Featured Research

from universities, journals, and other organizations

Obstacles to stem cell therapy cleared

Date:
June 13, 2010
Source:
Lund University
Summary:
Researchers in Sweden have come up with a new technique to prevent tumors developing in connection with stem cell transplantations.

Researchers at Lund University have come up with a new technique to prevent tumours developing in connection with stem cell transplantations.

The results have been published in the scientific journal Proceedings of the National Academy of Sciences.

"When you develop, for example, nerve cells for transplantation, you always get a small contamination of immature stem cells," explains Johan Jakobsson, head of research group at the Department of Experimental Medical Science.

These immature stem cells can lead to tumours -- an unacceptable side-effect.

"We have developed a technique that enables us to eliminate immature stem cells and thus create safer stem cell transplantations."

The researchers have transplanted the stem cells into mice with Parkinson's disease. The results are very promising: there are far fewer tumours and the cells that survive are the correct type of nerve cells.

The technique uses a specially designed virus.

"We use the virus to genetically modify the cells, which means that we can see which ones we want and which ones we don't want. You could say that we hijack one of the cell's gene regulation systems, microRNA. The cell itself tells us when it is mature; it is black when it is immature and turns green when it has completed its development."

It is relatively simple to isolate, cultivate, preserve and genetically modify stem cells. If transplanted into humans they could replace damaged tissue in the nervous system and support other cells that work to heal a brain injury.

"For us this is a major step. Previously tumours have always developed with this type of transplantation. Now we have shown that this can be avoided," says Johan Jakobsson.

At Lund University collaborations are underway on stem cell therapy, for example, for Parkinson's disease, diabetes, stroke, leukaemia and breast cancer. The research community has set the goal of making stem-cell based treatment effective and safe for at least one of the diseases within the next 10 years.

"Our technique could in theory be used for all these diseases," says Johan Jakobsson. The next step is to conduct experiments on human cell lines.

This project is a collaboration within the Bagadilico research network.


Story Source:

The above story is based on materials provided by Lund University. Note: Materials may be edited for content and length.


Journal Reference:

  1. R. Sachdeva, M. E. Jonsson, J. Nelander, A. Kirkeby, C. Guibentif, B. Gentner, L. Naldini, A. Bjorklund, M. Parmar, J. Jakobsson. Tracking differentiating neural progenitors in pluripotent cultures using microRNA-regulated lentiviral vectors. Proceedings of the National Academy of Sciences, 2010; DOI: 10.1073/pnas.1006568107

Cite This Page:

Lund University. "Obstacles to stem cell therapy cleared." ScienceDaily. ScienceDaily, 13 June 2010. <www.sciencedaily.com/releases/2010/06/100608211604.htm>.
Lund University. (2010, June 13). Obstacles to stem cell therapy cleared. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/2010/06/100608211604.htm
Lund University. "Obstacles to stem cell therapy cleared." ScienceDaily. www.sciencedaily.com/releases/2010/06/100608211604.htm (accessed October 2, 2014).

Share This



More Health & Medicine News

Thursday, October 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pregnancy Spacing Could Have Big Impact On Autism Risks

Pregnancy Spacing Could Have Big Impact On Autism Risks

Newsy (Oct. 1, 2014) A new study says children born less than one year and more than five years after a sibling can have an increased risk for autism. Video provided by Newsy
Powered by NewsLook.com
Robotic Hair Restoration

Robotic Hair Restoration

Ivanhoe (Oct. 1, 2014) A new robotic procedure is changing the way we transplant hair. The ARTAS robot leaves no linear scarring and provides more natural results. Video provided by Ivanhoe
Powered by NewsLook.com
Insertable Cardiac Monitor

Insertable Cardiac Monitor

Ivanhoe (Oct. 1, 2014) A heart monitor the size of a paperclip that can save your life. The “Reveal Linq” allows a doctor to monitor patients with A-Fib on a continuous basis for up to 3 years! Video provided by Ivanhoe
Powered by NewsLook.com
Attacking Superbugs

Attacking Superbugs

Ivanhoe (Oct. 1, 2014) Two weapons hospitals can use to attack superbugs. Scientists in Ireland created a new gel resistant to superbugs, and a robot that can disinfect a room in minutes. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins