Featured Research

from universities, journals, and other organizations

Rogue gene hijacks stem cells to jumpstart human cancer

Date:
November 10, 2010
Source:
Queen Mary, University of London
Summary:
A gene thought to be responsible for initiating human cancer has been identified by researchers in the UK. The study paves the way for developing early cancer diagnostic tests, and finding new treatments that prevent or stop the spread of cancer cells at an early stage.

A gene thought to be responsible for initiating human cancer has been identified by researchers at Barts and The London School of Medicine and Dentistry. The study -- published online Nov. 9 in the journal Cancer Research -- paves the way for developing early cancer diagnostic tests, and finding new treatments that prevent or stop the spread of cancer cells at an early stage.

Led by Dr Muy-Tek Teh of the Institute of Dentistry at Barts and The London School of Medicine and Dentistry, researchers have shown that a gene called FOXM1 exploits the inherent self-renewal property of stem cells causing excessive cell proliferation. Using adult human stem cells isolated from mouth tissues, the team demonstrated that normal stem cells engineered in the lab to express abnormal levels of FOXM1 gene, triggered excessive cell growth within a 3D tissue culture model system set up to mimic human tissue regeneration in the laboratory. The 3D tissue culture system allows scientists to perform research on manipulated human cells without provoking ethical issues associated with human or animal subjects.

Stem cells expressing normal levels of the FOXM1 gene did not cause excessive cell growth. The abnormal growth triggered by FOXM1 resulted in a condition called hyperplasia -- an early hallmark of pre-cancer. This is thought to represent the very first step of a series of abnormal molecular events leading to cancer formation.

Dr Teh said: "Now we know that FOXM1 plays a key role in cancer initiation we aim to translate our basic findings into clinically useful molecular diagnostic tests to detect cancer growth at early stages. Furthermore, understanding the origin of cancer initiation may unveil new research opportunities for finding effective anti-tumour drugs that stop or prevent cancer at its earliest incipient stage."

The study was co-funded by the Wellcome Trust VIP award, Medical Research Council PhD studentship, the Institute of Dentistry Barts and The London School of Medicine and Dentistry, Queen Mary, University of London and the Norwegian Research Council.


Story Source:

The above story is based on materials provided by Queen Mary, University of London. Note: Materials may be edited for content and length.


Journal Reference:

  1. Emilios Gemenetzidis, Daniela Elena-Costea, Eric K. Parkinson, Ahmad Waseem, Hong Wan, and Muy-Teck Teh. Induction of Human Epithelial Stem/Progenitor Expansion by FOXM1. Cancer Research, 2010; DOI: 10.1158/0008-5472.CAN-10-2173

Cite This Page:

Queen Mary, University of London. "Rogue gene hijacks stem cells to jumpstart human cancer." ScienceDaily. ScienceDaily, 10 November 2010. <www.sciencedaily.com/releases/2010/11/101109133141.htm>.
Queen Mary, University of London. (2010, November 10). Rogue gene hijacks stem cells to jumpstart human cancer. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2010/11/101109133141.htm
Queen Mary, University of London. "Rogue gene hijacks stem cells to jumpstart human cancer." ScienceDaily. www.sciencedaily.com/releases/2010/11/101109133141.htm (accessed October 20, 2014).

Share This



More Health & Medicine News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Microneedle Patch Promises Painless Pricks

Microneedle Patch Promises Painless Pricks

Reuters - Innovations Video Online (Oct. 18, 2014) Researchers at The National University of Singapore have invented a new microneedle patch that could offer a faster and less painful delivery of drugs such as insulin and painkillers. Video provided by Reuters
Powered by NewsLook.com
Raw: Nurse Nina Pham Arrives in Maryland

Raw: Nurse Nina Pham Arrives in Maryland

AP (Oct. 17, 2014) The first nurse to be diagnosed with Ebola at a Dallas hospital walked down the stairs of an executive jet into an ambulance at an airport in Frederick, Maryland, on Thursday. Pham will be treated at the National Institutes of Health. (Oct. 16) Video provided by AP
Powered by NewsLook.com
Raw: Cruise Ship Returns to US Over Ebola Fears

Raw: Cruise Ship Returns to US Over Ebola Fears

AP (Oct. 17, 2014) A Caribbean cruise ship carrying a Dallas health care worker who is being monitored for signs of the Ebola virus is heading back to Texas, US, after being refused permission to dock in Cozumel, Mexico. (Oct. 17) Video provided by AP
Powered by NewsLook.com
Spanish Govt: Four Suspected Ebola Cases in Spain Test Negative

Spanish Govt: Four Suspected Ebola Cases in Spain Test Negative

AFP (Oct. 17, 2014) All four suspected Ebola cases admitted to hospitals in Spain on Thursday have tested negative for the deadly virus in a first round of tests, the government said Friday. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins