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Multiple Sclerosis: Iimmunological study finds earlier way to diagnose axon and neuron degeneration

Date:
July 30, 2010
Source:
University of California - Irvine
Summary:
Immunologists have found that testing for increased levels of antibodies that inhibit energy production in neurons can detect axon and neuron degeneration in multiple sclerosis earlier than existing diagnostic tools.

UCI immunologists have found that testing for increased levels of antibodies that inhibit energy production in neurons can detect multiple sclerosis earlier than existing diagnostic tools.

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The study, led by Yufen Qin, assistant professor of neurology, shows how these inhibitors trigger degeneration of axons and neurons, which results in demyelination, or the breakdown of neurons' protective coating.

Current spinal fluid tests for MS focus on demyelination. Qin says measuring these antibodies, which inhibit an enzyme called GAPDH, could lead to earlier and more effective long-term treatment for MS -- a chronic, often disabling disease that attacks the central nervous system.

The study appears online in The Journal of Immunology.


Story Source:

The above story is based on materials provided by University of California - Irvine. Note: Materials may be edited for content and length.


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University of California - Irvine. "Multiple Sclerosis: Iimmunological study finds earlier way to diagnose axon and neuron degeneration." ScienceDaily. ScienceDaily, 30 July 2010. <www.sciencedaily.com/releases/2010/07/100730091123.htm>.
University of California - Irvine. (2010, July 30). Multiple Sclerosis: Iimmunological study finds earlier way to diagnose axon and neuron degeneration. ScienceDaily. Retrieved March 29, 2015 from www.sciencedaily.com/releases/2010/07/100730091123.htm
University of California - Irvine. "Multiple Sclerosis: Iimmunological study finds earlier way to diagnose axon and neuron degeneration." ScienceDaily. www.sciencedaily.com/releases/2010/07/100730091123.htm (accessed March 29, 2015).

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