Featured Research

from universities, journals, and other organizations

Transforming growth factor-βa contributes to kidney disease, study finds

Date:
July 28, 2010
Source:
American Journal of Pathology
Summary:
New research shows that transforming growth factor-beta-a contributes to kidney disease. Chronic kidney disease and end stage renal disease affect more than 2 out of every 1,000 people in the United States. Diabetes and high blood pressure are the two most common causes of chronic kidney disease.

Dr. Wilhelm Kriz and colleagues at the University of Heidelberg, Heidelberg, Germany; the University of Paris, Paris, France; the University of Zurich, Zurich, Switzerland; the University of Berlin, Berlin, Germany; the University of Leipzig, Leipzig, Germany; and the Pennsylvania State University, University Park, Pennsylvania demonstrate that TGF-β1 contributes to kidney disease.

Their report can be found in the August 2010 issue of the American Journal of Pathology.

Chronic kidney disease and end stage renal disease affect more than 2 out of every 1,000 people in the United States. Diabetes and high blood pressure are the two most common causes of chronic kidney disease.

Fibrosis in the kidney is one of the key causes of progressive renal failure. High levels of the inflammatory molecule TGF-β1 in the kidney tubules due to tissue damage can cause fibrosis as well as nephron degeneration, resulting in loss of kidney function. To clarify the mechanisms regulating TGF-β1-mediated renal fibrosis, Koesters et al expressed high levels of TGF-β1 in renal tubules of mice. Nephron degeneration in this system was mediated by decomposition of the tubular cells. These data suggest that TGF-β1 may play a novel role in cell death of renal cells, thus contributing to renal fibrosis.

Dr. Kriz's group "uncover[ed] a novel potential role of TGF-β1, i.e. the induction of autophagy in renal epithelial cells. Its relevance under more usual pathological conditions as a possible further mechanism of programmed cell death remains to be established."


Story Source:

The above story is based on materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Koesters R, Kaissling B, LeHir M, Picard N, Theilig F, Gebhardt R, Glick AB, Hδhnel B, Hosser H, Grφne H-J, Kriz W. Tubular overexpression of transforming growth factor %u03B2 1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells. Am J Pathol, 2010; 177:632-643

Cite This Page:

American Journal of Pathology. "Transforming growth factor-βa contributes to kidney disease, study finds." ScienceDaily. ScienceDaily, 28 July 2010. <www.sciencedaily.com/releases/2010/07/100728120834.htm>.
American Journal of Pathology. (2010, July 28). Transforming growth factor-βa contributes to kidney disease, study finds. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2010/07/100728120834.htm
American Journal of Pathology. "Transforming growth factor-βa contributes to kidney disease, study finds." ScienceDaily. www.sciencedaily.com/releases/2010/07/100728120834.htm (accessed September 17, 2014).

Share This



More Health & Medicine News

Wednesday, September 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) — President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Obama Orders Military Response to Ebola

Obama Orders Military Response to Ebola

AP (Sep. 16, 2014) — Calling the Ebola outbreak in West Africa a potential threat to global security, President Barack Obama is ordering 3,000 U.S. military personnel to the stricken region amid worries that the outbreak is spiraling out of control. (Sept. 16) Video provided by AP
Powered by NewsLook.com
UN: 20,000 Could Be Infected With Ebola by Year End

UN: 20,000 Could Be Infected With Ebola by Year End

AFP (Sep. 16, 2014) — Nearly $1.0 billion dollars is needed to fight the Ebola outbreak raging in west Africa, the United Nations say, warning that 20,000 could be infected by year end. Duration: 00:40 Video provided by AFP
Powered by NewsLook.com
Obama: Ebola Outbreak Threat to Global Security

Obama: Ebola Outbreak Threat to Global Security

AP (Sep. 16, 2014) — President Obama is ordering U.S. military personnel to West Africa to deal with the Ebola outbreak, which is he calls a potential threat to global security. (Sept. 16) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

      Technology News



      Save/Print:
      Share:  

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile iPhone Android Web
      Follow Facebook Twitter Google+
      Subscribe RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins