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Heart transplant patients with common disorder have high survival rates

August 24, 2010
American Heart Association
Short-term survival rates after heart transplant surgery to correct the most common genetic heart disease (hypertrophic cardiomyopathy) are similar to those of patients who received transplants for other heart diseases. Long-term survival rates are higher for hypertrophic cardiomyopathy heart-transplant patients than for other transplant patients.

Transplant surgery to correct the most common type of genetic heart disease yields similar short-term and potentially greater long-term survival rates as transplant surgery for other heart diseases, according to research reported in Circulation: Heart Failure, an American Heart Association journal.

Researchers found similar survival rates one year after heart transplant surgery between hypertrophic cardiomyopathy (HCM) patients (85 percent) and those with other kinds of heart disease (82 percent). Five years post-surgery, survival rates began to diverge with 75 percent of HCM and 70 percent of other patients surviving. At the 10-year mark, survival rates in both groups dropped, although they remained significantly higher in the HCM patients (61 percent) than in those with other heart diseases (49 percent).

"Patients with this disease who are undergoing transplant can expect reasonable long-term survival rates," said Martin S. Maron, M.D., lead author and assistant professor of medicine, director of the Hypertrophic Cardiomyopathy Center, and co-director of Advanced Cardiac Imaging at Tufts Medical Center in Boston, Mass. "That's a crucial clinical message for this small but important subgroup of patients."

Inflammation of the heart muscle (cardiomyopathy) is a serious, potentially fatal disease that can prevent the heart from pumping blood effectively. In HCM -- the second most common form of heart muscle disease -- the pumping chamber of the heart, known as the left ventricle, thickens (hypertrophies), making it stiff and less able to relax and for blood to fill the heart chambers.

Investigators used the United Network of Organ Sharing Registry, a nationwide database of all U.S. transplant patients, to analyze 26,706 adult patients' clinical and survival characteristics. HCM patients comprise about 1 percent of all U.S. heart transplant cases. Yet, the survival rate is comparable to surgeries for other reasons.

Study participants were mostly white (81 percent) and male (79 percent), average age 52. HCM patients, however, tended to be younger, average age 43, and more than half were women. Nearly one-third (31 percent) of participants reported smoking, although this rate was much lower among those with HCM (17 percent). All had received a heart transplant between January 1990 and December 2004.

In the United States, HCM affects about half a million people. Its symptoms vary widely; in some cases they may be mild enough to go unnoticed, while in others they may be severe enough to cause heart failure.

Co-authors are Benjamin M. Kalsmith, M.D.; James E. Udelson, M.D.; Wenjun Li, Ph.D. and David DeNofrio, M.D. Author disclosures are on the manuscript.

Hypertrophic cardiomyopathy (HCM) Facts and Statistics:

HCM is the second most common form of heart muscle disease, is usually genetically transmitted, and comprises about 35 to 40% of cardiomyopathies in children.

HCM affects up to 500,000 people in the United States, with children under age 12 accounting for less than 10% of all cases.

Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.

Journal Reference:

  1. Martin S. Maron, Benjamin M. Kalsmith, James E. Udelson, Wenjun Li, and David Denofrio. Survival Following Cardiac Transplantation in Patients with Hypertrophic Cardiomyopathy. Circ Heart Fail, Aug 24, 2010 DOI: 10.1161/CIRCHEARTFAILURE.109.922872

Cite This Page:

American Heart Association. "Heart transplant patients with common disorder have high survival rates." ScienceDaily. ScienceDaily, 24 August 2010. <www.sciencedaily.com/releases/2010/08/100824161507.htm>.
American Heart Association. (2010, August 24). Heart transplant patients with common disorder have high survival rates. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/2010/08/100824161507.htm
American Heart Association. "Heart transplant patients with common disorder have high survival rates." ScienceDaily. www.sciencedaily.com/releases/2010/08/100824161507.htm (accessed October 2, 2014).

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