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High response rates seen in phase-III trial of chemotherapy, new drug and stem cells in myeloma

Date:
October 18, 2010
Source:
European Society for Medical Oncology
Summary:
The first study of its kind comparing two different approaches to treating newly diagnosed multiple myeloma has found that both treatments achieved a positive response, researchers say.

The first study of its kind comparing two different approaches to treating newly diagnosed multiple myeloma has found that both treatments achieved a positive response, researchers said at the 35th Congress of the European Society for Medical Oncology (ESMO) in Milan, Italy.

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Dr Antonio Palumbo from Azienda Ospedaliera Universitaria San Giovanni Battista of Torino in Italy and colleagues tested the two approaches for using the drug in a Phase-III trial of 402 patients with newly diagnosed multiple myeloma.

All patients were first administered an induction regimen of the new drug lenalidomide with low-dose dexamethasone. Next they were randomly assigned to one of two consolidation treatments.

The first group of 202 patients received conventional treatment with a combination of melphalan and prednisone, plus lenalidomide. The second group of 200 were given high-dose melphalan plus autologous transplants of their own stem cells.

After the induction treatment, 83% of patients saw a partial response, meaning the level of paraprotein in their blood had dropped by half. Very good partial response (90% reduction in paraprotein) was seen in 34% of patients, and 6% saw a complete response, meaning there was no detectable paraprotein in their blood.

After the consolidation treatment with melphalan, prednisone and lenalidomide, the very good partial response rate was 56%, and the complete response rate was 14%. After high-dose melphalan plus stem cell transplant, very good partial responses were seen 52% of patients, and complete responses in 25%.

"We are actually pleased with these results, since both treatments improved the quality of response achieved with the induction regimen of lenalidomide and dexamethasone," said Dr Palumbo. "However we need a longer follow-up to assess the impact of this finding on both progression-free survival and overall survival."

"This is the first study that compares high-dose chemotherapy with hemopoietic stem-cell support against conventional-dose chemotherapy plus new drugs, and we are pleased to see that with the actual follow-up there was no difference in response between the two arms of the study."

Commented Professor Martin Dreyling, of Munich University Clinic: "Provided that a longer follow-up confirms the preliminary data on progression-free and overall survival, this ground-breaking study will potentially change the standard of care in younger patients with multiple myeloma. Thus, molecular targeted approaches may finally overcome the current approach based on high-dose chemotherapy and subsequent autologous transplantation."


Story Source:

The above story is based on materials provided by European Society for Medical Oncology. Note: Materials may be edited for content and length.


Cite This Page:

European Society for Medical Oncology. "High response rates seen in phase-III trial of chemotherapy, new drug and stem cells in myeloma." ScienceDaily. ScienceDaily, 18 October 2010. <www.sciencedaily.com/releases/2010/10/101012101841.htm>.
European Society for Medical Oncology. (2010, October 18). High response rates seen in phase-III trial of chemotherapy, new drug and stem cells in myeloma. ScienceDaily. Retrieved January 30, 2015 from www.sciencedaily.com/releases/2010/10/101012101841.htm
European Society for Medical Oncology. "High response rates seen in phase-III trial of chemotherapy, new drug and stem cells in myeloma." ScienceDaily. www.sciencedaily.com/releases/2010/10/101012101841.htm (accessed January 30, 2015).

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