Featured Research

from universities, journals, and other organizations

Immune system involved in depression, animal study suggests

Date:
November 17, 2010
Source:
Society for Neuroscience
Summary:
A new animal study suggests the immune system plays a role in depression. Activation of the immune system caused mice to learn to run less on wheels in their cages -- an activity they normally like. The mice resumed their normal activity when the action of interleukin-6, an immune hormone that carries "sickness" signals to the brain, was blocked.

A new animal study suggests the immune system plays a role in depression.

Related Articles


The research was presented at Neuroscience 2010, the annual meeting of the Society for Neuroscience, held in San Diego.

Activation of the immune system caused mice to learn to run less on wheels in their cages -- an activity they normally like. The mice resumed their normal activity when the action of interleukin-6, an immune hormone that carries "sickness" signals to the brain, was blocked.

"Our findings suggest that blocking the action of interleukin-6 might reduce depression symptoms, like fatigue or loss of interest in pleasurable activities, in people who are depressed and who have elevated levels of interleukin-6," said Simon Sydserff, PhD, a senior research scientist at BrainCells Inc., who conducted the research while with AstraZeneca Pharmaceuticals.

Scientists previously observed that some people became depressed due to an immune response to illness or stress. Elevated levels of immune hormones like interleukin-6 have been found in some depressed patients who are otherwise healthy. In addition, people who have never had a mental illness, but who are treated for other illnesses with immune- stimulating cytokines, often become depressed.

"These observations support the idea that depression may be caused in part by a breakdown in the normal communication between the immune system and the brain, causing people to experience the feelings associated with sickness even when they are medically healthy," Sydserff said.

Research was supported by AstraZeneca Pharmaceuticals.


Story Source:

The above story is based on materials provided by Society for Neuroscience. Note: Materials may be edited for content and length.


Cite This Page:

Society for Neuroscience. "Immune system involved in depression, animal study suggests." ScienceDaily. ScienceDaily, 17 November 2010. <www.sciencedaily.com/releases/2010/11/101116101836.htm>.
Society for Neuroscience. (2010, November 17). Immune system involved in depression, animal study suggests. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2010/11/101116101836.htm
Society for Neuroscience. "Immune system involved in depression, animal study suggests." ScienceDaily. www.sciencedaily.com/releases/2010/11/101116101836.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins