Featured Research

from universities, journals, and other organizations

LIM kinase plays a key role in cancer metastasis

Date:
September 27, 2010
Source:
Rockefeller University Press
Summary:
Researchers have shown that LIM kinase, or LIMK, an important regulator of actin cytoskeleton dynamics, plays a key role in cancer metastasis.

Researchers have shown that LIM kinase (LIMK), an important regulator of actin cytoskeleton dynamics, plays a key role in cancer metastasis. The study appears online on September 27 in The Journal of Cell Biology.

Related Articles


Cancer metastasis is a multi-stage process that starts with the invasion of tumor cells into their surrounding tissue. The ability of metastatic cells to invade requires reorganization of the actin-myosin cytoskeleton, which is controlled by a sophisticated network of signals sent between a number of cellular components.

LIMK has been shown previously to facilitate tumor invasion through its role in actin regulation. Researchers from the United Kingdom delved deeper into the role of LIMK in this process. The team showed that LIMK is specifically required for cells at the front of the invading tumor to clear a path that the remaining metastatic cells can follow. Working with breast cancer and squamous carcinoma cells, the team found that inhibiting LIMK function blocked the collective invasion of tumor cells, thus preventing these cells from metastasizing.

The authors propose that LIMK inhibitors might be effective in the treatment of cancers such as prostate cancer, where the presence of localized tumors might not be life threatening but mortality can result from metastasis.


Story Source:

The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. R. W. Scott, S. Hooper, D. Crighton, A. Li, I. Konig, J. Munro, E. Trivier, G. Wickman, P. Morin, D. R. Croft, J. Dawson, L. Machesky, K. I. Anderson, E. A. Sahai, M. F. Olson. LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells. The Journal of Cell Biology, 2010; 191 (1): 169 DOI: 10.1083/jcb.201002041

Cite This Page:

Rockefeller University Press. "LIM kinase plays a key role in cancer metastasis." ScienceDaily. ScienceDaily, 27 September 2010. <www.sciencedaily.com/releases/2010/09/100927122219.htm>.
Rockefeller University Press. (2010, September 27). LIM kinase plays a key role in cancer metastasis. ScienceDaily. Retrieved November 24, 2014 from www.sciencedaily.com/releases/2010/09/100927122219.htm
Rockefeller University Press. "LIM kinase plays a key role in cancer metastasis." ScienceDaily. www.sciencedaily.com/releases/2010/09/100927122219.htm (accessed November 24, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, November 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Winter Can Cause Depression — Here's How To Combat It

Winter Can Cause Depression — Here's How To Combat It

Newsy (Nov. 23, 2014) Millions of American suffer from seasonal depression every year. It can lead to adverse health effects, but there are ways to ease symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
Don't Fall For Flu Shot Myths

Don't Fall For Flu Shot Myths

Newsy (Nov. 23, 2014) Misconceptions abound when it comes to your annual flu shot. Medical experts say most people older than 6 months should get the shot. Video provided by Newsy
Powered by NewsLook.com
WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins