily.com/releases/2010/05/100528211202.htm (accessed March 29, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, March 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) — The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins