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Statin use associated with statistically significant reduction in colorectal cancer

Date:
October 25, 2010
Source:
American College of Gastroenterology
Summary:
A systematic review of the medical literature supports the hypothesis that statins, cholesterol-lowering drugs used to prevent cardiac problems, are associated with reduced risk of colon and rectal cancers. A comprehensive analysis included 22 scientific studies with more than 2.5 million combined participants.

A systematic review of the medical literature supports the hypothesis that statins, cholesterol‐lowering drugs used to prevent cardiac problems, are associated with reduced risk of colon and rectal cancers. A comprehensive analysis by investigators at the University of Michigan at Ann Arbor, included 22 scientific studies with more than 2.5 million combined participants.

"Statin use was associated with a statistically significant reduction in colorectal cancer," explained Jewel Samadder, M.D., MSc. The relative risk was 0.88 (95% CI 0.84‐0.93; n=22) and represents a 12% reduction in the odds of colorectal cancer among statin users. This effect was largely consistent across study design with both case control and cohort studies showing a strong correlation. The length of statin use, both greater than 6 months and greater than 5 years of use was associated with reduction in colorectal cancer risk. Importantly, when the analysis was stratified for statin type, the most common category of statins, lipophilic (which includes atorvastatin or Lipitorฎ), showed the greatest effect.

"Observational studies have suggested that long‐term use of statins is associated with reduced risk of several cancers, including breast, prostate, lung, pancreas and liver. Our findings suggest that randomized controlled trials designed to test the hypothesis that statins reduce the risk of colorectal cancer are warranted," added Dr. Samadder.

The research is being presented at the American College of Gastroenterology's (ACG) 75th Annual Scientific Meeting in San Antonio, Texas.


Story Source:

The above story is based on materials provided by American College of Gastroenterology. Note: Materials may be edited for content and length.


Cite This Page:

American College of Gastroenterology. "Statin use associated with statistically significant reduction in colorectal cancer." ScienceDaily. ScienceDaily, 25 October 2010. <www.sciencedaily.com/releases/2010/10/101018092145.htm>.
American College of Gastroenterology. (2010, October 25). Statin use associated with statistically significant reduction in colorectal cancer. ScienceDaily. Retrieved April 19, 2014 from www.sciencedaily.com/releases/2010/10/101018092145.htm
American College of Gastroenterology. "Statin use associated with statistically significant reduction in colorectal cancer." ScienceDaily. www.sciencedaily.com/releases/2010/10/101018092145.htm (accessed April 19, 2014).

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