Featured Research

from universities, journals, and other organizations

Side effects of hormonal breast cancer therapy increased; may affect treatment adherence

Date:
November 9, 2010
Source:
American Association for Cancer Research
Summary:
Women being treated for breast cancer with aromatase inhibitors may experience extremely low estrogen levels resulting in a wide variety of side effects that a typical postmenopausal woman without cancer may not experience.

Women being treated for breast cancer with aromatase inhibitors may experience extremely low estrogen levels resulting in a wide variety of side effects that a typical postmenopausal woman without cancer may not experience.

Related Articles


Data presented at the Ninth Annual AACR Frontiers in Cancer Prevention Conference, held Nov. 7-10 in Philadelphia, showed that women assigned to take aromatase inhibitors had increases in side effects such as hot flashes, decreased appetite, fatigue, fever, breast sensitivity, etc.

"Aromastase inhibitors represent one of the most major advances in breast cancer treatment," said Lisa Gallicchio, Ph.D., an epidemiologist at The Prevention and Research Center at Mercy Medical Center, Baltimore. "Their incorporation into the breast cancer treatment armamentarium has led to impressive reductions in breast cancer recurrence and mortality rates.

"Despite this, many breast cancer patients stop taking their aromatase inhibitor treatment -- which is usually prescribed for five years -- or do not adhere to their treatment prescription," she said, adding that this may be due to, at least in part, the side effects associated with the drugs.

To better define the full spectrum of side effects associated with aromatase inhibitor treatment, Gallicchio and colleagues surveyed 100 women with breast cancer who were about to start treatment with aromatase inhibitors. Their side effects were compared with those of 200 similarly-aged women without a history of breast cancer.

Questionnaires about symptoms were completed prior to treatment initiation by women with breast cancer and at the start of the study for the healthy women. Women were followed for six months and completed additional questionnaires at three months and at the completion of the study.

Women taking aromatase inhibitors were five times more likely to report having hot flashes, breast sensitivity and chest pain than healthy women. In addition, they were four times more likely to report night sweats, cold sweats and hair loss and about three times more likely to report leg cramps, weight gain, sleep disturbance, tendency to take naps and forgetfulness. Other increased symptoms included intestinal gas, cough, depression, interrupted sleep and irritability.

"We know that aromatase inhibitors are effective in treating breast cancer," Gallicchio said. "Knowing the side effects of aromatase inhibitor treatment and how to treat them is critical for keeping women on their aromatase inhibitor treatment and improving their chances of surviving and living cancer free."


Story Source:

The above story is based on materials provided by American Association for Cancer Research. Note: Materials may be edited for content and length.


Cite This Page:

American Association for Cancer Research. "Side effects of hormonal breast cancer therapy increased; may affect treatment adherence." ScienceDaily. ScienceDaily, 9 November 2010. <www.sciencedaily.com/releases/2010/11/101109133137.htm>.
American Association for Cancer Research. (2010, November 9). Side effects of hormonal breast cancer therapy increased; may affect treatment adherence. ScienceDaily. Retrieved January 28, 2015 from www.sciencedaily.com/releases/2010/11/101109133137.htm
American Association for Cancer Research. "Side effects of hormonal breast cancer therapy increased; may affect treatment adherence." ScienceDaily. www.sciencedaily.com/releases/2010/11/101109133137.htm (accessed January 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, January 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Malnutrition on the Rise as Violence Flares in C. Africa

Malnutrition on the Rise as Violence Flares in C. Africa

AFP (Jan. 28, 2015) Violence can flare up at any moment in Bambari with only a bridge separating Muslims and Christians. Malnutrition is on the rise and lack of water means simple cooking fires threaten to destroy makeshift camps where people are living. Duration: 00:40 Video provided by AFP
Powered by NewsLook.com
Poultry Culled in Taiwan to Thwart Bird Flu

Poultry Culled in Taiwan to Thwart Bird Flu

Reuters - News Video Online (Jan. 28, 2015) Taiwan culls over a million poultry in efforts to halt various strains of avian flu. Julie Noce reports. Video provided by Reuters
Powered by NewsLook.com
Media Criticizing Parents For Not Vaccinating Children

Media Criticizing Parents For Not Vaccinating Children

Newsy (Jan. 28, 2015) As the Disneyland measles outbreak continues to spread, the media says parents who choose not to vaccinate their children are part of the cause. Video provided by Newsy
Powered by NewsLook.com
Shark Bite Victim Making Amazing Recovery

Shark Bite Victim Making Amazing Recovery

AP (Jan. 27, 2015) A Texas woman who lost more than five pounds of flesh to a shark in the Bahamas earlier this month could be released from a Florida hospital soon. Experts believe she was bitten by a bull shark while snorkeling. (Jan. 27) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins