Featured Research

from universities, journals, and other organizations

Cancer-metabolism link runs deep in humans, novel network algorithm suggests

Date:
July 23, 2010
Source:
American Institute of Physics
Summary:
Eighty years ago, the medical establishment believed cancer was caused by a dysfunction of metabolism, but the idea went out of vogue. Now, scientists are again looking at metabolism and its role in cancer and other common diseases.

Eighty years ago, the medical establishment believed cancer was caused by a dysfunction of metabolism, but the idea went out of vogue. Now, scientists are again looking at metabolism and its role in cancer and other common diseases. Metabolism is a highly connected network of reactions that are arranged in parallel and interacting pathways. Such parallelism can mask how genes are linked with disease traits and make it difficult to treat conditions.

In a paper in the journal Chaos, published by the American Institute of Physics, researchers at Harvard Medical School and Boston University analyzed ways to "break" the multiple parallel pathways of a metabolic network. The team applied a novel network algorithm to a published genome-scale model of human metabolism to design minimal "knockouts" for a wide variety of metabolic functions, such as phospholipid biosynthesis and the role of fumarase in suppressing human cancer.

The research suggests that the many pathways in the human metabolic network buffer each other to a striking degree, inducing "deep" epistasis -- the suppression of a mutation by one or more seemingly unrelated genes. Their results identify specific in vivo perturbation experiments that could confirm this deep parallelism in human metabolic pathways.

"The results of our analysis could also be used to statistically probe complex relationships between genetic variation and disease," says co-author Marcin Imielinski.


Story Source:

The above story is based on materials provided by American Institute of Physics. Note: Materials may be edited for content and length.


Journal Reference:

  1. Marcin Imielinski, Calin Belta. Deep epistasis in human metabolism. Chaos: An Interdisciplinary Journal of Nonlinear Science, 2010; 20 (2): 026104 DOI: 10.1063/1.3456056

Cite This Page:

American Institute of Physics. "Cancer-metabolism link runs deep in humans, novel network algorithm suggests." ScienceDaily. ScienceDaily, 23 July 2010. <www.sciencedaily.com/releases/2010/07/100721154238.htm>.
American Institute of Physics. (2010, July 23). Cancer-metabolism link runs deep in humans, novel network algorithm suggests. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/2010/07/100721154238.htm
American Institute of Physics. "Cancer-metabolism link runs deep in humans, novel network algorithm suggests." ScienceDaily. www.sciencedaily.com/releases/2010/07/100721154238.htm (accessed April 24, 2014).

Share This



More Health & Medicine News

Thursday, April 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
Study Says Most Crime Not Linked To Mental Illness

Study Says Most Crime Not Linked To Mental Illness

Newsy (Apr. 22, 2014) A new study finds most crimes committed by people with mental illness are not caused by symptoms of their illness or disorder. Video provided by Newsy
Powered by NewsLook.com
Hagel Gets Preview of New High-Tech Projects

Hagel Gets Preview of New High-Tech Projects

AP (Apr. 22, 2014) Defense Secretary Chuck Hagel is given hands-on demonstrations Tuesday of some of the newest research from DARPA _ the military's Defense Advanced Research Projects Agency program. (April 22) Video provided by AP
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins