Featured Research

from universities, journals, and other organizations

Could lung cancer in smokers vs. 'never-smokers' be different diseases?

Date:
November 9, 2010
Source:
American Association for Cancer Research
Summary:
Lung tumors in those who smoke and those who never smoked have different DNA alterations in the tumor genomes, according to results of a pilot study.

Lung tumors in those who smoke and those who never smoked have different DNA alterations in the tumor genomes, according to results of a pilot study presented at the Ninth Annual AACR Frontiers in Cancer Prevention Research Conference, held Nov. 7-10 in Philadelphia.

Based on the results of this study, Kelsie Thu, a Ph.D. candidate at the BC Cancer Research Center in Vancouver, Canada, suggested that "lung cancer in never-smokers should be studied as a separate group," and that lung cancers in smokers and never-smokers may represent two different diseases.

Thu and colleagues investigated the biology of lung cancer to determine how it is different in 30 patients who never smoked vs. 53 patients who were current or former smokers. The goal: to improve the current understanding of lung cancer development.

"A better understanding of the biology underlying lung cancer development will lead to improved detection and therapeutic strategies, and ultimately, will result in improved patient prognosis," she said.

Using genomic technologies, the researchers found regions of DNA that were altered in both the smoker and never-smoker groups, as well as regions of DNA altered preferentially in one group.

Besides having more epidermal growth factor receptor (EGFR) mutations, which is typical, never-smoker tumor genomes had more DNA alterations than smokers altogether. This suggests there may be more genomic instability in never-smoker lung tumors and that they could develop through different molecular mechanisms, according to Thu.

"Hopefully, our findings will stimulate the research community to further investigate the differences between lung cancer in these two cohorts, which could ultimately lead to the discovery of novel molecular targets for the diagnosis and treatment of lung cancer in never-smokers," Thu said.


Story Source:

The above story is based on materials provided by American Association for Cancer Research. Note: Materials may be edited for content and length.


Cite This Page:

American Association for Cancer Research. "Could lung cancer in smokers vs. 'never-smokers' be different diseases?." ScienceDaily. ScienceDaily, 9 November 2010. <www.sciencedaily.com/releases/2010/11/101108190128.htm>.
American Association for Cancer Research. (2010, November 9). Could lung cancer in smokers vs. 'never-smokers' be different diseases?. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2010/11/101108190128.htm
American Association for Cancer Research. "Could lung cancer in smokers vs. 'never-smokers' be different diseases?." ScienceDaily. www.sciencedaily.com/releases/2010/11/101108190128.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Snack Attack: Study Says Action Movies Make You Snack More

Snack Attack: Study Says Action Movies Make You Snack More

Newsy (Sep. 2, 2014) You're more likely to gain weight while watching action flicks than you are watching other types of programming, says a new study published in JAMA. Video provided by Newsy
Powered by NewsLook.com
U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

Newsy (Sep. 2, 2014) The U.N. says the problem is two-fold — quarantine zones and travel restrictions are limiting the movement of both people and food. Video provided by Newsy
Powered by NewsLook.com
Doctors Fear They're Losing Battle Against Ebola

Doctors Fear They're Losing Battle Against Ebola

AP (Sep. 2, 2014) As a third American missionary is confirmed to have contracted Ebola in Liberia, doctors on the ground in West Africa fear they're losing the battle against the outbreak. (Sept. 2) Video provided by AP
Powered by NewsLook.com
Tech Giants Bet on 3D Headsets for Gaming, Healthcare

Tech Giants Bet on 3D Headsets for Gaming, Healthcare

AFP (Sep. 2, 2014) When Facebook acquired the virtual reality hardware developer Oculus VR in March for $2 billion, CEO Mark Zuckerberg hailed the firm's technology as "a new communication platform." Duration: 02:24 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins