Featured Research

from universities, journals, and other organizations

Acute toxicity predicts overall survival in high-grade gliomas

Date:
June 9, 2010
Source:
Thomas Jefferson University
Summary:
Patients with high-grade gliomas who experience acute (early) neurological toxicity during their treatment were more likely to experience chronic (late) neurological toxicity and shortened overall survival, according to researchers in a new study.

Patients with high-grade gliomas who experience acute (early) neurological toxicity during their treatment were more likely to experience chronic (late) neurological toxicity and shortened overall survival, according to researchers from the Kimmel Cancer Center at Jefferson.

The study will be presented at the 2010 ASCO Annual Meeting in Chicago (Abstract #2037).

Yaacov Lawrence, M.D., assistant professor of Radiation Oncology at Jefferson Medical College of Thomas Jefferson University, and colleagues at the Radiation Therapy Oncology Group (RTOG) used the RTOG database to identify 2,610 patients with high-grade glioma who participated in clinical trials from 1983 to 2003. Toxicity and outcome data were analyzed for all subjects.

All of the patients had received fractionated radiation therapy to treat their brain cancers. The researchers observed 182 acute neurological toxicity events. On a multivariate analysis, poor performance status, more aggressive surgery, poor neurological function and cognitive impairment were associated with increased acute neurological toxicity.

Acute neurological toxicity was significantly associated with chronic neurological toxicity. It was also found to predict overall survival: 7.8 months in patients who experienced acute neurological toxicity vs. 11.8 months in patients who did not.

"As brain tumor patients begin living longer thanks to modern therapeutics, treatment-related side effects become more important," Dr. Lawrence said. "Traditional cancer trials have emphasized tumor control as a means to increase overall survival. Our study emphasizes the association of treatment side effects with long-term outcomes. This novel finding is yet to be fully explained. The bottom line is that we have to be especially careful with patients who experience significant toxicity during treatment. Conversely, we can reassure those patients who have a smooth ride through radiation therapy that they are likely to do above average."


Story Source:

The above story is based on materials provided by Thomas Jefferson University. Note: Materials may be edited for content and length.


Cite This Page:

Thomas Jefferson University. "Acute toxicity predicts overall survival in high-grade gliomas." ScienceDaily. ScienceDaily, 9 June 2010. <www.sciencedaily.com/releases/2010/06/100607101806.htm>.
Thomas Jefferson University. (2010, June 9). Acute toxicity predicts overall survival in high-grade gliomas. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2010/06/100607101806.htm
Thomas Jefferson University. "Acute toxicity predicts overall survival in high-grade gliomas." ScienceDaily. www.sciencedaily.com/releases/2010/06/100607101806.htm (accessed September 30, 2014).

Share This



More Health & Medicine News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How 'Yes Means Yes' Defines Sexual Assault

How 'Yes Means Yes' Defines Sexual Assault

Newsy (Sep. 29, 2014) Aimed at reducing sexual assaults on college campuses, California has adopted a new law changing the standard of consent for sexual activity. Video provided by Newsy
Powered by NewsLook.com
Scientists May Have Found An Early Sign Of Pancreatic Cancer

Scientists May Have Found An Early Sign Of Pancreatic Cancer

Newsy (Sep. 29, 2014) Researchers looked at 1,500 blood samples and determined people who developed pancreatic cancer had more branched chain amino acids. Video provided by Newsy
Powered by NewsLook.com
Colo. Doctors See Cluster of Enterovirus Cases

Colo. Doctors See Cluster of Enterovirus Cases

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com
Dr.'s Unsure of Cause of Fast-Spreading Virus

Dr.'s Unsure of Cause of Fast-Spreading Virus

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins