Featured Research

from universities, journals, and other organizations

Key molecule for keeping other oral microorganisms in check uncovered

Date:
September 26, 2010
Source:
University of Oklahoma
Summary:
A research team has uncovered a key to arresting the growth of thrush -- a type of oral yeast infection that sickens patients with compromised immune systems, diabetes and newborns as well as healthy individuals, who may contract the disease following antibiotic treatment of an illness.

A University of Oklahoma research team has uncovered a key to arresting the growth of thrush -- a type of oral yeast infection that sickens patients with compromised immune systems, diabetes and newborns as well as healthy individuals, who may contract the disease following antibiotic treatment of an illness.

Related Articles


An OU team of natural products chemists and microbiologists observed several clinical strains of Streptococcus mutans capable of arresting the growth of the pathogenic yeast Candida albicans. The bacteria species, S. mutans keeps other oral microorganisms in check by producing a chemical called mutanobactin A, which suppresses the growth of pathogenic microbes before they cause problems for humans.

Further tests are underway to evaluate the use of mutanobactin A as a drug for the treatment of thrush and related Candida infections. This compound may hold the key to understanding how microorganisms live cooperatively inside a human host. Also, these findings could provide clues to how the body's native microflora use naturally-occurring compounds to combat the invasion and spread of potentially pathogenic microbes.

These microbes strike an amazing balance between enhancing human health and causing devastating disease. Chemicals like mutanobactin A will help doctors carefully control microbial pathogens while preserving the integrity of important symbiotic organisms. This could lead to new and better drugs for treating infections and provide antibiotics that are less susceptible to the development of resistance.

Research was performed by Robert H. Cichewicz and P. Matthew Joyner, OU Department of Chemistry and Biochemistry Natural Products Discovery Group; Cichewicz also represents the OU Ecology and Evolutionary Biology Graduate Program; and Felicia Qi, Jinman Liu, Zhijun Zhang and Justin Merritt, OU Health Sciences Center College of Dentistry.

Ultimately, the study of microbial chemical communication systems such as mutanobactin A will improve the way doctors fight disease and help maintain human well-being. Findings from this study were published in the online edition of the September 17 issue of the journal Organic and Biomolecular Chemistry.


Story Source:

The above story is based on materials provided by University of Oklahoma. Note: Materials may be edited for content and length.


Journal Reference:

  1. P. Matthew Joyner, Jinman Liu, Zhijun Zhang, Justin Merritt, Fengxia Qi, Robert H. Cichewicz. Mutanobactin A from the human oral pathogen Streptococcus mutans is a cross-kingdom regulator of the yeast-mycelium transition. Organic & Biomolecular Chemistry, 2010; DOI: 10.1039/C0OB00579G

Cite This Page:

University of Oklahoma. "Key molecule for keeping other oral microorganisms in check uncovered." ScienceDaily. ScienceDaily, 26 September 2010. <www.sciencedaily.com/releases/2010/09/100924095826.htm>.
University of Oklahoma. (2010, September 26). Key molecule for keeping other oral microorganisms in check uncovered. ScienceDaily. Retrieved February 1, 2015 from www.sciencedaily.com/releases/2010/09/100924095826.htm
University of Oklahoma. "Key molecule for keeping other oral microorganisms in check uncovered." ScienceDaily. www.sciencedaily.com/releases/2010/09/100924095826.htm (accessed February 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, February 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Obama To Outline New Plan For Personalized Medicine

Obama To Outline New Plan For Personalized Medicine

Newsy (Jan. 30, 2015) President Obama is expected to speak with drugmakers Friday about his Precision Medicine Initiative first introduced last week. Video provided by Newsy
Powered by NewsLook.com
NFL Concussions Down; Still on Parents' Minds

NFL Concussions Down; Still on Parents' Minds

AP (Jan. 30, 2015) The NFL announced this week that the number of game concussions dropped by a quarter over last season. Still, the dangers of the sport still weigh on players, and parents&apos; minds. (Jan. 30) Video provided by AP
Powered by NewsLook.com
U.S. Wants to Analyze DNA from 1 Million People

U.S. Wants to Analyze DNA from 1 Million People

Reuters - US Online Video (Jan. 30, 2015) The U.S. has proposed analyzing genetic information from more than 1 million American volunteers to learn how genetic variants affect health and disease. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins