Featured Research

from universities, journals, and other organizations

Key regulator of fat cell development identified

Date:
June 6, 2010
Source:
UCD Conway Institute of Biomolecular & Biomedical Research
Summary:
New research has identified a key regulator of fat cell differentiation that may be a novel target for obesity drugs.

New research led by UCD Conway Fellow, Professor Johan Ericsson has identified a key regulator of fat cell differentiation that may be a novel target for obesity drugs.

The results of the research are published in the current edition of the scientific journal, Proceedings of the National Academy of Sciences (PNAS).

Adipose tissue plays an important role in controlling the balance of insulin in our bodies as well as energy production and consumption. White adipose tissue is a storage depot for excess energy in the form of fat. Excessive adipocyte (fat cell) size and/or number is a hallmark of obesity, which is a major risk factor for developing type-II diabetes, cardiovascular disease and hypertension.

Professor Ericsson and his team have demonstrated that the protein Fbxw7 regulates the cascade of events that control the development of fat cells. They found that when Fbxw7 was inactive, the development of fat cells was enhanced. In fact, in the case of mouse precursor or immature fat cells, the inactivation of this protein alone was enough to convert them to mature fat cells. The team also demonstrated that Fbxw7 blocks the development of fat cells because it tags other proteins in the regulatory cascade for destruction.

Commenting on the results, Professor Ericsson said; 'The picture we have built of the role of Fbxw7 in energy and lipid metabolism suggests that it is a key regulator of this process. As such, it may impact on two very important health problems, type-II diabetes and obesity'.

In the future, the group would like to determine exactly how Fbxw7 regulates adipocyte differentiation, and identify the factors and signals that control the amount of this protein in fat cells. It will also be important to determine if the levels of Fbxw7 are changed during the development of obesity.

In Ireland, an estimated 200,000 people are suffering from type-II diabetes and it is anticipated that this will rise by 37% in the coming years. This places an enormous burden on the national healthcare budget as people are treated for the disease and its complications.

Johan Ericsson is a Science Foundation Ireland funded Stokes professor. Prior to joining UCD Conway Institute in 2009, he worked at the Ludwig Institute for Cancer Research in Sweden.


Story Source:

The above story is based on materials provided by UCD Conway Institute of Biomolecular & Biomedical Research. Note: Materials may be edited for content and length.


Journal Reference:

  1. M. T. Bengoechea-Alonso, J. Ericsson. The ubiquitin ligase Fbxw7 controls adipocyte differentiation by targeting C/EBP for degradation. Proceedings of the National Academy of Sciences, 2010; DOI: 10.1073/pnas.0913367107

Cite This Page:

UCD Conway Institute of Biomolecular & Biomedical Research. "Key regulator of fat cell development identified." ScienceDaily. ScienceDaily, 6 June 2010. <www.sciencedaily.com/releases/2010/06/100603091817.htm>.
UCD Conway Institute of Biomolecular & Biomedical Research. (2010, June 6). Key regulator of fat cell development identified. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/2010/06/100603091817.htm
UCD Conway Institute of Biomolecular & Biomedical Research. "Key regulator of fat cell development identified." ScienceDaily. www.sciencedaily.com/releases/2010/06/100603091817.htm (accessed April 24, 2014).

Share This



More Health & Medicine News

Thursday, April 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Fungus Killing Bats, Spreading in US

Deadly Fungus Killing Bats, Spreading in US

AP (Apr. 24, 2014) A disease that has killed more than six million cave-dwelling bats in the United States is on the move and wildlife biologists are worried. White Nose Syndrome, discovered in New York in 2006, has now spread to 25 states. (April 24) Video provided by AP
Powered by NewsLook.com
Companies Ramp Up Wellness to Lower Health Costs

Companies Ramp Up Wellness to Lower Health Costs

AP (Apr. 24, 2014) That little voice telling you to exercise, get in shape and get healthy is probably coming from your boss. More companies are beefing up wellness programs to try and cut down their health care costs. (April 24) Video provided by AP
Powered by NewsLook.com
FDA Wants To Ban Sales Of E-Cigarettes To Minors

FDA Wants To Ban Sales Of E-Cigarettes To Minors

Newsy (Apr. 24, 2014) The Food and Drug Administration wants to crack down on the use of e-cigarettes, banning the sale of the product to minors. Video provided by Newsy
Powered by NewsLook.com
Michigan Man Sees Thanks to 'bionic Eye'

Michigan Man Sees Thanks to 'bionic Eye'

AP (Apr. 23, 2014) A legally blind Michigan man is 'seeing something new every day' thanks to a high-tech retinal implant procedure. He's one of the first in the country to receive a 'bionic eye' since the federal government approved the surgery. (April 23) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins