Featured Research

from universities, journals, and other organizations

HPV screen-and treat-intervention effective in cervical cancer prevention

Date:
September 30, 2010
Source:
Journal of the National Cancer Institute
Summary:
Women in South Africa who underwent human papillomavirus DNA-based testing or visual inspection of the cervix followed by treatment of test-positive women with cryotherapy had a statistically significant reduction in high grade cervical cancer precursors, compared with women in a control group, according to a new study.

Women in South Africa who underwent human papillomavirus (HPV) DNA-based testing or visual inspection of the cervix followed by treatment of test-positive women with cryotherapy had a statistically significant reduction in high grade cervical cancer precursors, compared with women in a control group, according to a study published online Sept. 30 in The Journal of the National Cancer Institute.

Related Articles


In many developing countries, especially in sub-Saharan Africa, cytology-based screening is unavailable. To counter this lack of availability, non-cytological screening methods such as DNA testing or visual inspection of the cervix have been developed, methods that do not require the same laboratory infrastructure as cytology and allow for the immediate treatment of women with detected lesions. The approach of screening using non-cytological methods and then treating all test positive women is referred to as "screen-and-treat" and access to such cervical cancer prevention programs may be able to reduce cervical cancer mortality where cytology-based screening is unavailable.

To determine whether HPV DNA-based screening and visual inspection of the cervix reduced cervical cancer, Thomas C. Wright, M.D., of Columbia University, and colleagues, conducted a randomized trial of 6637 unscreened South African women aged 35-56 years, who were assigned to three study arms: HPV DNA screen-and-treat, in which women with a positive HPV test, VIA screen-and-treat in which women with a positive visual inspection test underwent cryotherapy; or a control group, in which further evaluation and treatment were delayed for 6 months. The researchers tested the women for 36 months, and measured cervical cancer lesions of grade two or worse, also known as CIN 2+ for cervical intraepithelial neoplasia.

The researchers found that after 36 months of follow-up, the women who developed CIN2+ included 1.5% in the screen-and-treat arm, 3.8% in the visual inspection-and-treat arm, and 5.6% in the control arm. The authors write, "This study demonstrates that an HPV DNA-based screen-and-treat program for cervical cancer is highly effective and produces a durable reduction in CIN 2+."

Furthermore, they write: "These results suggest that cryotherapy may have long-term implications for low-resource settings where it is difficult and costly to re-screen women at regular intervals."

In an accompanying editorial, Julia C. Gage and Philip E. Castle of the National Cancer Institute write that the advent of accurate low-cost HPV DNA testing bodes well for women in low-income settings -- provided political will and monetary investment accompany technological advancement. "With low-cost accurate HPV screening tests coming online, cervical cancer prevention is becoming more effective, affordable, and feasible for low-resource settings," they write.


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Cite This Page:

Journal of the National Cancer Institute. "HPV screen-and treat-intervention effective in cervical cancer prevention." ScienceDaily. ScienceDaily, 30 September 2010. <www.sciencedaily.com/releases/2010/09/100930161826.htm>.
Journal of the National Cancer Institute. (2010, September 30). HPV screen-and treat-intervention effective in cervical cancer prevention. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/2010/09/100930161826.htm
Journal of the National Cancer Institute. "HPV screen-and treat-intervention effective in cervical cancer prevention." ScienceDaily. www.sciencedaily.com/releases/2010/09/100930161826.htm (accessed March 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Solitair Device Aims to Takes Guesswork out of Sun Safety

Solitair Device Aims to Takes Guesswork out of Sun Safety

Reuters - Innovations Video Online (Mar. 31, 2015) — The Solitair device aims to take the confusion out of how much sunlight we should expose our skin to. Small enough to be worn as a tie or hair clip, it monitors the user&apos;s sun exposure by taking into account their skin pigment, location and schedule. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins