Featured Research

from universities, journals, and other organizations

HPV DNA testing over 50 percent more sensitive than cytology testing

Date:
July 8, 2010
Source:
Queen Mary, University of London
Summary:
HPV DNA testing for pre-cancers and cervical cancers is over 50 per cent more sensitive than cytology testing for the same conditions a community-based study in Mexico has revealed. Results of the largest HPV DNA primary screening study ever to be performed in a Latin American country point to the readiness of HPV DNA testing for large-scale implementation in Mexico and are published online today in Cancer, Causes and Controls.

HPV DNA testing for precancers and cervical cancers is over 50 per cent more sensitive than cytology testing for the same conditions a community-based study in Mexico has revealed. Results of the largest HPV DNA primary screening study ever to be performed in a Latin American country point to the readiness of HPV DNA testing for large-scale implementation in Mexico have just been published.

Attila Lorincz, Professor of Molecular Epidemiology at Barts and The London School of Medicine and Dentistry is among researchers behind the study which involved over 50,000 women, aged 20-70, undergoing routine cytology and high risk (HR) HPV DNA testing. All those who tested positive through cytology were referred to colposcopy, while the HPV DNA positive women were followed by repeat HPV DNA testing with colposcopy if they were repeat positive in one year. The study is a pilot implementation to determine the real world performance of routine HPV DNA testing and routine cytology testing in the Mexican IMSS health insurance system.

In women who were both cytology and HPV DNA positive the rate of precancer or cancer was 19.7 per cent whereas the corresponding rate in women who were positive by cytology alone was only 3 per cent. In women who were positive twice for HR HPV DNA (regarded as HPV persistent) the rate of precancer and/or cancers was 11.7 per cent.

Overall the sensitivity of HPV DNA testing for precancers and cervical cancers was 93.3 per cent versus only 40 per cent for cytology testing.

Professor Lorincz said of the results: "The data confirms that HR-HPV DNA testing is much more sensitive than cytology and that HPV testing also identifies women with high risk of serious cervical disease in an efficient and medically acceptable manner.

"The advantage of this new cervical cancer screening approach is that women who are HPV DNA positive can be quickly referred to colposcopy (within one year), thus catching the vast majority of the precancers and cancers. In contrast women who are HPV DNA negative can be safely made subject to much longer screening intervals (5 to 10 years) saving considerable costs for the Mexican health system. "

'A pilot study of HPV DNA and cytology testing in 50,159 women in the routine Mexican Social Security Program,' is published online July 8, 2010 in Cancer Causes & Control.


Story Source:

The above story is based on materials provided by Queen Mary, University of London. Note: Materials may be edited for content and length.


Cite This Page:

Queen Mary, University of London. "HPV DNA testing over 50 percent more sensitive than cytology testing." ScienceDaily. ScienceDaily, 8 July 2010. <www.sciencedaily.com/releases/2010/07/100708111330.htm>.
Queen Mary, University of London. (2010, July 8). HPV DNA testing over 50 percent more sensitive than cytology testing. ScienceDaily. Retrieved September 20, 2014 from www.sciencedaily.com/releases/2010/07/100708111330.htm
Queen Mary, University of London. "HPV DNA testing over 50 percent more sensitive than cytology testing." ScienceDaily. www.sciencedaily.com/releases/2010/07/100708111330.htm (accessed September 20, 2014).

Share This



More Health & Medicine News

Saturday, September 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins