Featured Research

from universities, journals, and other organizations

Small clumps of tau protein disrupt memory; Animal study suggests possible target for Alzheimer’s disease therapies

Date:
November 17, 2010
Source:
Society for Neuroscience
Summary:
Too many small aggregates of a protein called tau in the brain can directly interfere with memory, according to new animal research.

Too many small aggregates of a protein called tau in the brain can directly interfere with memory, according to new animal research presented at Neuroscience 2010, the annual meeting of the Society for Neuroscience, held in San Diego.

"Our findings are important because they suggest that tau may be a good target for developing therapies against Alzheimer's and related diseases," said senior author Ottavio Arancio, PhD, of Columbia University.

Many neurodegenerative diseases are marked by an accumulation of protein aggregates in the brain, and Alzheimer's disease is no exception. The two most common aggregating proteins associated with Alzheimer's disease are amyloid- beta and tau, which form the neural plaques and tangles that are hallmarks of the disease. Recently, scientists have begun to focus on some of the smaller, still-soluble forms of these protein aggregates, called oligomers, which may be especially toxic to neurons.

Arancio and his colleagues found that tau oligomers impaired fearful memories in mice. Tau oligomers also disrupted synaptic plasticity -- cellular events important for memory formation.

"Our findings suggest that tau is critically involved in the development of Alzheimer's disease -- and that reducing the abnormal aggregation of the protein may prove to be an effective treatment approach," Arancio said.

Research was supported by the Alzheimer's Drug Discovery Foundation, the National Institutes of Health, and Oligomerix, Inc.


Story Source:

The above story is based on materials provided by Society for Neuroscience. Note: Materials may be edited for content and length.


Cite This Page:

Society for Neuroscience. "Small clumps of tau protein disrupt memory; Animal study suggests possible target for Alzheimer’s disease therapies." ScienceDaily. ScienceDaily, 17 November 2010. <www.sciencedaily.com/releases/2010/11/101116204837.htm>.
Society for Neuroscience. (2010, November 17). Small clumps of tau protein disrupt memory; Animal study suggests possible target for Alzheimer’s disease therapies. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2010/11/101116204837.htm
Society for Neuroscience. "Small clumps of tau protein disrupt memory; Animal study suggests possible target for Alzheimer’s disease therapies." ScienceDaily. www.sciencedaily.com/releases/2010/11/101116204837.htm (accessed July 28, 2014).

Share This




More Mind & Brain News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Losing Sleep Leaves You Vulnerable To 'False Memories'

Losing Sleep Leaves You Vulnerable To 'False Memories'

Newsy (July 27, 2014) A new study shows sleep deprivation can make it harder for people to remember specific details of an event. Video provided by Newsy
Powered by NewsLook.com
University Quiz Implies Atheists Are Smarter Than Christians

University Quiz Implies Atheists Are Smarter Than Christians

Newsy (July 25, 2014) An online quiz from a required course at Ohio State is making waves for suggesting atheists are inherently smarter than Christians. Video provided by Newsy
Powered by NewsLook.com
Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins