Featured Research

from universities, journals, and other organizations

Prostate cancer clinical stage does not predict recurrence, study suggests

Date:
November 22, 2010
Source:
Wiley-Blackwell
Summary:
A new study challenges the current staging system that determines the extent or severity of prostate cancer that has not metastasized. The study found that there is no link between localized prostate cancer's clinical stage and a patient's risk of cancer recurrence after having his prostate removed.

A new study challenges the current staging system that determines the extent or severity of prostate cancer that has not metastasized. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the study found that there is no link between localized prostate cancer's clinical stage and a patient's risk of cancer recurrence after having his prostate removed.

One of the primary purposes of staging prostate cancers is to help physicians determine a patient's prognosis. For example, a more advanced clinical stage should indicate a higher risk of cancer recurrence after treatment. Surprisingly, however, researchers have found that clinical stage is of questionable utility for predicting disease recurrence after surgical removal of the prostate (radical prostatectomy) in patients with localized prostate cancer.

Adam Reese, MD, of the University of California, San Francisco, and his colleagues questioned whether staging errors are responsible for this discrepancy. In other words, do physicians often inaccurately stage prostate cancer cases, and if so, does this account for the inconsistent reliability of clinical staging for predicting prostate cancer outcomes?

The investigators found that clinical stage was assigned incorrectly in 35.4 percent of 3,875 men in a multi-institutional national disease registry. The majority of these staging errors occurred because physicians frequently disregarded the results of transrectal ultrasound tests and incorrectly incorporated biopsy results when assigning stage.

Even after correcting these staging errors, however, there was no association between clinical stage and prostate cancer recurrence after radical prostatectomy. "Our findings question the utility of our current staging system for localized prostate cancer," said Dr. Reese.


Story Source:

The above story is based on materials provided by Wiley-Blackwell. Note: Materials may be edited for content and length.


Journal Reference:

  1. Adam C. Reese, Natalia Sadetsky, Peter R. Carroll and Matthew R. Cooperberg. Inaccuracies in assignment of clinical stage for localized prostate cancer. Cancer, 22 Nov 2010 DOI: 10.1002/cncr.25596

Cite This Page:

Wiley-Blackwell. "Prostate cancer clinical stage does not predict recurrence, study suggests." ScienceDaily. ScienceDaily, 22 November 2010. <www.sciencedaily.com/releases/2010/11/101122092525.htm>.
Wiley-Blackwell. (2010, November 22). Prostate cancer clinical stage does not predict recurrence, study suggests. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2010/11/101122092525.htm
Wiley-Blackwell. "Prostate cancer clinical stage does not predict recurrence, study suggests." ScienceDaily. www.sciencedaily.com/releases/2010/11/101122092525.htm (accessed April 20, 2014).

Share This



More Health & Medicine News

Sunday, April 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins