Featured Research

from universities, journals, and other organizations

Acute toxicity predicts overall survival in high-grade gliomas

Date:
June 9, 2010
Source:
Thomas Jefferson University
Summary:
Patients with high-grade gliomas who experience acute (early) neurological toxicity during their treatment were more likely to experience chronic (late) neurological toxicity and shortened overall survival, according to researchers in a new study.

Patients with high-grade gliomas who experience acute (early) neurological toxicity during their treatment were more likely to experience chronic (late) neurological toxicity and shortened overall survival, according to researchers from the Kimmel Cancer Center at Jefferson.

Related Articles


The study will be presented at the 2010 ASCO Annual Meeting in Chicago (Abstract #2037).

Yaacov Lawrence, M.D., assistant professor of Radiation Oncology at Jefferson Medical College of Thomas Jefferson University, and colleagues at the Radiation Therapy Oncology Group (RTOG) used the RTOG database to identify 2,610 patients with high-grade glioma who participated in clinical trials from 1983 to 2003. Toxicity and outcome data were analyzed for all subjects.

All of the patients had received fractionated radiation therapy to treat their brain cancers. The researchers observed 182 acute neurological toxicity events. On a multivariate analysis, poor performance status, more aggressive surgery, poor neurological function and cognitive impairment were associated with increased acute neurological toxicity.

Acute neurological toxicity was significantly associated with chronic neurological toxicity. It was also found to predict overall survival: 7.8 months in patients who experienced acute neurological toxicity vs. 11.8 months in patients who did not.

"As brain tumor patients begin living longer thanks to modern therapeutics, treatment-related side effects become more important," Dr. Lawrence said. "Traditional cancer trials have emphasized tumor control as a means to increase overall survival. Our study emphasizes the association of treatment side effects with long-term outcomes. This novel finding is yet to be fully explained. The bottom line is that we have to be especially careful with patients who experience significant toxicity during treatment. Conversely, we can reassure those patients who have a smooth ride through radiation therapy that they are likely to do above average."


Story Source:

The above story is based on materials provided by Thomas Jefferson University. Note: Materials may be edited for content and length.


Cite This Page:

Thomas Jefferson University. "Acute toxicity predicts overall survival in high-grade gliomas." ScienceDaily. ScienceDaily, 9 June 2010. <www.sciencedaily.com/releases/2010/06/100607101806.htm>.
Thomas Jefferson University. (2010, June 9). Acute toxicity predicts overall survival in high-grade gliomas. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/2010/06/100607101806.htm
Thomas Jefferson University. "Acute toxicity predicts overall survival in high-grade gliomas." ScienceDaily. www.sciencedaily.com/releases/2010/06/100607101806.htm (accessed March 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Solitair Device Aims to Takes Guesswork out of Sun Safety

Solitair Device Aims to Takes Guesswork out of Sun Safety

Reuters - Innovations Video Online (Mar. 31, 2015) — The Solitair device aims to take the confusion out of how much sunlight we should expose our skin to. Small enough to be worn as a tie or hair clip, it monitors the user&apos;s sun exposure by taking into account their skin pigment, location and schedule. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins