Featured Research

from universities, journals, and other organizations

Two-sided immune cell could be harnessed to shrink tumors

Date:
October 28, 2010
Source:
University of Pennsylvania School of Medicine
Summary:
Researchers have found that a protein called inducible costimulator (ICOS) is necessary for the growth and function of human Th17 cells, while CD28, a transmembrane protein on CD4 cells, stops the ICOS signal. What's more, human Th17 stimulated with ICOS shrank human tumors implanted in a mouse model faster than those stimulated with CD28.

Sending the right signals to human Th17 cells to break self-tolerance to tumors. Chrystal Paulos PhD, University of Pennsylvania School of Medicine.
Credit: Image courtesy of University of Pennsylvania School of Medicine

A recently identified immune cell that directs other cells to fight infection plays a critical role in regulating the immune system in both health and disease. Researchers from the University of Pennsylvania School of Medicine have discovered how a stimulatory molecule and a protein found on the membrane of another immune cell make T helper 17 cells multi-taskers of sorts. Th17 cells protect the body against infection and cancer, but are also culprits in some autoimmune diseases and out-of-control, cancerous cell growth.

This new understanding that Th17 cells manage to play both sides of the fence suggests that targeting or inhibiting the involved protein pathways might be a new way to treat cancer, chronic infection, and some autoimmune diseases. Previous studies have linked excessive amounts of Th17 cells in the body to such autoimmune diseases as multiple sclerosis, psoriasis, rheumatoid arthritis, and Crohn's disease.

First author and postdoctoral fellow Chrystal Paulos PhD; senior author Carl June, MD, professor of Pathology and Laboratory Medicine, and colleagues have found that a protein called inducible costimulator (ICOS) is necessary for the growth and function of human Th17 cells, while CD28, a transmembrane protein on CD4 cells, stops the ICOS signal. What's more, human Th17 stimulated with ICOS shrank human tumors implanted in a mouse model faster than those stimulated with CD28. The findings appear in this week's Science Translational Medicine. June is also the Program Director of Translational Research for the Abramson Family Cancer Research Institute at Penn.

These findings were surprising to the researchers given that CD28 has historically been used by investigators to study and expand human Th17 cells. The new data on Th17 cells raises the possibility that the full inflammatory potential of human Th17 cells had not been fully reflected by previous lab studies.

To move this knowledge closer to the clinic, the team also demonstrated that Th17 cells cannot only be expanded to large numbers, but could also be maintained by stimulating them with ICOS proteins. Th17 polarizing cytokines have previously been shown to support Th17 cells from naοve CD4 cells but this is the first demonstration that the ICOS costimulatory molecule used to expand the Th17 cells is important.

Tilting the balance between spurring and suppressing the growth of Th17 cells may be a key to tailoring immunotherapy, a form of cancer treatment. Adoptive transfer of tumor-specific cells expanded with ICOS and polarized to a Th17 cell type might further improve treatment.

These basic findings on Th17 cells in both peripheral and cord blood cells has broad implications, providing the basis of a new human cancer treatment protocol. T-cell-based therapies that incorporate the ICOS signal are being planned at Penn to treat patients with leukemia.

This work was supported by National Cancer Institute.

Other Penn co-authors are Carmine Carpenito, Gabriela Plesa, Megan M. Suhoski, Angel Varela-Rohena, Tatiana N. Golovina, Richard G. Carroll, and James L. Riley.

A patent for the expansion of Th17 cells using ICOS has been filed based on work reported in published article.


Story Source:

The above story is based on materials provided by University of Pennsylvania School of Medicine. Note: Materials may be edited for content and length.


Journal Reference:

  1. C. M. Paulos, C. Carpenito, G. Plesa, M. M. Suhoski, A. Varela-Rohena, T. N. Golovina, R. G. Carroll, J. L. Riley, C. H. June. The Inducible Costimulator (ICOS) Is Critical for the Development of Human TH17 Cells. Science Translational Medicine, 2010; 2 (55): 55ra78 DOI: 10.1126/scitranslmed.3000448

Cite This Page:

University of Pennsylvania School of Medicine. "Two-sided immune cell could be harnessed to shrink tumors." ScienceDaily. ScienceDaily, 28 October 2010. <www.sciencedaily.com/releases/2010/10/101028113616.htm>.
University of Pennsylvania School of Medicine. (2010, October 28). Two-sided immune cell could be harnessed to shrink tumors. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2010/10/101028113616.htm
University of Pennsylvania School of Medicine. "Two-sided immune cell could be harnessed to shrink tumors." ScienceDaily. www.sciencedaily.com/releases/2010/10/101028113616.htm (accessed August 1, 2014).

Share This




More Health & Medicine News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) — The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) — Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) — Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) — Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins