Featured Research

from universities, journals, and other organizations

Optical imaging could create pathway for radiotracers, study finds

Date:
July 6, 2010
Source:
Society of Nuclear Medicine
Summary:
A new study reports on investigative research of a novel optical imaging technique called "Cerenkov luminescence imaging." According to the authors, the technique could lead to the faster and more cost-effective development of radiopharmaceuticals for the diagnosis and treatment of cancer and other conditions.

A study published in the July issue of The Journal of Nuclear Medicine (JNM) reports on investigative research of a novel optical imaging technique called "Cerenkov luminescence imaging (CLI)." According to the authors, the technique could lead to the faster and more cost-effective development of radiopharmaceuticals for the diagnosis and treatment of cancer and other conditions.

Related Articles


"The development of novel multimodality imaging agents and techniques could represent the frontier of research in the field of medical imaging science," said Jan Grimm, M.D., Ph.D., a professor and physician at Memorial Sloan-Kettering Cancer Center and Weill Cornell Medical Center in New York and corresponding author for the study. Grimm explained that his group's work, along with current work from groups at the University of California Davis (Simon Cherry, Ph.D.) and Stanford University (Sanjiv Sam Gambhir, M.D., Ph.D.), may open a new path for optical imaging to move into the clinic.

When light travels through water, its speed decreases. A particle that moves faster than light in water produces a "shock wave" (much like the sonic boom that broke the sound barrier), which emits a visible blue light known as "Cerenkov radiation." The researchers write that their study is among the first to explore Cerenkov radiation's applications for medical imaging using optical imaging techniques.

Optical imaging is a molecular imaging procedure in which light-producing molecules designed to attach to specific cells or molecules are injected into the bloodstream and then detected by an optical imaging device. It usually requires either excitation by an external light source or by a biological process. Cerenkov imaging produces the light from the radioactivity, so no external illumination is needed. Combining optical imaging with nuclear medicine presents a new path for imaging medical isotopes, Grimm said. "It provides optical imaging with an array of approved nuclear tracers already in clinical use today, which can be used immediately, as opposed to fluorescent dyes," he added.

For the study, researchers evaluated several radionuclides for potential use with CLI. Researchers used CLI and positron-emission tomography (PET) imaging to visualize tumor-bearing mice. The results show that CLI visualizes radiotracer uptake in vivo. The resulting decrease of light over time correlates with the radioactive decay of the injected tracer.

An added value of this technique is its ability to image radionuclides that do not emit either positrons or gamma rays -- a current limitation for nuclear imaging modalities. CLI brings to light isotopes that could not be visualized previously. Additionally, optical imaging techniques show promise for endoscopy and surgery because of the ability to visualize tumor lesions, which could provide real-time information to surgeons and help guide operations.

"The benefits of optical imaging are numerous, and we're on a path to realizing them," said Grimm. "We are optimistic that these new techniques will one day be available to physicians as another tool for the diagnosis and treatment of disease."

Authors of the study include: Alessandro Ruggiero, Jan Grimm, Nuclear Medicine Service, Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, New York; Jason P. Holland, Jason S. Lewis, Radiochemistry Service, Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, New York; Jason S. Lewis, Jan Grimm, Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, New York.


Story Source:

The above story is based on materials provided by Society of Nuclear Medicine. Note: Materials may be edited for content and length.


Journal Reference:

  1. A. Ruggiero, J. P. Holland, J. S. Lewis, J. Grimm. Cerenkov Luminescence Imaging of Medical Isotopes. Journal of Nuclear Medicine, 2010; DOI: 10.2967/jnumed.110.076521

Cite This Page:

Society of Nuclear Medicine. "Optical imaging could create pathway for radiotracers, study finds." ScienceDaily. ScienceDaily, 6 July 2010. <www.sciencedaily.com/releases/2010/07/100701103401.htm>.
Society of Nuclear Medicine. (2010, July 6). Optical imaging could create pathway for radiotracers, study finds. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2010/07/100701103401.htm
Society of Nuclear Medicine. "Optical imaging could create pathway for radiotracers, study finds." ScienceDaily. www.sciencedaily.com/releases/2010/07/100701103401.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Reuters - Innovations Video Online (Dec. 21, 2014) A team of scientists led by Danish chemist Jorn Christensen says they have isolated two chemical compounds within an existing antipsychotic medication that could be used to help a range of failing antibiotics work against killer bacterial infections, such as Tuberculosis. Jim Drury went to meet him. Video provided by Reuters
Powered by NewsLook.com
Hugging It Out Could Help You Ward Off A Cold

Hugging It Out Could Help You Ward Off A Cold

Newsy (Dec. 21, 2014) Carnegie Mellon researchers found frequent hugs can help people avoid stress-related illnesses. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins