Featured Research

from universities, journals, and other organizations

Abnormal blood values indicate increased mortality in PEG-operations

Date:
November 19, 2010
Source:
Karolinska Institutet
Summary:
The combination of high CRP and low levels of the protein albumin in the blood, is associated with an increased risk of death after a PEG-operation; implantation of a nutritional catheter into the stomach through the abdominal wall. Of the PEG patients in the study that showed both current indicators, 20 percent died within 30 days.

The combination of high CRP and low levels of the protein albumin in the blood, is associated with an increased risk of death after a PEG-operation; implantation of a nutritional catheter into the stomach through the abdominal wall. This was shown in a new study from the Swedish medical university Karolinska Institutet, published in the scientific journal Gastrointestinal Endoscopy. Of the PEG patients in the study that showed both current indicators, 20 percent died within 30 days.

Percutaneous Endoscopic Gastrostomy (PEG) means that you are operating a silicone tube for gastric feeding directly through the abdominal wall into the stomach. The method is used primarily on patients who for a long time have been unable to swallow and eat in the usual way to get nutrients, for example cancer of the throat or oesophagus or after a stroke. In Sweden, there are several thousands of PEG operations per year. One problem with surgery is that the risk of infection and other complications are high, which at worst can lead to death.

Albumin is the most abundant protein in the blood and is especially important to keep the blood fluid in the blood vessels. It is also associated with malnutrition and inflammation. CRP is a part of the immune system, and increase significantly in the concentration of bacterial infections and other inflammatory conditions. The researchers behind the current study say that their results suggest that healthcare providers should consider waiting before adding PEG at low albumin levels combined with high CRP.

The study included 484 patients at the Karolinska University Hospital in Stockholm County during the years 2005 to 2009. It shows that of the 167 patients who had the combination of low albumin and high CRP more than 20 percent died (34 patients) within 30 days. The mortality rate for the patients who had no such risk indicators was less than 3 percent. This corresponds to an increased risk of more than seven times, after taking into account possible confounding factors such as age, sex and underlying diseases such as diabetes, cardiovascular diseases including stroke and neurological diseases. 58 of the patients who participated in the study died.

"It may be worth trying to treat high CRP and provide the patient with nutrition with alternative methods, and then come back for PEG insertion if the infection has subsided and the patient feels better, says John Blomberg, surgeon and one of the researchers behind the study."In addition, the treating physician should inform the patient, relatives and remittent about the risks of PEG insertion, especially when the markers for premature death are so strong."


Story Source:

The above story is based on materials provided by Karolinska Institutet. Note: Materials may be edited for content and length.


Cite This Page:

Karolinska Institutet. "Abnormal blood values indicate increased mortality in PEG-operations." ScienceDaily. ScienceDaily, 19 November 2010. <www.sciencedaily.com/releases/2010/11/101119083222.htm>.
Karolinska Institutet. (2010, November 19). Abnormal blood values indicate increased mortality in PEG-operations. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2010/11/101119083222.htm
Karolinska Institutet. "Abnormal blood values indicate increased mortality in PEG-operations." ScienceDaily. www.sciencedaily.com/releases/2010/11/101119083222.htm (accessed April 20, 2014).

Share This



More Health & Medicine News

Sunday, April 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins