Featured Research

from universities, journals, and other organizations

Prognostic markers for prostate cancer patients who receive radiation after surgery

Date:
November 4, 2010
Source:
Fox Chase Cancer Center
Summary:
Removal of the prostate gland often eradicates early-stage cancer. But patients whose cancer has spread may need to follow up with what is known as salvage radiation therapy. Researchers have now determined a better way to monitor outcomes after this procedure.

Removal of the prostate gland often eradicates early-stage cancer. But patients whose cancer has spread may need to follow up with what is known as salvage radiation therapy. Researchers at Fox Chase have now determined a better way to monitor outcomes after this procedure.

Related Articles


A team led by Mark Buyyounouski, M.D., M.S., radiation oncologist at Fox Chase who will present the results at the annual meeting of the American Society for Radiation Oncology, found that levels of a prostate-specific protein up to 18 months after salvage radiation therapy predict mortality and progression of the disease.

"It's important because if you can identify people who are more likely to die of prostate cancer early, you can talk with them about doing another treatment very quickly, with the hope that it will prolong their lives," says Buyyounouski.

Prostate cancer, the most common cancer in men and the second leading cause of cancer deaths in men, causes nearly 220,000 new cases and more than 30,000 deaths each year. The presence of the disease is indicated by the amount of a protein called prostate-specific antigen (PSA). For men who do not undergo surgery, reaching a PSA level of 2 ng/mL within 18 months after radiation treatment is associated with spread of the disease and higher mortality rates. Buyyounouski and his team were curious about whether the same criterion is important for patients who receive radiation after surgery.

In the study, the scientists looked at 222 patients who went through salvage radiation therapy at Fox Chase between 1991 and 2007. They found that roughly half of the men who surpassed threshold PSA levels in the bloodstream within 18 months after treatment experienced spread of the disease or died within five years. By contrast, men whose PSA levels did not reach the threshold within 18 months did not die within five years, and the likelihood that the disease metastasized was only 17% during that time period. The more quickly the PSA rises, the greater the likelihood the disease will attack other organs and cause death.

"These results provide us with an opportunity to identify patients who should be treated aggressively, before we see any other evidence of prostate cancer," Buyyounouski says. On the other hand, men who approach a PSA level of 2 ng/mL 18 months after treatment or later may not require immediate hormonal therapy, he adds. To confirm the findings, Buyyounouski and his team will next extend the investigation to multiple institutions and a larger set of patients.

Co-authors include Tianyu Li, Aruna Turaka, David Y.T. Chen and Eric M. Horwitz.


Story Source:

The above story is based on materials provided by Fox Chase Cancer Center. Note: Materials may be edited for content and length.


Cite This Page:

Fox Chase Cancer Center. "Prognostic markers for prostate cancer patients who receive radiation after surgery." ScienceDaily. ScienceDaily, 4 November 2010. <www.sciencedaily.com/releases/2010/11/101103095125.htm>.
Fox Chase Cancer Center. (2010, November 4). Prognostic markers for prostate cancer patients who receive radiation after surgery. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2010/11/101103095125.htm
Fox Chase Cancer Center. "Prognostic markers for prostate cancer patients who receive radiation after surgery." ScienceDaily. www.sciencedaily.com/releases/2010/11/101103095125.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins