Featured Research

from universities, journals, and other organizations

Heart transplant patients with common disorder have high survival rates

Date:
August 24, 2010
Source:
American Heart Association
Summary:
Short-term survival rates after heart transplant surgery to correct the most common genetic heart disease (hypertrophic cardiomyopathy) are similar to those of patients who received transplants for other heart diseases. Long-term survival rates are higher for hypertrophic cardiomyopathy heart-transplant patients than for other transplant patients.

Transplant surgery to correct the most common type of genetic heart disease yields similar short-term and potentially greater long-term survival rates as transplant surgery for other heart diseases, according to research reported in Circulation: Heart Failure, an American Heart Association journal.

Related Articles


Researchers found similar survival rates one year after heart transplant surgery between hypertrophic cardiomyopathy (HCM) patients (85 percent) and those with other kinds of heart disease (82 percent). Five years post-surgery, survival rates began to diverge with 75 percent of HCM and 70 percent of other patients surviving. At the 10-year mark, survival rates in both groups dropped, although they remained significantly higher in the HCM patients (61 percent) than in those with other heart diseases (49 percent).

"Patients with this disease who are undergoing transplant can expect reasonable long-term survival rates," said Martin S. Maron, M.D., lead author and assistant professor of medicine, director of the Hypertrophic Cardiomyopathy Center, and co-director of Advanced Cardiac Imaging at Tufts Medical Center in Boston, Mass. "That's a crucial clinical message for this small but important subgroup of patients."

Inflammation of the heart muscle (cardiomyopathy) is a serious, potentially fatal disease that can prevent the heart from pumping blood effectively. In HCM -- the second most common form of heart muscle disease -- the pumping chamber of the heart, known as the left ventricle, thickens (hypertrophies), making it stiff and less able to relax and for blood to fill the heart chambers.

Investigators used the United Network of Organ Sharing Registry, a nationwide database of all U.S. transplant patients, to analyze 26,706 adult patients' clinical and survival characteristics. HCM patients comprise about 1 percent of all U.S. heart transplant cases. Yet, the survival rate is comparable to surgeries for other reasons.

Study participants were mostly white (81 percent) and male (79 percent), average age 52. HCM patients, however, tended to be younger, average age 43, and more than half were women. Nearly one-third (31 percent) of participants reported smoking, although this rate was much lower among those with HCM (17 percent). All had received a heart transplant between January 1990 and December 2004.

In the United States, HCM affects about half a million people. Its symptoms vary widely; in some cases they may be mild enough to go unnoticed, while in others they may be severe enough to cause heart failure.

Co-authors are Benjamin M. Kalsmith, M.D.; James E. Udelson, M.D.; Wenjun Li, Ph.D. and David DeNofrio, M.D. Author disclosures are on the manuscript.

Hypertrophic cardiomyopathy (HCM) Facts and Statistics:

HCM is the second most common form of heart muscle disease, is usually genetically transmitted, and comprises about 35 to 40% of cardiomyopathies in children.

HCM affects up to 500,000 people in the United States, with children under age 12 accounting for less than 10% of all cases.


Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Journal Reference:

  1. Martin S. Maron, Benjamin M. Kalsmith, James E. Udelson, Wenjun Li, and David Denofrio. Survival Following Cardiac Transplantation in Patients with Hypertrophic Cardiomyopathy. Circ Heart Fail, Aug 24, 2010 DOI: 10.1161/CIRCHEARTFAILURE.109.922872

Cite This Page:

American Heart Association. "Heart transplant patients with common disorder have high survival rates." ScienceDaily. ScienceDaily, 24 August 2010. <www.sciencedaily.com/releases/2010/08/100824161507.htm>.
American Heart Association. (2010, August 24). Heart transplant patients with common disorder have high survival rates. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2010/08/100824161507.htm
American Heart Association. "Heart transplant patients with common disorder have high survival rates." ScienceDaily. www.sciencedaily.com/releases/2010/08/100824161507.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Nurse Nina Pham Cured of Ebola

Texas Nurse Nina Pham Cured of Ebola

AFP (Oct. 25, 2014) — An American nurse who contracted Ebola while caring for a Liberian patient in Texas has been declared free of the virus and will leave the hospital. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) — The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins