Featured Research

from universities, journals, and other organizations

Swine flu patients benefited from taking Tamiflu, says study

Date:
September 30, 2010
Source:
BMJ-British Medical Journal
Summary:
Healthy people who caught swine flu during the 2009 pandemic may have been protected against developing radiographically (X-ray) confirmed pneumonia by taking the antiviral drug oseltamivir (Tamiflu), concludes a study of cases in China.

Healthy people who caught swine flu during the 2009 pandemic may have been protected against developing radiographically (x-ray) confirmed pneumonia by taking the antiviral drug oseltamivir (Tamiflu), concludes a study of cases in China published online in the British Medical Journal.

Related Articles


The researchers also show that oseltamivir treatment was associated with shorter duration of fever and viral RNA shedding (the period when a virus is contagious), although they stress that their findings should be interpreted with caution.

In 2009, pandemic influenza A (H1N1) virus spread rapidly, resulting in millions of cases and over 18,000 deaths in over 200 countries.

Trials carried out on seasonal flu viruses have shown that taking antiviral drugs within 48 hours of symptom onset can reduce the severity and duration of symptoms, and possibly the risk of complications.

However, the extent to which antivirals may benefit otherwise healthy individuals with mild 2009 H1N1 infection, remains unknown.

So researchers reviewed the medical records of 1,291 patients in China with laboratory confirmed mild H1N1 infection during the 2009 pandemic.

The average age of patients was 20 years. Three quarters (76%) were treated with oseltamivir from a median of the third day of symptoms. Of 920 patients who had a chest x-ray, a minority (12%) had abnormal findings consistent with pneumonia.

No patients required intensive care unit admission or mechanical ventilation.

Using statistical modelling of the patients' data, the researchers ruled out the effects of age, sex, influenza vaccination, and treatment with antibiotics on the main study outcomes: getting pneumonia, having prolonged high fever, and viral RNA shedding. Oseltamivir treatment was then identified as a significant protective factor against subsequent development of pneumonia, confirmed by a chest x-ray. This protective effect was seen in all patients including those who started treatment more than two days after onset of symptoms.

Oseltamivir treatment started within two days of symptom onset also reduced the duration of fever and viral RNA shedding, they add. They also found that 2009 H1N1 might be shed longer than seasonal influenza virus.

These findings are consistent with patients with the 2009 H1N1 benefiting from use of oseltamivir, conclude the authors. However, they stress that their finding that oseltamivir treatment protected against subsequent radiographic pneumonia should be interpreted with caution, given the retrospective design of this work and the fact that not all patients underwent a chest x-ray.

They call for continued investigation into the effectiveness of antiviral treatment "to allow for improvement both in clinical treatment and public health guidance."


Story Source:

The above story is based on materials provided by BMJ-British Medical Journal. Note: Materials may be edited for content and length.


Journal Reference:

  1. H. Yu, Q. Liao, Y. Yuan, L. Zhou, N. Xiang, Y. Huai, X. Guo, Y. Zheng, H. R. van Doorn, J. Farrar, Z. Gao, Z. Feng, Y. Wang, W. Yang. Effectiveness of oseltamivir on disease progression and viral RNA shedding in patients with mild pandemic 2009 influenza A H1N1: opportunistic retrospective study of medical charts in China. BMJ, 2010; 341 (sep28 1): c4779 DOI: 10.1136/bmj.c4779

Cite This Page:

BMJ-British Medical Journal. "Swine flu patients benefited from taking Tamiflu, says study." ScienceDaily. ScienceDaily, 30 September 2010. <www.sciencedaily.com/releases/2010/09/100928193442.htm>.
BMJ-British Medical Journal. (2010, September 30). Swine flu patients benefited from taking Tamiflu, says study. ScienceDaily. Retrieved January 27, 2015 from www.sciencedaily.com/releases/2010/09/100928193442.htm
BMJ-British Medical Journal. "Swine flu patients benefited from taking Tamiflu, says study." ScienceDaily. www.sciencedaily.com/releases/2010/09/100928193442.htm (accessed January 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, January 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Mistakes Should Serve a Lesson Says WHO

Ebola Mistakes Should Serve a Lesson Says WHO

AFP (Jan. 25, 2015) The World Health Organization&apos;s chief on Sunday admitted the UN agency had been caught napping on Ebola, saying it should serve a lesson to avoid similar mistakes in future. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Disneyland Measles Outbreak Spreads To 5 States

Disneyland Measles Outbreak Spreads To 5 States

Newsy (Jan. 24, 2015) Much of the Disneyland measles outbreak is being blamed on the anti-vaccination movement. The CDC encourages just about everyone get immunized. Video provided by Newsy
Powered by NewsLook.com
Growing Measles Outbreak Worries Calif. Parents

Growing Measles Outbreak Worries Calif. Parents

AP (Jan. 23, 2015) Public health officials are rushing to contain a measles outbreak that has sickened 70 people across 6 states and Mexico. The AP&apos;s Raquel Maria Dillon has more. (Jan. 23) Video provided by AP
Powered by NewsLook.com
Smart Wristband to Shock Away Bad Habits

Smart Wristband to Shock Away Bad Habits

Reuters - Innovations Video Online (Jan. 23, 2015) A Boston start-up is developing a wristband they say will help users break bad habits by jolting them with an electric shock. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

    Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins