Featured Research

from universities, journals, and other organizations

Cost-effectiveness of routine use of pooled nucleic acid amplification testing

Date:
September 28, 2010
Source:
Public Library of Science
Summary:
Detection of acute HIV infection (the stage of disease immediately after HIV acquisition but before HIV antibodies are detectable) with pooled nucleic acid amplification testing (that detects the presence of HIV genetic material in the blood before antibodies are detectable) is feasible but not cost-effective in all settings, according to new research.

Detection of acute HIV infection (the stage of disease immediately after HIV acquisition but before HIV antibodies are detectable) with pooled nucleic acid amplification testing (that detects the presence of HIV genetic material in the blood before antibodies are detectable) is feasible but not cost-effective in all settings, according to new research. Rather, pooled nucleic acid amplification testing after testing for antibodies with third-generation enzyme immunoassays (which can detect the first antibody to appear after infection) or rapid testing is only cost-effective when targeted to settings with very high HIV incidence, such as clinics that serve men who have sex with men (MSM).

Related Articles


These are the findings of a study by Angela Hutchinson from the Centers for Disease Control and Prevention, Atlanta, Georgia, USA, and colleagues published in this week's PLoS Medicine.

The authors combined effectiveness data from a clinical trial of pooled nucleic acid amplification testing in three settings in the USA (sexually transmitted disease clinics, a community clinic serving MSM and HIV counseling/testing sites) with a "micro-costing" study of pooled nucleic acid amplification testing and a mathematical model of HIV transmission. They then calculated the costs per quality-adjusted life year (QALY) gained (the cost-effectiveness ratio) by identifying and notifying people with acute HIV infection through screening using pooled nucleic acid amplification testing compared with repeat antibody testing at different intervals, including annual testing (the recommended testing interval for high-risk individuals).

The authors estimated that each QALY gained from pooled nucleic acid amplification testing following annual antibody testing would cost US$372,300 and US$484,400 for the counseling/testing sites and sexually transmitted disease clinics, respectively, a result which is generally considered to be not cost effective. However, this method was cost-saving for the clinic that served MSM. The cost-effectiveness ratio increased for the counseling/testing sites and sexually transmitted disease clinics when the antibody testing interval was decreased to 6 months but remained cost-saving for the clinic that served MSM. However, with an antibody testing interval of 5 years, pooled nucleic acid amplification testing was cost-saving in all three settings. Yet the authors noted that most of the benefits that made it cost-effective during the 5-year interval between retesting occurred long after the acute phase, when antibody testing could have been repeated.

The authors conclude, "Pooled screening [nucleic acid amplification testing] for [acute HIV infection] following negative third-generation antibody or rapid tests is not cost-effective at recommended antibody testing intervals for high-risk persons except [for those] in very high-incidence settings."


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Hutchinson AB, Patel P, Sansom SL, Farnham PG, Sullivan TJ, et al. Cost-Effectiveness of Pooled Nucleic Acid Amplification Testing for Acute HIV Infection after Third-Generation HIV Antibody Screening and Rapid Testing in the United States: A Comparison of Three Public Health Settings. PLoS Medicine, 2010; 7 (9): e1000342 DOI: 10.1371/journal.pmed.1000342

Cite This Page:

Public Library of Science. "Cost-effectiveness of routine use of pooled nucleic acid amplification testing." ScienceDaily. ScienceDaily, 28 September 2010. <www.sciencedaily.com/releases/2010/09/100928171424.htm>.
Public Library of Science. (2010, September 28). Cost-effectiveness of routine use of pooled nucleic acid amplification testing. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2010/09/100928171424.htm
Public Library of Science. "Cost-effectiveness of routine use of pooled nucleic acid amplification testing." ScienceDaily. www.sciencedaily.com/releases/2010/09/100928171424.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins