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'Toolbox of MiniPromoters' for gene research and therapy created

Date:
August 30, 2010
Source:
University of British Columbia
Summary:
Researchers have developed a new "toolbox of MiniPromoters" for research and future therapies on brain, spinal cord and eye function.

University of British Columbia researchers have led the development of a new "toolbox of MiniPromoters" for research and future therapies on brain, spinal cord and eye function.

MiniPromoters are small segments of human DNA with the ability to turn genes on and off at specific times and locations. They're important tools used by scientists and clinicians to mark cells, explore function and deliver therapeutic genetic medicine. Gene therapy, or targeted gene replacement, is being investigated as potential therapy for neurodegenerative disorders such as Alzheimer Disease, Parkinson Disease, Huntington Disease, Multiple Sclerosis, Aniridia and cancer.

Led by Elizabeth M. Simpson, UBC Medical Genetics Professor and Senior Scientist at the Centre for Molecular Medicine and Therapeutics at the Child & Family Research Institute, an international team of 64 researchers are making available 27 new MiniPromoters, greatly expanding the current limited pool of these vital tools for research and treatment of these disorders.

Using genome analysis, the research team identified new regions of human DNA that can activate a gene in certain brain regions but not others. Further research will focus on refining the gene expression patterns and optimizing gene delivery methods in animal models.

Details of the project, called the Genome Canada Pleiades Promoter Project, are scheduled to be published online in PNAS Early Edition this week.

The study's co-authors come from UBC, the Centre for Molecular Medicine and Therapeutics at the Child & Family Research Institute, the Michael Smith Genome Sciences Centre at BC Cancer Agency, Simon Fraser University and the University of Tennessee. The study was funded by Genome Canada, Genome British Columbia, GlaxoSmithKline R&D Ltd., BC Mental Health and Addiction Services, Child & Family Research Institute, and the UBC Institute of Mental Health.


Story Source:

The above story is based on materials provided by University of British Columbia. Note: Materials may be edited for content and length.


Cite This Page:

University of British Columbia. "'Toolbox of MiniPromoters' for gene research and therapy created." ScienceDaily. ScienceDaily, 30 August 2010. <www.sciencedaily.com/releases/2010/08/100830152602.htm>.
University of British Columbia. (2010, August 30). 'Toolbox of MiniPromoters' for gene research and therapy created. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2010/08/100830152602.htm
University of British Columbia. "'Toolbox of MiniPromoters' for gene research and therapy created." ScienceDaily. www.sciencedaily.com/releases/2010/08/100830152602.htm (accessed September 2, 2014).

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