Featured Research

from universities, journals, and other organizations

New links between cholesterol and depression in the elderly

Date:
July 26, 2010
Source:
Elsevier
Summary:
Most people know that high cholesterol levels place them at increased risk for heart disease and stroke. Prior research has shown that particular types of strokes contribute to one’s risk for depression, and that abnormal blood lipid levels can increase the risk of depression in the elderly. However, new findings by French researchers suggest the link between increased cholesterol and depression may be complicated.

Most people know that high cholesterol levels place them at increased risk for heart disease and stroke. Prior research has shown that particular types of strokes contribute to one's risk for depression, and that abnormal blood lipid levels can increase the risk of depression in the elderly.

Related Articles


However, new findings by French researchers, published in Biological Psychiatry, suggest the link between increased cholesterol and depression may be complicated. They evaluated a large population of elderly men and women (aged 65 and over) over a seven year follow-up period, assessing them for symptoms of depression and measuring their lipid levels.

They found that, in women, depression was associated with low levels of the "good" form of cholesterol, high density lipoprotein (HDL). This disturbance in their cholesterol levels put them at higher risk for vascular disease, including stroke, by increasing their risk for developing lesions in their blood vessels called atherosclerotic plaques.

In contrast, the men who were at greater risk of depression had low levels of the "bad" form of cholesterol, low density lipoprotein (LDL). This was especially true for those men with a genetic vulnerability to depression related to a serotonin transporter gene.

This finding in men raises important considerations. Although this pattern of low LDL levels seemingly protects them from developing cardiovascular diseases or strokes, this study suggests that it increases their mental health risk at the same time.

Dr. Marie-Laure Ancelin, corresponding author for this study, commented: "Our results suggest that clinical management of abnormal lipid levels may reduce depression in the elderly, but different treatment will be required according to sex. LDL-C serum level seems to be an important biological marker in men, with a narrow range for normal functioning. Above this range, cardio- or cerebro-vascular risk increases and below it, there is increased risk of depression."

Therefore, the authors suggest that properly regulating the levels of HDL and LDL may help to prevent depression in the elderly. However, particularly careful management of LDL levels in men seems to be warranted. Dr. John Krystal, Editor of Biological Psychiatry, agreed, noting that "these new data provide yet another important reason that doctors and patients should monitor and regulate cholesterol levels carefully, through a combination of diet and medication."


Story Source:

The above story is based on materials provided by Elsevier. Note: Materials may be edited for content and length.


Journal Reference:

  1. Marie-Laure Ancelin, Isabelle Carri่re, Jean-Philippe Boulenger, Alain Malafosse, Robert Stewart, Jean-Paul Cristol, Karen Ritchie, Isabelle Chaudieu, Anne-Marie Dupuy. Gender and Genotype Modulation of the Association Between Lipid Levels and Depressive Symptomatology in Community-Dwelling Elderly (The ESPRIT Study). Biological Psychiatry, 2010; 68 (2): 125 DOI: 10.1016/j.biopsych.2010.04.011

Cite This Page:

Elsevier. "New links between cholesterol and depression in the elderly." ScienceDaily. ScienceDaily, 26 July 2010. <www.sciencedaily.com/releases/2010/07/100721085448.htm>.
Elsevier. (2010, July 26). New links between cholesterol and depression in the elderly. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2010/07/100721085448.htm
Elsevier. "New links between cholesterol and depression in the elderly." ScienceDaily. www.sciencedaily.com/releases/2010/07/100721085448.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins