Featured Research

from universities, journals, and other organizations

New criteria for T-cell lymphoma diagnosis

Date:
July 28, 2010
Source:
American Journal of Pathology
Summary:
Researchers in Italy have discovered new diagnostic criteria to differentiate peripheral T-cell lymphomas (PTCLs).

A group led by Dr. Mario Colombo of the Istituto Nazionale dei Tumori, Milan, Italy and Dr. Stefano Pileri of the Bologna University School of Medicine, Bologna, Italy has discovered new diagnostic criteria to differentiate peripheral T-cell lymphomas (PTCLs).

Related Articles


They present these findings in the August 2010 issue of the American Journal of Pathology.

PTCLs comprise a group of rare and aggressive non-Hodgkin lymphomas that develop from T-cells in different stages of maturity. These diseases have a poor prognosis, with a 5-year survival rate of around 25%.

Subtype differentiation of peripheral T-cell lymphomas, such as autoimmunoblastic T-cell lymphoma (AITL) and peripheral T-cell lymphomas of non-specific origin (PTCL/NOS), is critical for the application of specific therapeutic strategies. Tripodo et al therefore examined the immunological microenvironment of PTCLs to find diagnostic criteria to differentiate AITLs and PTCL/NOS. They found that two types of immune cells, T helper 17 (Th17) cells and mast cells, directly contributed to the pro-inflammatory microenvironment of AITLs but not PTCL/NOS. From their data, they propose that AITL cells may directly recruit mast cells, which then secrete factors that result in the pro-inflammatory, Th17-generating microenvironment that leads to autoimmunity in these patients.

Tipodo and colleagues suggest "the immunological microenvironment of AITL, differently from that of PTCL/NOS, is characterized by the abundance of mast cells likely recruited by CXCL-13, produced, at least in part, by the neoplastic clone of Tfh derivation. In the AITL environment, infiltrating MCs might promote inflammation tipping the balance between immune regulation and autoimmunity and contributing to the local changes occurring in AITL-infiltrated tissues. The possible clinical relevance of microenviromental patterns as well as the potential therapeutic impact of strategies interfering in such dynamics surely warrant further investigation."


Story Source:

The above story is based on materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Tripodo C, Gri G, Piccaluga PP, Frossi B, Guarnotta C, Piconese S, Franco G, Vetri V, Pucillo CE, Florena AM, Colombo MP, Pileri SA. Mast cells and Th17 cells contribute to the lymphoma-associated pro-inflammatory microenvironment of angioimmunoblastic T-cell lymphoma. Am J Pathol, 2010; 177: 792-802

Cite This Page:

American Journal of Pathology. "New criteria for T-cell lymphoma diagnosis." ScienceDaily. ScienceDaily, 28 July 2010. <www.sciencedaily.com/releases/2010/07/100728120910.htm>.
American Journal of Pathology. (2010, July 28). New criteria for T-cell lymphoma diagnosis. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2010/07/100728120910.htm
American Journal of Pathology. "New criteria for T-cell lymphoma diagnosis." ScienceDaily. www.sciencedaily.com/releases/2010/07/100728120910.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins