Featured Research

from universities, journals, and other organizations

Childhood cancer survivors may have abnormal long-term cardiac function

Date:
July 26, 2010
Source:
JAMA and Archives Journals
Summary:
Childhood cancer survival is associated with increased risk of long-term abnormalities in cardiac function, according to a new study.

Childhood cancer survival is associated with increased risk of long-term abnormalities in cardiac function, according to a report in the July 26 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

Related Articles


According to background in the article, childhood cancer survival rates have improved from 20 percent in the 1940s to roughly 70 to 80 percent currently. The authors also note that, "unfortunately, improved survival is accompanied by the occurrence of late treatment effects. Cardiovascular disease and cardiac mortality are among the most serious late effects." Additionally, the authors acknowledge, "several population-based studies observed a six- to eight-fold increased mortality owing to cardiovascular disease among childhood cancer survivors compared with the general population."

Helena J. van der Pal, M.D., from the Emma Children's Hospital/Academic Medical Center, Amsterdam, the Netherlands, and colleagues studied 601 childhood cancer survivors, surviving five years or more, focusing on previous diagnosis and treatment. The study was designed to "evaluate the prevalence and determinants of left ventricular dysfunction in a large cohort of long-term childhood cancer survivors treated with different potentially cardiotoxic therapies."

The authors found that abnormal cardiac function was observed during long-term follow-up (average duration of follow-up was 15.4 years) in 27 percent of childhood cancer survivors. It was most common in patients who received combined cancer treatments, but the authors found no evidence that sex, high-dose cyclophosphamide or ifosfamide (two cancer treatment drugs) were risk factors for cardiac dysfunction.

'The overall prevalence of 27 percent of childhood cancer survivors with cardiac dysfunction is alarmingly high in the young population," the authors note. "…These patients are expected to be at greater risk of developing clinical heart failure in the future."

"In conclusion, more than 25 percent of young adult childhood cancer survivors had subclinical [early stages, little to no symptoms] cardiac dysfunction at their first visit to the outpatient clinic for late effects of childhood cancer," the authors conclude. "Continued monitoring of all childhood cancer survivors treated with potentially cardiotoxic therapy with or without subclinical cardiac dysfunction is necessary to identify childhood cancer survivors who could possibly benefit from early treatment, which could avoid further deterioration of cardiac function."


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Helena J. van der Pal; Elvira C. van Dalen; Michael Hauptmann; Wouter E. Kok; Huib N. Caron; Cor van den Bos; Foppe Oldenburger; Caro C. Koning; Flora E. van Leeuwen; Leontien C. Kremer. Cardiac Function in 5-Year Survivors of Childhood Cancer: A Long-term Follow-up Study. Arch Intern Med, 2010; 170 (14): 1247-1255 [link]

Cite This Page:

JAMA and Archives Journals. "Childhood cancer survivors may have abnormal long-term cardiac function." ScienceDaily. ScienceDaily, 26 July 2010. <www.sciencedaily.com/releases/2010/07/100726162117.htm>.
JAMA and Archives Journals. (2010, July 26). Childhood cancer survivors may have abnormal long-term cardiac function. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2010/07/100726162117.htm
JAMA and Archives Journals. "Childhood cancer survivors may have abnormal long-term cardiac function." ScienceDaily. www.sciencedaily.com/releases/2010/07/100726162117.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Rural India's Low-Cost Sanitary Pad Revolution

Rural India's Low-Cost Sanitary Pad Revolution

AFP (Nov. 28, 2014) — One man hopes his invention -– a machine that produces cheap sanitary pads –- will help empower Indian women. Duration: 01:51 Video provided by AFP
Powered by NewsLook.com
Research on Bats Could Help Develop Drugs Against Ebola

Research on Bats Could Help Develop Drugs Against Ebola

AFP (Nov. 28, 2014) — In Africa's only biosafety level 4 laboratory, scientists have been carrying out experiments on bats to understand how virus like Ebola are being transmitted, and how some of them resist to it. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
WHO Says Male Ebola Survivors Should Abstain From Sex

WHO Says Male Ebola Survivors Should Abstain From Sex

Newsy (Nov. 28, 2014) — WHO cites four studies that say Ebola can still be detected in semen up to 82 days after the onset of symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins