Featured Research

from universities, journals, and other organizations

Scientists move closer to pinpointing gene involved in bowel cancer spread

Date:
June 2, 2010
Source:
BMJ-British Medical Journal
Summary:
Scientists may be on the cusp of pinpointing a gene that is involved in the progression and spread of bowel cancer, new research indicates.

Scientists may be on the cusp of pinpointing a gene that is involved in the progression and spread of bowel cancer, indicates research published ahead of print in the Journal of Medical Genetics.

Related Articles


If proved correct, the discovery could open up the possibility of new preventive or treatment options, say the authors.

Bowel cancer is the third most common cancer in the UK and the second leading cause of cancer death in the US.

Up to a third of bowel cancer cases are thought to be linked to inherited genetic factors, but in 25% of cases the genetic faults/variants are not known.

The researchers analysed the genetic profiles of a large family of 81 members spanning five generations, whose details were entered on the Utah Population Database.

This genealogical database holds 7.5 million records, linked to other important health data, including state-wide cancer registries.

This particular family did not have the genetic faults/variations associated with the known inherited syndromes implicated in 5% of bowel cancers.

Instead, genetic analysis identified the long arm of chromosome 13 (13q), which was significantly associated with the incidence of bowel polyps (precancerous growths) or bowel cancer among family members.

Three family members had bowel cancer, two of which had already spread to other parts of the body when they were diagnosed at the ages of 42 and 35. A further nine family members and two spouses had bowel polyps.

Although 13q has not yet been identified as being linked to bowel cancer, this chromosome is often overexpressed in 30%-50% of primary bowel cancers, say the authors.

Genes within this chromosome are thought to play a key role in the progression and spread of bowel cancer, but none has been precisely identified as yet.

This is backed up by the finding that simple polyps seem to have rapidly advanced to invasive bowel cancer in this family as none had the intermediate type of polyp.

Once a gene has been identified and it is also found to be involved in sporadic rather than inherited cases of bowel cancer, it opens up the potential for new preventive and treatment approaches, say the authors.


Story Source:

The above story is based on materials provided by BMJ-British Medical Journal. Note: Materials may be edited for content and length.


Cite This Page:

BMJ-British Medical Journal. "Scientists move closer to pinpointing gene involved in bowel cancer spread." ScienceDaily. ScienceDaily, 2 June 2010. <www.sciencedaily.com/releases/2010/06/100602193322.htm>.
BMJ-British Medical Journal. (2010, June 2). Scientists move closer to pinpointing gene involved in bowel cancer spread. ScienceDaily. Retrieved December 18, 2014 from www.sciencedaily.com/releases/2010/06/100602193322.htm
BMJ-British Medical Journal. "Scientists move closer to pinpointing gene involved in bowel cancer spread." ScienceDaily. www.sciencedaily.com/releases/2010/06/100602193322.htm (accessed December 18, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, December 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Kids Die While Under Protective Services

Kids Die While Under Protective Services

AP (Dec. 18, 2014) As part of a six-month investigation of child maltreatment deaths, the AP found that hundreds of deaths from horrific abuse and neglect could have been prevented. AP's Haven Daley reports. (Dec. 18) Video provided by AP
Powered by NewsLook.com
UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
Why Your Boss Should Let You Sleep In

Why Your Boss Should Let You Sleep In

Newsy (Dec. 17, 2014) According to research out of the University of Pennsylvania, waking up for work is the biggest factor that causes Americans to lose sleep. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins