Featured Research

from universities, journals, and other organizations

Five new genetic variations linked to prostate cancer uncovered in study on Japanese men

Date:
August 2, 2010
Source:
RIKEN
Summary:
A genome-wide study on Japanese subjects has identified 5 new genetic variations associated with prostate cancer and revealed differences and similarities between Europeans and Asians in susceptibility to the disease. The findings offer a first-ever glimpse of the genetic basis for prostate cancer susceptibility in a non-European population.

A genome-wide study on Japanese subjects has identified 5 new genetic variations associated with prostate cancer and revealed differences and similarities between Europeans and Asians in susceptibility to the disease. Reported in Nature Genetics, the findings offer a first-ever glimpse of the genetic basis for prostate cancer susceptibility in a non-European population.

Despite having the lowest rates of prostate cancer in the world, Asian countries have experienced a rapid rise in incidence of the disease, which ranks as one of the world's most prevalent forms of cancer. In Japan, Western lifestyles and an aging society have led to surging prostate cancer rates, contributing to growing public interest in understanding associated genetic factors. Genome-wide association studies (GWAS), which involve scanning complete genomes for variations linked to a particular disease, have drawn attention as a powerful means to do this.

In their study, researchers at the RIKEN Center for Genomic Medicine (CGM) and the University of Tokyo compared such variations, known as single nucleotide polymorphisms (SNPs), in a population made up of 4,584 Japanese men with prostate cancer and 8,801 control subjects. Out of 31 SNPs linked to prostate cancer susceptibility in previous studies on European subjects, they found that 19 were also associated with susceptibility in the Japanese population. The remaining 12 SNPs showed no association, while five new genomic regions were identified as associated with prostate cancer which had not been reported in early studies on European populations.

While deepening our understanding of the genetic basis of prostate carcinogenesis, these findings, the first ever genome-wide data on prostate cancer in a non-European population, highlight variation in susceptibility among ethnic populations. A better understanding of such variation promises more accurate risk assessment, improvements in screening protocols and more effective clinical treatment.


Story Source:

The above story is based on materials provided by RIKEN. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ryo Takata, Shusuke Akamatsu, Michiaki Kubo, Atsushi Takahashi, Naoya Hosono, Takahisa Kawaguchi, Tatsuhiko Tsunoda, Johji Inazawa, Naoyuki Kamatani, Osamu Ogawa, Tomoaki Fujioka, Yusuke Nakamura and Hidewaki Nakagawa. Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population. Nature Genetics, 2010; DOI: 10.1038/ng.635

Cite This Page:

RIKEN. "Five new genetic variations linked to prostate cancer uncovered in study on Japanese men." ScienceDaily. ScienceDaily, 2 August 2010. <www.sciencedaily.com/releases/2010/08/100802080151.htm>.
RIKEN. (2010, August 2). Five new genetic variations linked to prostate cancer uncovered in study on Japanese men. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2010/08/100802080151.htm
RIKEN. "Five new genetic variations linked to prostate cancer uncovered in study on Japanese men." ScienceDaily. www.sciencedaily.com/releases/2010/08/100802080151.htm (accessed April 20, 2014).

Share This



More Health & Medicine News

Sunday, April 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins