Featured Research

from universities, journals, and other organizations

Computer models suggest treatments for fractures that won't heal

Date:
September 11, 2010
Source:
Public Library of Science
Summary:
New models, reinforced by in vivo experimentation, show why 5-10 percent of bone fractures don't heal properly, and how these cases may be treated to restart the healing process. Results of the model may benefit the aging population in which the occurrence of bone fractures is expected to rise substantially in the near future.

New models, reinforced by in vivo experimentation, show why 5-10% of bone fractures don't heal properly, and how these cases may be treated to restart the healing process. Results of the model, published September 2 in the open-access journal PLoS Computational Biology, may benefit the aging population in which the occurrence of bone fractures is expected to rise substantially in the near future.

Related Articles


In 5 to 10% of bone fracture cases, the healing process does not succeed in repairing the bone, which leads to the formation of delayed unions or even non-unions -- fractures that fail to heal. Using a combination of an animal model mimicking a clinical non-union situation and a mathematical model developed for studying normal fracture healing, researchers at the Katholieke Universiteit Leuven (Belgium), University of Liθge (Belgium), Edinburgh University (United Kingdom) and Oxford University (United Kingdom) investigated this health problem.

For example, the authors investigated the potential to treat non-unions by transplanting cells from the bone marrow to the fracture site. This was also tested in a pilot animal experiment; both the simulations and the experiments showed the formation of a bony union between the fractured bone ends. In addition, the researchers used the mathematical model to explain some unexpected experimental observations.

The study demonstrates the added value of using a combination of mathematical modelling and experimental research, as well the potential of using cell transplantation for the treatment of non-unions.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Geris L, Reed AAC, Vander Sloten J, Simpson AHRW, Van Oosterwyck H. Occurrence and Treatment of Bone Atrophic Non-Unions Investigated by an Integrative Approach. PLoS Computational Biology, 2010; 6(9): e1000915 DOI: 10.1371/journal.pcbi.1000915

Cite This Page:

Public Library of Science. "Computer models suggest treatments for fractures that won't heal." ScienceDaily. ScienceDaily, 11 September 2010. <www.sciencedaily.com/releases/2010/09/100902173255.htm>.
Public Library of Science. (2010, September 11). Computer models suggest treatments for fractures that won't heal. ScienceDaily. Retrieved October 31, 2014 from www.sciencedaily.com/releases/2010/09/100902173255.htm
Public Library of Science. "Computer models suggest treatments for fractures that won't heal." ScienceDaily. www.sciencedaily.com/releases/2010/09/100902173255.htm (accessed October 31, 2014).

Share This



More Health & Medicine News

Friday, October 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

U.S. Ebola Response Measures Demonstrated

U.S. Ebola Response Measures Demonstrated

AP (Oct. 31, 2014) — Officials in the Washington area showed off Ebola response measures being taken at Dulles International Airport and the National Institutes of Health. (Oct. 31) Video provided by AP
Powered by NewsLook.com
Fauci Says Ebola Risk in US "essentially Zero"

Fauci Says Ebola Risk in US "essentially Zero"

AP (Oct. 30, 2014) — NIAID Director Anthony Fauci said the risk of Ebola becoming an epidemic in the U.S. is essentially zero Thursday at the Washington Ideas Forum. He also said an Ebola vaccine will be tested in West Africa in the next few months. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Nurse Defies Ebola Quarantine With Bike Ride

Nurse Defies Ebola Quarantine With Bike Ride

AP (Oct. 30, 2014) — A nurse who vowed to defy Maine's voluntary quarantine for health care workers who treated Ebola patients followed through on her promise Thursday, leaving her home for an hour-long bike ride. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Pot-Infused Edibles Raise Concerns in Colorado

Pot-Infused Edibles Raise Concerns in Colorado

AFP (Oct. 30, 2014) — Colorado may have legalized marijuana for recreational use, but the debate around the decision still continues, with a recent - failed - attempt to ban cannabis-infused edibles. Duration: 01:53 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins