Featured Research

from universities, journals, and other organizations

People at highest risk of sudden unexpected death in epilepsy

Date:
December 7, 2010
Source:
American Epilepsy Society (AES)
Summary:
Sudden unexpected death in epilepsy is the most common condition-related cause of death in chronic epilepsy. New research shows significant risk factors for SUDEP including increased frequency of generalized tonic-clonic seizures, taking more than one anticonvulsant medication, long duration of epilepsy, young age at onset, gender, symptomatic cause, and lamotrigine therapy.

Sudden unexpected death in epilepsy (SUDEP) is the most common condition-related cause of death in chronic epilepsy. Case-control studies using living people with epilepsy as controls have aimed at identifying factors that distinguish the epilepsy patient at risk of SUDEP, but there are disagreements between studies and a lack of precision in the risk estimates attributed, in part, to the small number of cases in each study.

To counterbalance these study limitations, the Epidemiology Task Force of the International League Against Epilepsy (ILAE) pooled data from four published studies of SUDEP from the U.S., Sweden, Scotland and England.

SUDEP in the study was defined as 1) having a history of epilepsy (one or more seizures during a five-year period), 2) death occurring suddenly, 3) death unexpected with no life-threatening illness, 4) death remaining unexplained after all investigative efforts, including autopsy. (Platform C.03)

Analysis of the pooled data revealed statistically significant risk factors for SUDEP, including increased frequency of generalized tonic-clonic seizures (GTCS), taking more than one anticonvulsant medication (AED), long duration of epilepsy, young age at onset, gender, symptomatic cause, and lamotrigine therapy. The results persisted for both people younger than age 16 and for adults over the age of 16.

According to epidemiologist Dale C. Hesdorffer, Ph.D., of Columbia University, "The emerging profile from our pooled analysis indicates that people with early onset refractory symptomatic epilepsy who have frequent GTCS and take more than one AED are at highest risk. The results suggest that reducing the number of these generalized seizures is a priority of more importance than reducing the number of AEDs."

The researchers also say the role of AEDs and other forms of treatment should be analyzed further in future studies. A further challenge for future research is to focus on patients with refractory epilepsy to clarify what features may distinguish the patients in this high risk population that die in SUDEP from those who survive.


Story Source:

The above story is based on materials provided by American Epilepsy Society (AES). Note: Materials may be edited for content and length.


Cite This Page:

American Epilepsy Society (AES). "People at highest risk of sudden unexpected death in epilepsy." ScienceDaily. ScienceDaily, 7 December 2010. <www.sciencedaily.com/releases/2010/12/101207155139.htm>.
American Epilepsy Society (AES). (2010, December 7). People at highest risk of sudden unexpected death in epilepsy. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2010/12/101207155139.htm
American Epilepsy Society (AES). "People at highest risk of sudden unexpected death in epilepsy." ScienceDaily. www.sciencedaily.com/releases/2010/12/101207155139.htm (accessed September 17, 2014).

Share This



More Health & Medicine News

Wednesday, September 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Man Floats for 31 Hours in Gulf Waters

Man Floats for 31 Hours in Gulf Waters

AP (Sep. 16, 2014) A Texas man is lucky to be alive after he and three others floated for more than a day in the Gulf of Mexico when their boat sank during a fishing trip. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

AFP (Sep. 16, 2014) Since the arrival of Ebola in Ivory Coast, Ivorians have been abandoning their pets, particularly monkeys, in the fear that they may transmit the virus. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com
Study Links Male-Pattern Baldness To Prostate Cancer

Study Links Male-Pattern Baldness To Prostate Cancer

Newsy (Sep. 16, 2014) New findings suggest men with a certain type of baldness at age 45 are 39 percent more likely to develop aggressive prostate cancer. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

      Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins