Featured Research

from universities, journals, and other organizations

Evidence of link between acetaminophen use in pregnancy and childhood asthma, researchers say

Date:
November 11, 2010
Source:
Queen Mary, University of London
Summary:
Evidence suggesting that the risk of childhood asthma associated with prenatal acetaminophen exposure may depend on antioxidant genes in the mother has been found by a team of UK scientists. The results of their study strengthen the argument for a causal link between acetaminophen exposure in early life and later childhood asthma.

Evidence suggesting that the risk of childhood asthma associated with prenatal exposure to acetaminophen (also known as paracetamol) may depend on antioxidant genes in the mother has been found by a team of UK scientists.

Related Articles


The results of their study, which strengthens the argument for a causal link between acetaminophen exposure in early life and later childhood asthma, are published online Nov. 10 in the Journal of Allergy and Clinical Immunology.

Led by Seif Shaheen, Professor of Respiratory Epidemiology at Barts and The London School of Medicine and Dentistry, the team examined data from the British Avon Longitudinal Study of Parents and Children (ALSPAC) which has followed 14,000 children since birth -- beginning with their mothers' pregnancies and continuing into the children's 8th year. Researchers looked for evidence of interaction between acetaminophen use during pregnancy or infancy and antioxidant genes in the mother or child. Variants in such genes may influence the toxicity of acetaminophen.

Participating mothers reported on their use of acetaminophen during pregnancy, as well as their child's exposure to the drug during infancy. Histories of wheezing and any asthma and allergy symptoms and diagnoses in the children were recorded, along with details of environmental exposures and family lifestyles. Between ages 7 and 8 the children had allergy skin and blood tests and lung function tests. Both mothers and children had genetic testing performed.

Professor Shaheen and researchers found evidence suggesting that the risk of childhood asthma associated with prenatal acetaminophen exposure depended on which variants of various antioxidant genes were present in the mother. In contrast, interactions between infant acetaminophen use and similar gene variants in the child were not seen. Shaheen added; "Our latest findings add further weight to the evidence implicating prenatal acetaminophen exposure in the development of childhood asthma. However, ultimately a cause and effect relationship can only be confirmed through randomised clinical trials."


Story Source:

The above story is based on materials provided by Queen Mary, University of London. Note: Materials may be edited for content and length.


Journal Reference:

  1. Seif O. Shaheen, Roger B. Newson, Susan M. Ring, Matthew J. Rose-Zerilli, John W. Holloway, A. John Henderson. Prenatal and infant acetaminophen exposure, antioxidant gene polymorphisms, and childhood asthma. Journal of Allergy and Clinical Immunology, 2010; DOI: 10.1016/j.jaci.2010.08.047

Cite This Page:

Queen Mary, University of London. "Evidence of link between acetaminophen use in pregnancy and childhood asthma, researchers say." ScienceDaily. ScienceDaily, 11 November 2010. <www.sciencedaily.com/releases/2010/11/101110101317.htm>.
Queen Mary, University of London. (2010, November 11). Evidence of link between acetaminophen use in pregnancy and childhood asthma, researchers say. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2010/11/101110101317.htm
Queen Mary, University of London. "Evidence of link between acetaminophen use in pregnancy and childhood asthma, researchers say." ScienceDaily. www.sciencedaily.com/releases/2010/11/101110101317.htm (accessed October 30, 2014).

Share This



More Health & Medicine News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Fauci Says Ebola Risk in US "essentially Zero"

Fauci Says Ebola Risk in US "essentially Zero"

AP (Oct. 30, 2014) NIAID Director Anthony Fauci said the risk of Ebola becoming an epidemic in the U.S. is essentially zero Thursday at the Washington Ideas Forum. He also said an Ebola vaccine will be tested in West Africa in the next few months. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Nurse Defies Ebola Quarantine With Bike Ride

Nurse Defies Ebola Quarantine With Bike Ride

AP (Oct. 30, 2014) A nurse who vowed to defy Maine's voluntary quarantine for health care workers who treated Ebola patients followed through on her promise Thursday, leaving her home for an hour-long bike ride. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Microsoft Launches Fitness Band After Accidental Reveal

Microsoft Launches Fitness Band After Accidental Reveal

Newsy (Oct. 30, 2014) Microsoft accidentally revealed its upcoming fitness band on Wednesday, so the company went ahead and announced it. Video provided by Newsy
Powered by NewsLook.com
Bracing to Meet a Killer: Aid Workers Prep for Ebola in Geneva

Bracing to Meet a Killer: Aid Workers Prep for Ebola in Geneva

AFP (Oct. 30, 2014) At the International Federation of Red Cross and Red Crescent Societies, around 30 doctors, nurses, lab technicians and water and sanitation workers are gathered for a crash-course in how to safely deal Ebola. Duration: 01:31 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins