Featured Research

from universities, journals, and other organizations

Immune system involved in depression, animal study suggests

Date:
November 17, 2010
Source:
Society for Neuroscience
Summary:
A new animal study suggests the immune system plays a role in depression. Activation of the immune system caused mice to learn to run less on wheels in their cages -- an activity they normally like. The mice resumed their normal activity when the action of interleukin-6, an immune hormone that carries "sickness" signals to the brain, was blocked.

A new animal study suggests the immune system plays a role in depression.

The research was presented at Neuroscience 2010, the annual meeting of the Society for Neuroscience, held in San Diego.

Activation of the immune system caused mice to learn to run less on wheels in their cages -- an activity they normally like. The mice resumed their normal activity when the action of interleukin-6, an immune hormone that carries "sickness" signals to the brain, was blocked.

"Our findings suggest that blocking the action of interleukin-6 might reduce depression symptoms, like fatigue or loss of interest in pleasurable activities, in people who are depressed and who have elevated levels of interleukin-6," said Simon Sydserff, PhD, a senior research scientist at BrainCells Inc., who conducted the research while with AstraZeneca Pharmaceuticals.

Scientists previously observed that some people became depressed due to an immune response to illness or stress. Elevated levels of immune hormones like interleukin-6 have been found in some depressed patients who are otherwise healthy. In addition, people who have never had a mental illness, but who are treated for other illnesses with immune- stimulating cytokines, often become depressed.

"These observations support the idea that depression may be caused in part by a breakdown in the normal communication between the immune system and the brain, causing people to experience the feelings associated with sickness even when they are medically healthy," Sydserff said.

Research was supported by AstraZeneca Pharmaceuticals.


Story Source:

The above story is based on materials provided by Society for Neuroscience. Note: Materials may be edited for content and length.


Cite This Page:

Society for Neuroscience. "Immune system involved in depression, animal study suggests." ScienceDaily. ScienceDaily, 17 November 2010. <www.sciencedaily.com/releases/2010/11/101116101836.htm>.
Society for Neuroscience. (2010, November 17). Immune system involved in depression, animal study suggests. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/2010/11/101116101836.htm
Society for Neuroscience. "Immune system involved in depression, animal study suggests." ScienceDaily. www.sciencedaily.com/releases/2010/11/101116101836.htm (accessed October 2, 2014).

Share This



More Health & Medicine News

Thursday, October 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Might Not Be Out Of Control In U.S., But Coverage Is

Ebola Might Not Be Out Of Control In U.S., But Coverage Is

Newsy (Oct. 2, 2014) Coverage of the lone Ebola patient discovered in Texas has U.S. media in a frenzy — but does the coverage match the reality? Video provided by Newsy
Powered by NewsLook.com
US Hunts Contacts of Ebola Patient, Including Children

US Hunts Contacts of Ebola Patient, Including Children

AFP (Oct. 2, 2014) Health officials in Texas on Wednesday scoured the Dallas area for people, including schoolchildren, who came in contact with a Liberian man who was diagnosed with Ebola in the United States. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Study Says Losing Sense Of Smell Can Indicate Death

Study Says Losing Sense Of Smell Can Indicate Death

Newsy (Oct. 2, 2014) Researchers found elderly adults with a poor sense of smell are more likely to die within five years. Video provided by Newsy
Powered by NewsLook.com
Pregnancy Spacing Could Have Big Impact On Autism Risks

Pregnancy Spacing Could Have Big Impact On Autism Risks

Newsy (Oct. 1, 2014) A new study says children born less than one year and more than five years after a sibling can have an increased risk for autism. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins