Featured Research

from universities, journals, and other organizations

New criteria for T-cell lymphoma diagnosis

Date:
July 28, 2010
Source:
American Journal of Pathology
Summary:
Researchers in Italy have discovered new diagnostic criteria to differentiate peripheral T-cell lymphomas (PTCLs).

A group led by Dr. Mario Colombo of the Istituto Nazionale dei Tumori, Milan, Italy and Dr. Stefano Pileri of the Bologna University School of Medicine, Bologna, Italy has discovered new diagnostic criteria to differentiate peripheral T-cell lymphomas (PTCLs).

They present these findings in the August 2010 issue of the American Journal of Pathology.

PTCLs comprise a group of rare and aggressive non-Hodgkin lymphomas that develop from T-cells in different stages of maturity. These diseases have a poor prognosis, with a 5-year survival rate of around 25%.

Subtype differentiation of peripheral T-cell lymphomas, such as autoimmunoblastic T-cell lymphoma (AITL) and peripheral T-cell lymphomas of non-specific origin (PTCL/NOS), is critical for the application of specific therapeutic strategies. Tripodo et al therefore examined the immunological microenvironment of PTCLs to find diagnostic criteria to differentiate AITLs and PTCL/NOS. They found that two types of immune cells, T helper 17 (Th17) cells and mast cells, directly contributed to the pro-inflammatory microenvironment of AITLs but not PTCL/NOS. From their data, they propose that AITL cells may directly recruit mast cells, which then secrete factors that result in the pro-inflammatory, Th17-generating microenvironment that leads to autoimmunity in these patients.

Tipodo and colleagues suggest "the immunological microenvironment of AITL, differently from that of PTCL/NOS, is characterized by the abundance of mast cells likely recruited by CXCL-13, produced, at least in part, by the neoplastic clone of Tfh derivation. In the AITL environment, infiltrating MCs might promote inflammation tipping the balance between immune regulation and autoimmunity and contributing to the local changes occurring in AITL-infiltrated tissues. The possible clinical relevance of microenviromental patterns as well as the potential therapeutic impact of strategies interfering in such dynamics surely warrant further investigation."


Story Source:

The above story is based on materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Tripodo C, Gri G, Piccaluga PP, Frossi B, Guarnotta C, Piconese S, Franco G, Vetri V, Pucillo CE, Florena AM, Colombo MP, Pileri SA. Mast cells and Th17 cells contribute to the lymphoma-associated pro-inflammatory microenvironment of angioimmunoblastic T-cell lymphoma. Am J Pathol, 2010; 177: 792-802

Cite This Page:

American Journal of Pathology. "New criteria for T-cell lymphoma diagnosis." ScienceDaily. ScienceDaily, 28 July 2010. <www.sciencedaily.com/releases/2010/07/100728120910.htm>.
American Journal of Pathology. (2010, July 28). New criteria for T-cell lymphoma diagnosis. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2010/07/100728120910.htm
American Journal of Pathology. "New criteria for T-cell lymphoma diagnosis." ScienceDaily. www.sciencedaily.com/releases/2010/07/100728120910.htm (accessed September 22, 2014).

Share This



More Health & Medicine News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins