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Method for manufacturing patient-specific human platelets

Date:
November 22, 2010
Source:
Rockefeller University Press
Summary:
Skin cells from humans can be revamped into pro-clotting cells called platelets, according to a new study. Patients with diseases causing thrombocytopenia -- platelet deficiency -- often require repeated transfusions with platelets obtained from healthy donors.

Skin cells from humans can be revamped into pro-clotting cells called platelets, according to a study published on November 22 in the Journal of Experimental Medicine. Patients with diseases causing thrombocytopenia -- platelet deficiency -- often require repeated transfusions with platelets obtained from healthy donors.

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But donor platelet isolation is expensive and labor intensive, and donor platelets can be attacked by the patient's immune systems as "foreign." Therefore, Koji Eto and colleagues sought a method for generating custom-made platelets from patients' own cells.

The team first reprogrammed human skin cells to a more primitive, stem cell-like state; these cells were then cultured in a cocktail of platelet-promoting soluble factors. The resulting platelets circulated and accumulated in blood clots when injected into platelet-deficient mice, behaving just like normal platelets.

Although additional work is needed to ensure that the culture-derived platelets function like normal healthy platelets, these findings represent an important step toward making patient-specific platelets clinically available.


Story Source:

The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Takayama, N., et al. Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells. Journal of Experimental Medicine, November 22, 2010 DOI: 10.1084/jem.20100844

Cite This Page:

Rockefeller University Press. "Method for manufacturing patient-specific human platelets." ScienceDaily. ScienceDaily, 22 November 2010. <www.sciencedaily.com/releases/2010/11/101122121639.htm>.
Rockefeller University Press. (2010, November 22). Method for manufacturing patient-specific human platelets. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2010/11/101122121639.htm
Rockefeller University Press. "Method for manufacturing patient-specific human platelets." ScienceDaily. www.sciencedaily.com/releases/2010/11/101122121639.htm (accessed October 30, 2014).

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