Featured Research

from universities, journals, and other organizations

Depression-like behavior identified in zebrafish; Inability to cope with stress may play role in depression

Date:
November 18, 2010
Source:
Society for Neuroscience
Summary:
Disrupting the stress response in zebrafish generates behaviors that resemble depression, according to new research. Zebrafish are popular model systems in many areas of biomedical research, but this is the first discovery of a zebrafish mutant with an apparent psychiatric disorder.

Disrupting the stress response in zebrafish generates behaviors that resemble depression, according to new research presented at Neuroscience 2010, the annual meeting of the Society for Neuroscience, held in San Diego.

"Our findings offer a molecular basis for the intuition that long-term emotional well-being depends on an individual's ability to cope with stress," said Herwig Baier, PhD, of the University of California, San Francisco, who led the study.

Zebrafish are popular model systems in many areas of biomedical research, but this is the first discovery of a zebrafish mutant with an apparent psychiatric disorder. When faced repeatedly with a stressful situation -- isolation from others -- the mutant fish stop swimming and hide in the corner of the tank for many minutes. This abnormal behavior was reversed by bathing the fish in water containing fluoxetine (Prozac), a selective serotonin reuptake inhibitor (SSRI) commonly prescribed for people with depression.

Baier and his colleagues found that the "depressed" zebrafish had a genetic mutation in the glucocorticoid receptor (GR) gene. One of the functions of GR is to "dial down" the secretion of stress hormones from the brain. Both too much and too little GR activity has been implicated in depression. The zebrafish mutant had little to no GR activity.

"We do not know yet if all this also holds true for people. But if it does, then strategies aimed at finding new antidepressant therapies should try to resurrect, rather than block, GR activity," Baier said.

Research was supported by the National Institutes of Health.


Story Source:

The above story is based on materials provided by Society for Neuroscience. Note: Materials may be edited for content and length.


Cite This Page:

Society for Neuroscience. "Depression-like behavior identified in zebrafish; Inability to cope with stress may play role in depression." ScienceDaily. ScienceDaily, 18 November 2010. <www.sciencedaily.com/releases/2010/11/101116101736.htm>.
Society for Neuroscience. (2010, November 18). Depression-like behavior identified in zebrafish; Inability to cope with stress may play role in depression. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2010/11/101116101736.htm
Society for Neuroscience. "Depression-like behavior identified in zebrafish; Inability to cope with stress may play role in depression." ScienceDaily. www.sciencedaily.com/releases/2010/11/101116101736.htm (accessed April 23, 2014).

Share This



More Mind & Brain News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com
Do We Get Nicer With Age?

Do We Get Nicer With Age?

Newsy (Apr. 22, 2014) A recent report claims personality can change over time as we age, and usually that means becoming nicer and more emotionally stable. Video provided by Newsy
Powered by NewsLook.com
How to Master Motherhood With the Best Work/Life Balance

How to Master Motherhood With the Best Work/Life Balance

TheStreet (Apr. 22, 2014) In the U.S., there are more than 11 million couples trying to conceive at any given time. From helping celebrity moms like Bethanny Frankel to ordinary soon-to-be-moms, TV personality and parenting expert, Rosie Pope, gives you the inside scoop on mastering motherhood. London-born entrepreneur Pope is the creative force behind Rosie Pope Maternity and MomPrep. She explains why being an entrepreneur offers the best life balance for her and tips for all types of moms. Video provided by TheStreet
Powered by NewsLook.com
Sorry, Guys, Only Women Can Make Their Voices Sound Sexier

Sorry, Guys, Only Women Can Make Their Voices Sound Sexier

Newsy (Apr. 21, 2014) According to researchers at Albright College, women have the ability to make their voices sound sexier, but men don't. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins