Featured Research

from universities, journals, and other organizations

New urine test could diagnose acute kidney injury

Date:
November 11, 2010
Source:
American Society of Nephrology
Summary:
The presence of certain markers in the urine might be a red flag for acute kidney injury, according to a study appearing in an upcoming issue of the Journal of the American Society Nephrology. The results suggest that a simple urine test could help prevent cases of kidney failure.

The presence of certain markers in the urine might be a red flag for acute kidney injury (AKI), according to a study appearing in an upcoming issue of the Journal of the American Society Nephrology (JASN). The results suggest that a simple urine test could help prevent cases of kidney failure.

Related Articles


Unlike heart or brain injuries, which show obvious outward signs, physical symptoms are not typically present with AKI. Researchers have been looking for markers of AKI, with the hope that early detection will lead to early therapy to prevent kidney failure. Richard Zager, MD (Clinical Research Division, Fred Hutchinson Cancer Research Center) and his colleagues investigated whether certain molecules that are produced during injury and infection might be excreted in the urine and serve as diagnostic markers. Specifically, they measured the diagnostic potential of monocyte chemoattractant protein-1, a protein that plays a role in recruiting immune cells to injured or infected sites in the body. This protein has been found in the joints of people with rheumatoid arthritis and in the urine of people with lupus.

The investigators found elevated levels of monocyte chemoattractant protein-1 as well as its mRNA (the template for protein synthesis) in urine samples from both mice and human patients with AKI. This suggests that the gene that encodes this mRNA and protein is activated in patients with AKI. Using a new technique, known as chromatin immunoprecipitation assay, the investigators were also able to show changes in proteins (known as histones) that can activate the gene that produces MCP-1. This is the first time that the ability to detect these protein modifiers have been identified in human urine samples.

"This is a new diagnostic test that provides information about what processes are actually inducing acute kidney injury; however, a much larger prospective study is required to ultimately determine clinical utility," said Dr. Zager.

Study co-authors include Raj Munshi, MD (Seattle Children's Hospital and Regional Medical Center); Ali Johnson, PhD (Fred Hutchinson Cancer Research Center); Edward Siew, MD, T. Alp Ikizler, MD, Lorraine Ware, MD (Vanderbilt University Medical Center); and Mark Wurfel, MD, and Jonathan Himmelfarb, MD (University of Washington).


Story Source:

The above story is based on materials provided by American Society of Nephrology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Richard Zager et al. DMCP-1 Gene Activation Marks Acute Kidney Injury. Journal of the American Society Nephrology (JASN), November 11 2010 DOI: 10.1681/ASN.2010060641

Cite This Page:

American Society of Nephrology. "New urine test could diagnose acute kidney injury." ScienceDaily. ScienceDaily, 11 November 2010. <www.sciencedaily.com/releases/2010/11/101111172614.htm>.
American Society of Nephrology. (2010, November 11). New urine test could diagnose acute kidney injury. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2010/11/101111172614.htm
American Society of Nephrology. "New urine test could diagnose acute kidney injury." ScienceDaily. www.sciencedaily.com/releases/2010/11/101111172614.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Christmas Kissing Good for Health

Christmas Kissing Good for Health

Reuters - Innovations Video Online (Dec. 22, 2014) Scientists in Amsterdam say couples transfer tens of millions of microbes when they kiss, encouraging healthy exposure to bacteria. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Brain-Dwelling Tapeworm Reveals Genetic Secrets

Brain-Dwelling Tapeworm Reveals Genetic Secrets

Reuters - Innovations Video Online (Dec. 22, 2014) Cambridge scientists have unravelled the genetic code of a rare tapeworm that lived inside a patient's brain for at least four year. Researchers hope it will present new opportunities to diagnose and treat this invasive parasite. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins