Featured Research

from universities, journals, and other organizations

Method for manufacturing patient-specific human platelets

Date:
November 22, 2010
Source:
Rockefeller University Press
Summary:
Skin cells from humans can be revamped into pro-clotting cells called platelets, according to a new study. Patients with diseases causing thrombocytopenia -- platelet deficiency -- often require repeated transfusions with platelets obtained from healthy donors.

Skin cells from humans can be revamped into pro-clotting cells called platelets, according to a study published on November 22 in the Journal of Experimental Medicine. Patients with diseases causing thrombocytopenia -- platelet deficiency -- often require repeated transfusions with platelets obtained from healthy donors.

But donor platelet isolation is expensive and labor intensive, and donor platelets can be attacked by the patient's immune systems as "foreign." Therefore, Koji Eto and colleagues sought a method for generating custom-made platelets from patients' own cells.

The team first reprogrammed human skin cells to a more primitive, stem cell-like state; these cells were then cultured in a cocktail of platelet-promoting soluble factors. The resulting platelets circulated and accumulated in blood clots when injected into platelet-deficient mice, behaving just like normal platelets.

Although additional work is needed to ensure that the culture-derived platelets function like normal healthy platelets, these findings represent an important step toward making patient-specific platelets clinically available.


Story Source:

The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Takayama, N., et al. Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells. Journal of Experimental Medicine, November 22, 2010 DOI: 10.1084/jem.20100844

Cite This Page:

Rockefeller University Press. "Method for manufacturing patient-specific human platelets." ScienceDaily. ScienceDaily, 22 November 2010. <www.sciencedaily.com/releases/2010/11/101122121639.htm>.
Rockefeller University Press. (2010, November 22). Method for manufacturing patient-specific human platelets. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2010/11/101122121639.htm
Rockefeller University Press. "Method for manufacturing patient-specific human platelets." ScienceDaily. www.sciencedaily.com/releases/2010/11/101122121639.htm (accessed August 21, 2014).

Share This




More Health & Medicine News

Thursday, August 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Possible Ebola Patient in Isolation at California Hospital

Possible Ebola Patient in Isolation at California Hospital

Reuters - US Online Video (Aug. 20, 2014) — A patient who may have been exposed to the Ebola virus is in isolation at the Kaiser Permanente South Sacramento Medical Center. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Raw: World's Oldest Man Lives in Japan

Raw: World's Oldest Man Lives in Japan

AP (Aug. 20, 2014) — A 111-year-old Japanese was certified as the world's oldest man by Guinness World Records on Wednesday. Sakari Momoi, a native of Fukushima in northern Japan, was given a certificate at a hospital in Tokyo. (Aug. 20) Video provided by AP
Powered by NewsLook.com
Do More Wedding Guests Make A Happier Marriage?

Do More Wedding Guests Make A Happier Marriage?

Newsy (Aug. 20, 2014) — A new study found couples who had at least 150 guests at their weddings were more likely to report being happy in their marriages. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Freetown a City on Edge

Ebola-Hit Sierra Leone's Freetown a City on Edge

AFP (Aug. 19, 2014) — Residents of Sierra Leone's capital voice their fears as the Ebola virus sweeps through west Africa. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins