Featured Research

from universities, journals, and other organizations

Nanoparticle gives antimicrobial ability to fight Listeria longer

Date:
December 8, 2010
Source:
Purdue University
Summary:
Scientists have developed a nanoparticle that can hold and release an antimicrobial agent as needed for extending the shelf life of foods susceptible to Listeria monocytogenes.

A Purdue University research team developed a nanoparticle that can hold and release an antimicrobial agent as needed for extending the shelf life of foods susceptible to Listeria monocytogenes.

Related Articles


Yuan Yao, an assistant professor of food science, altered the surface of a carbohydrate found in sweet corn called phytoglycogen, which led to the creation of several forms of a nanoparticle that could attract and stabilize nisin, a food-based antimicrobial peptide. The nanoparticle can then preserve nisin for up to three weeks, combating Listeria, a potentially lethal foodborne pathogen found in meats, dairy and vegetables that is especially troublesome for pregnant women, infants, older people and others with weakened immune systems.

Controlling Listeria at deli counters, for example, is especially problematic because meat is continually being opened, cut and stored, giving Listeria many chances to contaminate the food. Nisin alone is only effective at inhibiting Listeria for a short period -- possibly only a few days -- in many foods.

"People have been using nisin for a number of years, but the problem has been that it is depleted quickly in a food system," said Arun Bhunia, a Purdue professor of food science who co-authored a paper with Yao on the findings in the early online version of the Journal of Controlled Release. "This nanoparticle is an improved way to deliver the antimicrobial properties of nisin for extended use."

Yao used two strategies to attract nisin to the phytoglycogen nanopoarticles. First, he was able to negatively charge the surface of the nanoparticle and use electrostatic activity to attract the positively charged nisin molecules. Second, he created a partially hydrophobic condition on the surface of the nanoparticle, causing it to interact with partially hydrophobic nisin molecules. When the particles are hydrophobic, or repel water, they become attracted to each other.

"Both strategies may work together to allow nanoparticles to attract and stabilize nisin," Yao said, "This could substantially reduce the depletion of nisin in various systems."

For practical use, Yao said a solution containing the nanoparticles and free nisin could be sprayed onto foods or included in packaging. The solution requires a balance of free nisin and nisin on the nanoparticles.

"When you reduce the amount of free nisin, it will trigger a release of more nisin from the nanoparticles to re-establish the equilibrium," Yao said. "There will be a substantial amount of nisin preserved to counteract the Listeria."

Using a model, Yao said a sufficient amount of nisin to combat Listeria could be preserved for up to 21 days.

Yao and his colleagues are working on using other food-based antimicrobial peptides and nano-constructs to combat Listeria other foodborne pathogens such as E. coli O157:H7 and salmonella. The U.S. Department of Agriculture and the National Science Foundation funded their research.


Story Source:

The above story is based on materials provided by Purdue University. The original article was written by Brian Wallheimer. Note: Materials may be edited for content and length.


Journal Reference:

  1. Lin Bi, Lei Yang, Ganesan Narsimhan, Arun K. Bhunia, Yuan Yao. Designing carbohydrate nanoparticles for prolonged efficacy of antimicrobial peptide. Journal of Controlled Release, 2010; DOI: 10.1016/j.jconrel.2010.11.024

Cite This Page:

Purdue University. "Nanoparticle gives antimicrobial ability to fight Listeria longer." ScienceDaily. ScienceDaily, 8 December 2010. <www.sciencedaily.com/releases/2010/12/101207131739.htm>.
Purdue University. (2010, December 8). Nanoparticle gives antimicrobial ability to fight Listeria longer. ScienceDaily. Retrieved March 2, 2015 from www.sciencedaily.com/releases/2010/12/101207131739.htm
Purdue University. "Nanoparticle gives antimicrobial ability to fight Listeria longer." ScienceDaily. www.sciencedaily.com/releases/2010/12/101207131739.htm (accessed March 2, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 2, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Treadmill Test Can Predict Chance Of Death Within A Decade

Treadmill Test Can Predict Chance Of Death Within A Decade

Newsy (Mar. 2, 2015) Johns Hopkins researchers analyzed 58,000 heart stress tests to come up with a formula that predicts a person&apos;s chances of dying in the next decade. Video provided by Newsy
Powered by NewsLook.com
Going Gluten-Free Could Get You A Tax Break

Going Gluten-Free Could Get You A Tax Break

Newsy (Mar. 2, 2015) If a doctor advises you to remove gluten from your diet, you could get a tax deduction on the amount you spend on gluten-free foods. Video provided by Newsy
Powered by NewsLook.com
GlaxoSmithKline and Novartis Try Swapping Success

GlaxoSmithKline and Novartis Try Swapping Success

Reuters - Business Video Online (Mar. 2, 2015) GlaxoSmithKline and Novartis have completed a series of asset swaps worth more than $20 billion. As Grace Pascoe reports they say the deal will reshape both drugmakers. Video provided by Reuters
Powered by NewsLook.com
How Can West Africa Rebuild After Ebola?

How Can West Africa Rebuild After Ebola?

Reuters - Business Video Online (Mar. 2, 2015) How best to rebuild the three West African countries struggling with Ebola will be discussed in Brussels this week. As Hayley Platt reports Sierra Leone has the toughest job ahead - its once thriving economy has been ravaged by the disease. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins