Featured Research

from universities, journals, and other organizations

Novel test following prostate surgery could detect cancer recurrence earlier

Date:
October 1, 2010
Source:
American Association for Cancer Research
Summary:
A new test could reliably detect early increases in prostate specific antigen levels -- a biomarker commonly used to measure the recurrence of prostate cancer -- in men who have undergone prostate cancer-treating surgery. Earlier detection of these rising levels would allow men with cancer recurrence to undergo earlier, more effective treatment for potentially better outcomes.

A new test could reliably detect early increases in prostate specific antigen (PSA) levels -- a biomarker commonly used to measure the recurrence of prostate cancer -- in men who have undergone prostate cancer-treating surgery. Earlier detection of these rising levels would allow men with cancer recurrence to undergo earlier, more effective treatment for potentially better outcomes.

Related Articles


Data measuring the efficacy of this new test were presented at the Fourth AACR International Conference on Molecular Diagnostics in Cancer Therapeutic Development.

"AccuPSA is a simple blood test that can tell a physician important information about prostate specific antigen levels after radical prostatectomy," said David Wilson, Ph.D., senior director of product development at Quanterix Corporation, the manufacturer of the test. "AccuPSA has the potential to eliminate unnecessary treatments and enable earlier detection of recurrence, which may lead to earlier treatment, better outcomes and have a positive impact on health care costs."

After undergoing radical prostatectomy, many men remain at a significant risk for cancer recurrence. Because of this, patients are monitored very closely for rapid increases in PSA, which may signal cancer recurrence.

Standard PSA tests are primarily used to screen asymptomatic men for prostate cancer. However, once the prostate is surgically removed, PSA levels are usually undetectable using standard tests, according to Wilson. AccuPSA, which uses Quanterix's proprietary Single Molecule Array (SiMoA™) technology, is able to detect PSA with unprecedented sensitivity, and at much lower levels than standard PSA tests because it can selectively capture and measure individual PSA molecules.

To determine the accuracy of the novel blood test, PSA levels were measured in blood taken from 60 men who had undergone radical prostatectomy. These specimens had all been categorized as being below the detection limit of standard PSA tests. However, using AccuPSA, researchers were able to measure PSA in all of the samples.

"After radical prostatectomy, many important questions remain for the physician and the patient," Wilson said. "AccuPSA is designed to help the physician and patients to become better informed by measuring PSA after radical prostatectomy and establishing if the cancer is gone or has metastasized or recurred."

The next step in this research is to conduct a large retrospective clinical study to formally establish the utility of this test.

"We hope to be able to establish with our clinical study that nadir values -- the lowest value of PSA that occurs post-surgery -- are predictive of prostate cancer recurrence," he said. "What this might mean for a post-radical prostatectomy patient is that a nadir PSA level below an established threshold could indicate if the patient is effectively considered 'cured.'"


Story Source:

The above story is based on materials provided by American Association for Cancer Research. Note: Materials may be edited for content and length.


Cite This Page:

American Association for Cancer Research. "Novel test following prostate surgery could detect cancer recurrence earlier." ScienceDaily. ScienceDaily, 1 October 2010. <www.sciencedaily.com/releases/2010/09/100929163407.htm>.
American Association for Cancer Research. (2010, October 1). Novel test following prostate surgery could detect cancer recurrence earlier. ScienceDaily. Retrieved October 31, 2014 from www.sciencedaily.com/releases/2010/09/100929163407.htm
American Association for Cancer Research. "Novel test following prostate surgery could detect cancer recurrence earlier." ScienceDaily. www.sciencedaily.com/releases/2010/09/100929163407.htm (accessed October 31, 2014).

Share This



More Health & Medicine News

Friday, October 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

U.S. Ebola Response Measures Demonstrated

U.S. Ebola Response Measures Demonstrated

AP (Oct. 31, 2014) Officials in the Washington area showed off Ebola response measures being taken at Dulles International Airport and the National Institutes of Health. (Oct. 31) Video provided by AP
Powered by NewsLook.com
Fauci Says Ebola Risk in US "essentially Zero"

Fauci Says Ebola Risk in US "essentially Zero"

AP (Oct. 30, 2014) NIAID Director Anthony Fauci said the risk of Ebola becoming an epidemic in the U.S. is essentially zero Thursday at the Washington Ideas Forum. He also said an Ebola vaccine will be tested in West Africa in the next few months. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Nurse Defies Ebola Quarantine With Bike Ride

Nurse Defies Ebola Quarantine With Bike Ride

AP (Oct. 30, 2014) A nurse who vowed to defy Maine's voluntary quarantine for health care workers who treated Ebola patients followed through on her promise Thursday, leaving her home for an hour-long bike ride. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Pot-Infused Edibles Raise Concerns in Colorado

Pot-Infused Edibles Raise Concerns in Colorado

AFP (Oct. 30, 2014) Colorado may have legalized marijuana for recreational use, but the debate around the decision still continues, with a recent - failed - attempt to ban cannabis-infused edibles. Duration: 01:53 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins