Featured Research

from universities, journals, and other organizations

New tool detects Ebola, Marburg quickly, easily

Date:
November 26, 2010
Source:
Boston University College of Engineering
Summary:
Researchers have developed a simple diagnostic tool that can quickly identify dangerous viruses like Ebola and Marburg. The biosensor, which is the size of a quarter and can detect viruses in a blood sample, could be used in developing nations, airports and other places where natural or man-made outbreaks could erupt.

Assistant Professor Hatice Altug (ECE).
Credit: Image courtesy of Boston University College of Engineering

Boston University researchers have developed a simple diagnostic tool that can quickly identify dangerous viruses like Ebola and Marburg. The biosensor, which is the size of a quarter and can detect viruses in a blood sample, could be used in developing nations, airports and other places where natural or man-made outbreaks could erupt.

Related Articles


"By enabling ultra-portable and fast detection, our technology can directly impact the course of our reaction against bio-terrorism threats and dramatically improve our capability to confine viral outbreaks," said Assistant Professor Hatice Altug of the Boston University College of Engineering, who co-led the research team with Assistant Professor John Connor of the Boston University School of Medicine.

Traditional virus diagnostic tools are effective, but require significant infrastructure and sample preparation time. The new biosensor developed at Boston University directly detects live viruses from biological media with little to no sample preparation. The breakthrough is detailed in the Nov. 5 online edition of Nano Letters.

From bird flu to H1N1, outbreaks of fast-spreading viral diseases in recent years have sparked concern of pandemics similar to the 1918 Spanish Flu that caused more than 50 million deaths. A significant fraction of today's viral threats are viruses that use RNA to replicate. Individuals infected with these viruses often show symptoms that are not virus-specific, making them difficult to diagnose. Among them are hemorrhagic fever viruses, such as Ebola and Marburg, which could be used as bio-warfare agents. Critical to identifying and containing future epidemics of RNA-based viruses is the development of rapid, sensitive diagnostic techniques that healthcare providers can quickly deploy so that infected individuals can be quickly identified and treated.

Partly funded through the Boston University Photonics Center and the U.S. Army Research Laboratory, and working in collaboration with the U.S. Army Medical Research Institute for Infectious Diseases, the team has demonstrated reliable detection of hemorrhagic fever virus surrogates (i.e. for the Ebola virus) and pox viruses (such as monkeypox or smallpox) in ordinary biological laboratory settings.

"Our platform can be easily adapted for point-of-care diagnostics to detect a broad range of viral pathogens in resource-limited clinical settings at the far corners of the world, in defense and homeland security applications as well as in civilian settings such as airports," said Altug.

Connor noted an additional, significant advantage of the new technology. "It will be relatively easy to develop a diagnostic device that simultaneously tests for several different viruses," he observed. "This could be extremely helpful in providing the proper diagnosis."

The new biosensor is the first to detect intact viruses by exploiting plasmonic nanohole arrays, or arrays of apertures with diameters of about 200 to 350 nanometers on metallic films that transmit light more strongly at certain wavelengths. When a live virus in a sample solution, such as blood or serum, binds to the sensor surface, the refractive index in the close vicinity of the sensor changes, causing a detectable shift in the resonance frequency of the light transmitted through the nanoholes. The magnitude of that shift reveals the presence and concentration of the virus in the solution.

"Unlike PCR and ELISA approaches, our method does not require enzymatic amplification of a signal or fluorescent tagging of a product, so samples can be read immediately following pathogen binding," said Altug. Ahmet Yanik, Altug's research associate who conducted the experiments, added, "Our platform can detect not only the presence of the intact viruses in the analyzed samples, but also indicate the intensity of the infection process."

The researchers are now working on a highly portable version of their biosensor platform using microfluidic technology designed for use in the field with minimal training.


Story Source:

The above story is based on materials provided by Boston University College of Engineering. The original article was written by Mark Dwortzan. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ahmet A. Yanik, Min Huang, Osami Kamohara, Alp Artar, Thomas W. Geisbert, John H. Connor, Hatice Altug. An Optofluidic Nanoplasmonic Biosensor for Direct Detection of Live Viruses from Biological Media. Nano Letters, 2010; 101108150434096 DOI: 10.1021/nl103025u

Cite This Page:

Boston University College of Engineering. "New tool detects Ebola, Marburg quickly, easily." ScienceDaily. ScienceDaily, 26 November 2010. <www.sciencedaily.com/releases/2010/11/101122141042.htm>.
Boston University College of Engineering. (2010, November 26). New tool detects Ebola, Marburg quickly, easily. ScienceDaily. Retrieved March 5, 2015 from www.sciencedaily.com/releases/2010/11/101122141042.htm
Boston University College of Engineering. "New tool detects Ebola, Marburg quickly, easily." ScienceDaily. www.sciencedaily.com/releases/2010/11/101122141042.htm (accessed March 5, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Thursday, March 5, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Praying Mantis Looks Long Before It Leaps

Praying Mantis Looks Long Before It Leaps

Reuters - Innovations Video Online (Mar. 5, 2015) — Slowed-down footage of the leaps of praying mantises show the insect&apos;s extraordinary precision, say researchers. Video provided by Reuters
Powered by NewsLook.com
Octopus Grabs Camera and Turns It Around On Photographer

Octopus Grabs Camera and Turns It Around On Photographer

Buzz60 (Mar. 5, 2015) — A photographer got the shot of a lifetime, or rather an octopus did, when it grabbed the camera and turned it around to take an amazing picture of the photographer. Jen Markham (@jenmarkham) has the story. Video provided by Buzz60
Powered by NewsLook.com
Ringling Bros. Eliminating Elephant Acts

Ringling Bros. Eliminating Elephant Acts

AP (Mar. 5, 2015) — The Ringling Bros. and Barnum & Bailey Circus is ending its iconic elephant acts. The circus&apos; parent company, Feld Entertainment, told the AP exclusively that the acts will be phased out by 2018 over growing public concern about the animals. (March 5) Video provided by AP
Powered by NewsLook.com
Raw: Tourists Visit Rare Grey Whales in Mexico

Raw: Tourists Visit Rare Grey Whales in Mexico

AP (Mar. 4, 2015) — Once nearly extinct, grey whales now migrate in their thousands to Mexico&apos;s Vizcaino reserve in Baja California, in search of warmer waters to mate and give birth. Tourists flock to the reserve to see the whales, measuring up to 49 feet long. (March 4) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins