Featured Research

from universities, journals, and other organizations

Frog skin may provide antimicrobial peptides effective against multidrug-resistant infections

Date:
September 10, 2010
Source:
American Society for Microbiology
Summary:
Antimicrobial peptides from the skin of frogs may protect against life-threatening, multidrug-resistant infections such as Pseudomonas aeruginosa, say researchers from Italy.

Antimicrobial peptides from the skin of frogs may protect against life-threatening, multidrug-resistant infections such as Pseudomonas aeruginosa, say researchers from Italy.

They detail their findings in the September 2010 issue of the journal Antimicrobial Agents and Chemotherapy.

P. aeruginosa is an opportunistic pathogen that causes some of the most prevalent life-threatening infections such as eye and ear infections, burn wound infections and lung infections in cystic fibrosis patients. Strains of the bacterium resistant to almost all antibiotics have already emerged causing researchers to seek new drug therapies.

"Unlike other organisms, P. aeruginosa is a pathogen endowed with high intrinsic drug resistance, due in part to many elaborate virulence factors and the formation of a biofilm matrix, which makes it difficult for antibiotics and immune cells to attack," say the researchers.

Membrane-active cationic antimicrobial peptides (CAMPs) are a new class of antibiotics produced by almost all forms of life, however, amphibian skin is one of the richest sources. Although prior studies have shown that these peptides possess potent antimicrobial activity against multidrug-resistant pathogens in a controlled environment, little is known of their effects within a living organism.

Researchers evaluated the antimicrobial activities of different CAMPs from frog skin using the worm model, Caenorhabditis elegans, in which bacterial species such as P. aeruginosa can pass through the mouth, invade the gut and ultimately kill the animal. The process by which the bacterium infects and kills C. elegans is comparable to the infection process in mammals making it an ideal model for observation. Results showed that all of the peptides studied, with the exception of one, increased the survival rate of P. aeruginosa-infected worms compared with those not receiving peptide treatments.

"Besides shedding light on a plausible mode of action in vivo of amphibian CAMPs, our data suggest that esculentin and temporin peptides can serve as attractive molecules for the development of new therapeutic strategies to fight life-threatening infectious diseases," say the researchers.


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Journal Reference:

  1. D. Uccelletti, E. Zanni, L. Marcellini, C. Palleschi, D. Barra, M. L. Mangoni. Anti-Pseudomonas Activity of Frog Skin Antimicrobial Peptides in a Caenorhabditis elegans Infection Model: a Plausible Mode of Action In Vitro and In Vivo. Antimicrobial Agents and Chemotherapy, 2010; 54 (9): 3853 DOI: 10.1128/AAC.00154-10

Cite This Page:

American Society for Microbiology. "Frog skin may provide antimicrobial peptides effective against multidrug-resistant infections." ScienceDaily. ScienceDaily, 10 September 2010. <www.sciencedaily.com/releases/2010/09/100908104310.htm>.
American Society for Microbiology. (2010, September 10). Frog skin may provide antimicrobial peptides effective against multidrug-resistant infections. ScienceDaily. Retrieved August 30, 2014 from www.sciencedaily.com/releases/2010/09/100908104310.htm
American Society for Microbiology. "Frog skin may provide antimicrobial peptides effective against multidrug-resistant infections." ScienceDaily. www.sciencedaily.com/releases/2010/09/100908104310.htm (accessed August 30, 2014).

Share This




More Health & Medicine News

Saturday, August 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

3 Things To Know About The Ebola Outbreak's Progression

3 Things To Know About The Ebola Outbreak's Progression

Newsy (Aug. 29, 2014) Here are three things you need to know about the deadly Ebola outbreak's progression this week. Video provided by Newsy
Powered by NewsLook.com
Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Who Could Be Burnt by WHO's E-Cigs Move?

Who Could Be Burnt by WHO's E-Cigs Move?

Reuters - Business Video Online (Aug. 28, 2014) The World Health Organisation has called for the regulation of electronic cigarettes as both tobacco and medical products. Ciara Lee looks at the impact of the move on the tobacco industry. Video provided by Reuters
Powered by NewsLook.com
CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

Newsy (Aug. 28, 2014) CDC director Tom Frieden says the Ebola outbreak is even worse than he feared. But he also said there's still hope to contain it. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins