Featured Research

from universities, journals, and other organizations

Obstacles to stem cell therapy cleared

Date:
June 13, 2010
Source:
Lund University
Summary:
Researchers in Sweden have come up with a new technique to prevent tumors developing in connection with stem cell transplantations.

Researchers at Lund University have come up with a new technique to prevent tumours developing in connection with stem cell transplantations.

The results have been published in the scientific journal Proceedings of the National Academy of Sciences.

"When you develop, for example, nerve cells for transplantation, you always get a small contamination of immature stem cells," explains Johan Jakobsson, head of research group at the Department of Experimental Medical Science.

These immature stem cells can lead to tumours -- an unacceptable side-effect.

"We have developed a technique that enables us to eliminate immature stem cells and thus create safer stem cell transplantations."

The researchers have transplanted the stem cells into mice with Parkinson's disease. The results are very promising: there are far fewer tumours and the cells that survive are the correct type of nerve cells.

The technique uses a specially designed virus.

"We use the virus to genetically modify the cells, which means that we can see which ones we want and which ones we don't want. You could say that we hijack one of the cell's gene regulation systems, microRNA. The cell itself tells us when it is mature; it is black when it is immature and turns green when it has completed its development."

It is relatively simple to isolate, cultivate, preserve and genetically modify stem cells. If transplanted into humans they could replace damaged tissue in the nervous system and support other cells that work to heal a brain injury.

"For us this is a major step. Previously tumours have always developed with this type of transplantation. Now we have shown that this can be avoided," says Johan Jakobsson.

At Lund University collaborations are underway on stem cell therapy, for example, for Parkinson's disease, diabetes, stroke, leukaemia and breast cancer. The research community has set the goal of making stem-cell based treatment effective and safe for at least one of the diseases within the next 10 years.

"Our technique could in theory be used for all these diseases," says Johan Jakobsson. The next step is to conduct experiments on human cell lines.

This project is a collaboration within the Bagadilico research network.


Story Source:

The above story is based on materials provided by Lund University. Note: Materials may be edited for content and length.


Journal Reference:

  1. R. Sachdeva, M. E. Jonsson, J. Nelander, A. Kirkeby, C. Guibentif, B. Gentner, L. Naldini, A. Bjorklund, M. Parmar, J. Jakobsson. Tracking differentiating neural progenitors in pluripotent cultures using microRNA-regulated lentiviral vectors. Proceedings of the National Academy of Sciences, 2010; DOI: 10.1073/pnas.1006568107

Cite This Page:

Lund University. "Obstacles to stem cell therapy cleared." ScienceDaily. ScienceDaily, 13 June 2010. <www.sciencedaily.com/releases/2010/06/100608211604.htm>.
Lund University. (2010, June 13). Obstacles to stem cell therapy cleared. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2010/06/100608211604.htm
Lund University. "Obstacles to stem cell therapy cleared." ScienceDaily. www.sciencedaily.com/releases/2010/06/100608211604.htm (accessed September 17, 2014).

Share This



More Health & Medicine News

Wednesday, September 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Man Floats for 31 Hours in Gulf Waters

Man Floats for 31 Hours in Gulf Waters

AP (Sep. 16, 2014) A Texas man is lucky to be alive after he and three others floated for more than a day in the Gulf of Mexico when their boat sank during a fishing trip. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

AFP (Sep. 16, 2014) Since the arrival of Ebola in Ivory Coast, Ivorians have been abandoning their pets, particularly monkeys, in the fear that they may transmit the virus. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com
Study Links Male-Pattern Baldness To Prostate Cancer

Study Links Male-Pattern Baldness To Prostate Cancer

Newsy (Sep. 16, 2014) New findings suggest men with a certain type of baldness at age 45 are 39 percent more likely to develop aggressive prostate cancer. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

      Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins